News Muncher - searching for activation

13 hours, 52 minutes ago

Rural consumption outpaces urban: How FMCG giants are changing their strategies

New Delhi: Makers of fast-moving consumer goods are increasing the availability of products in smaller packs and introducing rural-specific brands following a sustained recovery in demand in these markets and wider acceptance of branded food and confectionery. Zydus Wellness, Godrej Consumer Products and Dabur have intensified their marketing in rural areas and have prioritised the supply of affordable hair colours, …

India Consumer Markets Urban Products Rural Areas Areas

1 day, 4 hours ago

EPFO extends deadline for UAN activation, linking bank account to Aadhaar for ELI scheme benefits to Jan 15

Live Mint

The Employees Provident Fund Organisation has extended the deadline for UAN activation and seeding of bank accounts to Aadhaar to avail the benefits under the ELI scheme to January 15. Seeding of bank account with Aadhaar A bank account needs to be linked to Aadhaar so that whenever money is disbursed by the EPFO, it is directly transferred to the …

Benefits Aadhaar Bank Scheme Account Epfo Eli

4 days, 20 hours ago

Paytm Money launches 'Pay Later' Margin Trading. 3 things to know

India Today

Wealth Tech app, Paytm Money, has launched the 'Pay Later' Margin Trading Facility, enabling investors to trade stocks with minimal upfront investment. This streamlined process empowers retail investors across India, making it easier to participate in the stock market without committing large sums of capital upfront. By democratising stock market participation, Paytm Money ensures greater financial accessibility for traders and …

Pay Stock Investors Paytm Money

1 week, 3 days ago

Why You Should Avoid Buying A Gift Card From The Display Rack At The Store

Huff Post

Illustration:Jianan Liu/HuffPost Photo:Getty Images The longer you wait to use a gift card, the more opportunities scammers have for gift card fraud. Here’s how the physical gift card scheme typically works: Scammers will target display racks of gift cards, especially when the rack is out of sight from cashiers or pharmacy counters, explained Kathy Stokes, director of fraud prevention programs …

Money Gift Scammers Card Cards Funds Stokes

1 week, 5 days ago

UEFA hits Serbia with partial stadium closures over supporter behaviour

The Hindu

Serbia has been hit with partial stadium closures for two home matches and banned from selling tickets to their fans in two away ties over supporter behaviour in last month’s Nations League games against Switzerland and Denmark, UEFA said. Serbian fans displayed “racist and discriminatory” behaviour, caused damage to the stadium, threw objects and lit fireworks during a 1-1 draw …

Denmark Serbia Uefa Hits

2 weeks, 1 day ago

Tom Cruise’s ex-wife Katie Holmes reacts to Suri’s ‘trust fund’ activation: ‘Enough’

Hindustan Times

Katie Holmes, the ex-wife of Top Gun star Tom Cruise, has addressed reports claiming their daughter, Suri, became an overnight millionaire after her father’s trust fund allegedly "kicked in" when she turned 18 and started college. Katie Holmes slams Suri ‘trust fund’ reports On Sunday, Dec. 8, Katie Holmes, 45, took to Instagram to dispute a report from the Daily …

Trust Fund Daughter Her Daughter Her Mother Tom Katie

2 weeks, 5 days ago

EPFO extends deadline for UAN activation and linking bank a/c to Aadhaar for ELI scheme benefits to Dec 15

Live Mint

EPFO has extended the deadline for UAN activation and seeding bank accounts with Aadhaar for availing the benefits under ELI scheme till Dec 15. In the latest circular dated December 4, Employees Provident Fund Organisation has issued directions to all employers that the earlier circular stands modified. Extension of timeline "The competent authority has granted an extension of timeline from …

Aadhaar Bank Bank Accounts Account Epfo Dec Eli

2 weeks, 5 days ago

Thryve Digital Health Honored with Dual Win at the Indian CSR Awards 2024

Live Mint

New Delhi: Thryve Digital Health, a leading provider of healthcare technology and operations services to some of the United States' foremost payors and providers, has received two prestigious honors at the Indian CSR Awards 2024, for the exceptional work in the field of Corporate Social Responsibility. It is a tribute to every Thryvian who strives to make the world a …

Health India Healthcare Indian Digital Brand Pti

IIM CAT 2024 answer keys: Last day to raise objections, details here

India Today

The Indian Institute of Management, Calcutta, will close the objection window for the IIM CAT 2024 today, December 5, 2024. The provisional answer key for CAT 2024 was released on December 3, 2024, along with the activation of the answer key objection window. CAT 2024: STEPS TO RAISE CHALLENGES To challenge the CAT 2024 answer key, follow these steps: 1. …

2024 Cat Answer Cat 2024 Official Website Key Objection

3 weeks ago

Hyderabad Man Loses over Rs 2 Lakh in Cyber Fraud

Deccan Chronicle

Hyderabad: A private employee, who wanted a personal loan from a leading financial institution, passed on sensitive information to a cyberfraudster and lost Rs 2,10,889 in the proces. The 51-year-old victim from Hyderabad had applied for a personal loan from a reputed financial institution. The scammer posing as representative of that company, told the victim that he was eligible for …

Hyderabad

3 weeks, 1 day ago

Breakthrough brain discovery may lead to ‘yoga pill’, scientists say

The Independent

Sign up for our free Health Check email to receive exclusive analysis on the week in health Get our free Health Check email Get our free Health Check email SIGN UP I would like to be emailed about offers, events and updates from The Independent. Read our privacy policy A breakthrough brain circuit discovery may lead to new treatments for …

Anxiety Health Check Breathing Slow Brainstem Emotional State Breakthrough Brain

3 weeks, 1 day ago

Switching jobs? You should not ignore this EPFO advice

India Today

If you're changing jobs, the Employees Provident Fund Organisation has an important guideline. A UAN is a 12-digit number that serves as a unique identifier for your EPF account, ensuring your provident fund remains linked to you across different employers. If you have been assigned multiple UANs, you should consolidate all your previous employment details into your current UAN using …

Aadhaar Number Epfo Details Otp Uan Your Uan

3 weeks, 4 days ago

Rejected credit card? Here’s what to do next: A step-by-step guide

Live Mint

Credit cards are one of the most preferred financial tools as they help customers make purchases without the need to pay back immediately, along with added rewards and offers. Applying for a credit card is very easy, however, issuers look for many criteria before approving a credit card application therefore many applications get rejected. Reasons for rejection of credit card …

Credit Credit Card Application Debt Report Card Score

3 weeks, 4 days ago

What amounts to the activation of credit card? An explainer

Live Mint

Using a credit card, as we know, offers a range of benefits and rewards such as access to lounges, discounts on shopping and travel and dining. Select your credit card and enable transaction rights Activate credit card through customer support 1. The RBI directions dated March 7, 2024 on the issuance of credit cards highlight that a card should not …

Credit Credit Card Customer Support Card Customer Your Credit Card Activate

1 month ago

Boost the TB fight with better undernutrition monitoring

The Hindu

Around one-third of tuberculosis in India is attributable to undernutrition, which, in adults, is defined as having a body mass index less than 18.5 kg/m². In India, available research suggests the burden of ‘severe’ and ‘very severe’ undernutrition to be very high among adults with TB. The Reducing Activation of Tuberculosis by Improvement of Nutritional Status trial from Jharkhand documented …

India Support Nutrition Care Adults Severe Bmi

Delhi wakes up to hazy morning as air quality remains 'very poor' with AQI at 373

India TV News

Delhiites woke up to a hazy morning on Wednesday, with the minimum temperature recorded at 11.3°C and the air quality continuing to remain in the "very poor" category. Of the 38 monitoring stations in the city, nine reported AQI levels in the "severe" range, including areas like Anand Vihar, Bawana, Jahangirpuri, Mundka, Nehru Nagar, Shadipur, Sonia Vihar, Vivek Vihar, and …

Delhi Quality Air Poor Severe Levels Aqi

1 month ago

Attention PAN cardholders: Here's how to check if your PAN card is active or not

India TV News

Attention PAN card holders. The Permanent Account Number card is a crucial document for financial transactions and if you have recently applied for a new PAN card or have an existing one, it is essential to know how to check if your PAN card is active or not. After it is activated, your PAN card becomes a valid identification for …

Card Check Pan Active Your Pan Card

1 month ago

Delhi smog: How do pilots deal with low visibility?

Hindustan Times

Delhi's AQI rose to a hazardous 481 on Monday, causing dense fog that prompted low- visibility procedures to be initiated by the Delhi International Airport Ltd, reported news agency PTI. Low visibility procedures have been initiated in Delhi airport In a post on X, DIAL said, “Low visibility procedures are in progress at Delhi airport. All flight operations are normal …

Delhi Airport Pti Low Visibility Low Visibility Low Visibility Procedures

1 month, 1 week ago

Fears of unrest surround Rotterdam defense expo amid heightened security

NL Times

Police in Rotterdam have activated a Large-Scale and Special Operations Command ahead of the international defense exhibition NEDS, scheduled to take place on November 21. Environmental protest planned, other groups may join An environmental group has announced plans to protest at the defense expo, and police are preparing for the possibility that other groups may join the demonstration. Police remain …

Rotterdam Sgbo

1 month, 1 week ago

Solo Leveling, One Piece, Blue Lock anime fans will be pleased with Crunchyroll's Hyderabad Comic Con booth this weekend

Hindustan Times

Crunchyroll is curating an immersive and unforgettable anime experience for anime superfans heading to the Hyderabad Comic Con 2025 in India this weekend. What can anime fans look forward to at the Crunchyroll booth at Hyderabad Comic Con? The Hyderabad Crunchyroll booth will celebrate Eiichiro Oda’s iconic manga series One Piece’s 25th anniversary, allowing fans to set sail on epic …

India Anime Hyderabad Fans Piece Booth Comic

1 month, 1 week ago

Chandigarh gets cracking as AQI stays in very poor range

Hindustan Times

With Chandigarh’s Air Quality Index remaining in the very poor category for the sixth consecutive day, the UT administration has swung into action to address the ongoing air crisis. As of 8 pm on Monday, the AQI was 335 at the Continuous Ambient Air Quality Monitoring Station in Sector 22, 317 in Sector 25 and 341 in Sector 53, all …

Traffic Quality Air Poor Chandigarh Sector Pec

中国科学家发现植物免疫激活新机制

China Daily

中国日报11月8日电（记者闫东洁）近年来，病虫害的频繁爆发造成作物减产和品质下降, 大量使用化学农药控制农作物病虫害，不仅破坏生态环境，还威胁人们健康。培育广谱抗病品种是保障我国粮食安全、发展绿色农业、维护生态环境的重要举措。发掘广谱持久抗病基因，揭示植物免疫激活调控广谱抗病的分子机制是农作物抗病育种的重要理论基础。北京时间2024年11月8日，国际权威学术期刊《科学》（Science）以"背靠背"形式在线发布了同一单位不同团队的两项重要科研成果。中国科学院分子植物科学卓越创新中心何祖华院士团队、张余研究员团队，复旦大学高明君研究员团队以及浙江大学邓一文教授团队合作完成了题为 "A canonical protein complex controls immune homeostasis and multipathogen resistance（一个经典的蛋白复合体调控免疫稳态与多病原菌抗性）"的研究成果。另一篇题为"Activation of a helper NLR by plant and bacterial TIR immune signaling（植物和细菌的免疫信号介导植物细胞内免疫受体的激活）"的研究成果来自分子植物卓越中心万里研究员团队。植物免疫的本质是识别"非我"。植物免疫系统通过识别病原微生物而激活自身的免疫反应，该系统由两道防线组成，一是通过植物细胞表面感受器识别病原菌后产生的基础抗病性（PTI），PTI相对温和且容易被病原菌分泌的毒性蛋白所突破；在进化中，植物产生了第二道防线，植物细胞内感受器NLR蛋白识别病原菌分泌的毒性蛋白后引起的专化性抗性（ETI），该防线反应强烈且能赋予植物强抗病性。植物ETI免疫反应的发生依赖于植物特定的NLR感受器蛋白识别特定病原菌分泌的特定毒性蛋白。由于ETI的特异性，目前在植物抗病育种和病虫害防治中缺乏有效的方法激活植物ETI。如何克服ETI对病原菌的特异性，实现有效的多病原广谱抗病性成为了植物免疫研究的重要课题。何祖华及其合作研究团队在前期研究中发现了一个水稻免疫抑制基因ROD1，该基因突变引起活性氧积累，产生免疫自激活表型，显著提高水稻对多个病原菌如稻瘟病、白叶枯病和纹枯病的抗性，论文发表于国际权威学术期刊Cell（Gao et al., 2021）。然而对ROD1抑制免疫激活的信号网络尚不清楚。研究团队采用EMS化学诱变和γ射线物理诱变筛选rod1抑制子的策略深入研究，经过大规模的田间表型鉴定筛选，共获得18个rod1抑制子株系。通过基因克隆和全基因组测序分析，发现这些抑制子分别是OsTIR、OsEDS1、OsPAD4和OsADR1基因突变。首次报道禾本科作物的细胞内感受器OsTIR蛋白具有产生免疫小分子pRib-AMP的功能，小分子pRib-AMP能够激活水稻OsEDS1、OsPAD4和OsADR1蛋白形成免疫复合体EPA激发免疫反应。进一步研究发现水稻免疫抑制蛋白ROD1与OsTIR互作，影响OsTIR的酶活，从而抑制小分子pRib-AMP的生成，避免EPA复合体激发免疫反应，维持免疫的稳态。当病原菌侵染时，ROD1被降解，OsTIR蛋白被释放后生成小分子激活免疫复合体EPA，产生对多种病原菌的广谱抗性。因此，该研究揭示了一个五组分的信号网络调控植物免疫稳态的分子机制，为培育广谱抗多种病原菌的作物新品种提供重要的理论基础和靶标基因。无独有偶的是万里团队发现植物细胞内感受器的TIR蛋白可生成小分子2'cADPR，这一类小分子作为前体在植物体内可以被转化生成pRib-AMP，从而激活EPA免疫复合体，提高植物抗病性。利用2'cADPR处理植物即可诱导类似于ETI的强抗病性，实现了在没有特定病原菌侵染的情况下人为可控地激活植物强ETI免疫反应。而且相对于pRib-AMP，2'cADPR性质更稳定，所以也更适合开发作为植物免疫激活剂。这一发现为发展绿色农业提供了一种能够激发农作物广谱抗病性的新型"生物农药"，从而有效替代化学农药，减少对生态环境的负面影响。一些细菌的TIR蛋白也可以产生2'cADPR并激活植物的ETI免疫反应，因此本研究还揭示了植物和细菌免疫通路交互的分子机理。植物细胞内感受器TIR蛋白介导的ETI抗性是农作物抗病育种的重要靶标。因此，研究植物免疫受体及其工作机理，能够实现对植物免疫受体的人工定向改造，从而有效解决植物病害问题。这两项研究成果共同揭示了一个在不同植物中保守的由小分子pRib-AMP和蛋白复合体EPA介导的免疫激活新机制，为植物病害防控提供了新型"生物农药"靶标，对促进我国农业绿色可持续发展，维护生态环境，保障粮食安全具有重要意义。分子植物卓越中心博士研究生武越、徐炜莹、雷子耀，高级工程师刘继云，上海科技大学博士研究生赵国燕以及复旦大学博士研究生李魁为论文"A canonical protein complex controls immune homeostasis and multipathogen resistance"的共同第一作者，分子植物卓越中心何祖华院士、张余研究员，复旦大学高明君研究员以及浙江大学邓一文教授为共同通讯作者。德国马普植物育种研究所Jane E. Parker院士、西湖大学柴继杰教授等参与了本项研究。该研究工作受到国家自然科学基金、农业生物育种重大专项、国家重点研发计划、上海市基础研究特区计划等的资助。分子植物卓越中心博士研究生于华、徐炜莹和陈思思为论文"Activation of a helper NLR by plant and bacterial TIR immune signaling"的共同第一作者，万里研究员为通讯作者。该研究工作得到了中国科学院分子植物科学卓越创新中心张余研究员的合作和支持。同时，该研究工作得到国家重点研发计划、植物性状形成与塑造重点实验室（中国科学院）、国家自然科学基金面上项目和中国科学院先导项目等资助。【责任编辑：高琳琳】

Tir Controls Immune

中国科学家发现植物免疫激活新机制

China Daily

中国日报11月8日电（记者闫东洁）近年来，病虫害的频繁爆发造成作物减产和品质下降, 大量使用化学农药控制农作物病虫害，不仅破坏生态环境，还威胁人们健康。培育广谱抗病品种是保障我国粮食安全、发展绿色农业、维护生态环境的重要举措。发掘广谱持久抗病基因，揭示植物免疫激活调控广谱抗病的分子机制是农作物抗病育种的重要理论基础。北京时间2024年11月8日，国际权威学术期刊《科学》（Science）以"背靠背"形式在线发布了同一单位不同团队的两项重要科研成果。中国科学院分子植物科学卓越创新中心何祖华院士团队、张余研究员团队，复旦大学高明君研究员团队以及浙江大学邓一文教授团队合作完成了题为 "A canonical protein complex controls immune homeostasis and multipathogen resistance（一个经典的蛋白复合体调控免疫稳态与多病原菌抗性）"的研究成果。另一篇题为"Activation of a helper NLR by plant and bacterial TIR immune signaling（植物和细菌的免疫信号介导植物细胞内免疫受体的激活）"的研究成果来自分子植物卓越中心万里研究员团队。植物免疫的本质是识别"非我"。植物免疫系统通过识别病原微生物而激活自身的免疫反应，该系统由两道防线组成，一是通过植物细胞表面感受器识别病原菌后产生的基础抗病性（PTI），PTI相对温和且容易被病原菌分泌的毒性蛋白所突破；在进化中，植物产生了第二道防线，植物细胞内感受器NLR蛋白识别病原菌分泌的毒性蛋白后引起的专化性抗性（ETI），该防线反应强烈且能赋予植物强抗病性。植物ETI免疫反应的发生依赖于植物特定的NLR感受器蛋白识别特定病原菌分泌的特定毒性蛋白。由于ETI的特异性，目前在植物抗病育种和病虫害防治中缺乏有效的方法激活植物ETI。如何克服ETI对病原菌的特异性，实现有效的多病原广谱抗病性成为了植物免疫研究的重要课题。何祖华及其合作研究团队在前期研究中发现了一个水稻免疫抑制基因ROD1，该基因突变引起活性氧积累，产生免疫自激活表型，显著提高水稻对多个病原菌如稻瘟病、白叶枯病和纹枯病的抗性，论文发表于国际权威学术期刊Cell（Gao et al., 2021）。然而对ROD1抑制免疫激活的信号网络尚不清楚。研究团队采用EMS化学诱变和γ射线物理诱变筛选rod1抑制子的策略深入研究，经过大规模的田间表型鉴定筛选，共获得18个rod1抑制子株系。通过基因克隆和全基因组测序分析，发现这些抑制子分别是OsTIR、OsEDS1、OsPAD4和OsADR1基因突变。首次报道禾本科作物的细胞内感受器OsTIR蛋白具有产生免疫小分子pRib-AMP的功能，小分子pRib-AMP能够激活水稻OsEDS1、OsPAD4和OsADR1蛋白形成免疫复合体EPA激发免疫反应。进一步研究发现水稻免疫抑制蛋白ROD1与OsTIR互作，影响OsTIR的酶活，从而抑制小分子pRib-AMP的生成，避免EPA复合体激发免疫反应，维持免疫的稳态。当病原菌侵染时，ROD1被降解，OsTIR蛋白被释放后生成小分子激活免疫复合体EPA，产生对多种病原菌的广谱抗性。因此，该研究揭示了一个五组分的信号网络调控植物免疫稳态的分子机制，为培育广谱抗多种病原菌的作物新品种提供重要的理论基础和靶标基因。无独有偶的是万里团队发现植物细胞内感受器的TIR蛋白可生成小分子2'cADPR，这一类小分子作为前体在植物体内可以被转化生成pRib-AMP，从而激活EPA免疫复合体，提高植物抗病性。利用2'cADPR处理植物即可诱导类似于ETI的强抗病性，实现了在没有特定病原菌侵染的情况下人为可控地激活植物强ETI免疫反应。而且相对于pRib-AMP，2'cADPR性质更稳定，所以也更适合开发作为植物免疫激活剂。这一发现为发展绿色农业提供了一种能够激发农作物广谱抗病性的新型"生物农药"，从而有效替代化学农药，减少对生态环境的负面影响。一些细菌的TIR蛋白也可以产生2'cADPR并激活植物的ETI免疫反应，因此本研究还揭示了植物和细菌免疫通路交互的分子机理。植物细胞内感受器TIR蛋白介导的ETI抗性是农作物抗病育种的重要靶标。因此，研究植物免疫受体及其工作机理，能够实现对植物免疫受体的人工定向改造，从而有效解决植物病害问题。这两项研究成果共同揭示了一个在不同植物中保守的由小分子pRib-AMP和蛋白复合体EPA介导的免疫激活新机制，为植物病害防控提供了新型"生物农药"靶标，对促进我国农业绿色可持续发展，维护生态环境，保障粮食安全具有重要意义。分子植物卓越中心博士研究生武越、徐炜莹、雷子耀，高级工程师刘继云，上海科技大学博士研究生赵国燕以及复旦大学博士研究生李魁为论文"A canonical protein complex controls immune homeostasis and multipathogen resistance"的共同第一作者，分子植物卓越中心何祖华院士、张余研究员，复旦大学高明君研究员以及浙江大学邓一文教授为共同通讯作者。德国马普植物育种研究所Jane E. Parker院士、西湖大学柴继杰教授等参与了本项研究。该研究工作受到国家自然科学基金、农业生物育种重大专项、国家重点研发计划、上海市基础研究特区计划等的资助。分子植物卓越中心博士研究生于华、徐炜莹和陈思思为论文"Activation of a helper NLR by plant and bacterial TIR immune signaling"的共同第一作者，万里研究员为通讯作者。该研究工作得到了中国科学院分子植物科学卓越创新中心张余研究员的合作和支持。同时，该研究工作得到国家重点研发计划、植物性状形成与塑造重点实验室（中国科学院）、国家自然科学基金面上项目和中国科学院先导项目等资助。【责任编辑：高琳琳】

Tir Immune Homeostasis Protein Complex

1 month, 4 weeks ago

Scientists Discover Mechanism of Allergic Disease Activation Through Protein Shape Shift

China Daily

Chinese researchers have discovered that morphological changes of an immune receptor play a key role in allergic reactions. The study analyzed protein structures and found that when the antibody binds to the immune receptor, the shape of the receptor changes, exposing specific protein sites in the associated signaling pathways, which in turn activates these pathways and triggers allergic responses.

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中国科学家发现植物免疫激活新机制

中国科学家发现植物免疫激活新机制

Scientists Discover Mechanism of Allergic Disease Activation Through Protein Shape Shift