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Search results for brenner

The Latest: The famed Notre Dame Cathedral in Paris reopens to great fanfare
2 weeks, 3 days ago

The Latest: The famed Notre Dame Cathedral in Paris reopens to great fanfare

Associated Press  

PARIS — Notre Dame is reopening its doors for the first time since a fire in 2019 nearly destroyed Paris’ beloved 12th-century cathedral. For more of AP’s coverage on Notre Dame, visit https://apnews.com/hub/notre-dame-cathedral ___ Here’s the latest: Macron welcomes Trump to Paris with presidential pomp, includes him in talks with Zelenskyy French President Emmanuel Macron welcomed Donald Trump to Paris …

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Teyonah Parris joins John Cena in ‘Matchbox’
2 weeks, 3 days ago

Teyonah Parris joins John Cena in ‘Matchbox’

The Hindu  

The Marvels star Teyonah Parris will appear alongside John Cena in Matchbox, a live-action film based on the iconic Mattel car toyline. Sam Hargrave, known for directing Chris Hemsworth-led Extraction movies, will helm the project from a screenplay by David Coggeshall and Jonathan Tropper. David Ellison, Dana Goldberg and Don Granger will produce the movie for Skydance, alongside Robbie Brenner …

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‘Waiting for Godot’s’ opening-night bash at Geffen Playhouse: L.A. arts and culture this week
1 month, 1 week ago

‘Waiting for Godot’s’ opening-night bash at Geffen Playhouse: L.A. arts and culture this week

LA Times  

The crowd was jubilant on the opening night of “Waiting for Godot” at the Geffen Playhouse last Thursday. Best bets: On our radar this week Faniswa Yisa, left, Billy Edward, Craig Leo, Carlo Daniels, Sandra Pinsloo and Andrew Buckland in “Life & Times of Michael K.” ‘Life & Times of Michael K’ Times theater critic Charles McNulty has been eyeing …

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Eddie Redmayne says he’s ‘learned his lesson’ after backlash for problematic role
1 month, 1 week ago

Eddie Redmayne says he’s ‘learned his lesson’ after backlash for problematic role

The Independent  

For free real time breaking news alerts sent straight to your inbox sign up to our breaking news emails Sign up to our free breaking news emails Sign up to our free breaking news emails SIGN UP I would like to be emailed about offers, events and updates from The Independent. The 42-year-old was nominated for an Oscar for his …

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Directors remake ‘Sunset Blvd.,’ ‘Romeo + Juliet’ and ‘Our Town’ for a new Broadway era
1 month, 1 week ago

Directors remake ‘Sunset Blvd.,’ ‘Romeo + Juliet’ and ‘Our Town’ for a new Broadway era

LA Times  

Three shows well known to theater audiences have undergone radical Broadway makeovers this fall at the hands of directors who recognize that plays and musicals must be in dialogue with their times. Lloyd has brought his sensational production of “Sunset Blvd.,” starring a nuclear Nicole Scherzinger, to Broadway after its triumph in London’s West End. Kit Connor and Rachel Zegler …

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John Cena to lead Mattel’s live-action ‘Matchbox’ film for Apple
3 months ago

John Cena to lead Mattel’s live-action ‘Matchbox’ film for Apple

The Hindu  

John Cena is set to headline Matchbox, a live-action film based on the iconic Mattel car toyline. While plot details are being kept under wraps, the film marks the first time Matchbox has been adapted for the big screen, even as Mattel’s other car brand, Hot Wheels, has been in Hollywood’s sights for years. The brand originated when automotive enthusiast …

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聚焦新污染物毒理学 助力健康中国 ——记东南大学王大勇教授
5 months, 3 weeks ago

聚焦新污染物毒理学 助力健康中国 ——记东南大学王大勇教授

China Daily  

不积跬步，无以至千里；不积小流，无以成江海。科研，从来都不是一蹴而就的。在王大勇教授的开拓创新的探索历程中，基于秀丽线虫的毒理学占据了他绝大部分的研究时间，或许正是因为这份专注和执着，让他在该领域成绩斐然，极具国际声望。 不忘初心 开拓进取 信念如磐，则心无畏惧；矢志不渝，则一往无前。自选择了科研那一刻起，王大勇就将所有的热情，都投入到了事业当中，他以秀丽线虫为动物模型，构建了基于秀丽线虫的毒理学相关理论体系。 秀丽线虫作为经典模式动物，个体小，且雌雄同体，雄性个体仅占群体的0.2％，可自体受精或双性生殖。1965年， Sydney Brenner教授利用秀丽线虫作为分子生物学和发育生物学研究领域的模式生物，自此，秀丽线虫走进了更多科学家的研究领域。王大勇就是其中的佼佼者。 从秀丽线虫肠道和表皮等初级生物屏障，以及环境毒物或应激暴露在秀丽线虫肠道、表皮、神经元和生殖器官等部位的毒效应诱导到毒物或应激诱导氧化应激的分子基础和参与调控毒物或应激毒效应的各种与各个层面的分子信号通路，同时涵盖了各种保护性响应信号通路、G蛋白偶联受体和离子通道、各种表观遗传调控信号通路，再到构建的在体环境毒物与应激系统暴露体系。王大勇都做出了突出贡献。 作为秀丽线虫领域的代表性学者之一，王大勇始终关注健康中国，关注生态中国的推进和落实，“作为科研人员，国家的需求，就是我们的研究方向。”他，这样说，也这样做。 面对日益增多的化学品、新污染物及其环境衍生物，新一代研究技术助力应对环境监测与风险评估是科研的重要突破方向，2022年，王大勇教授领衔完成了《基于秀丽隐杆线虫生殖毒性检测技术规范》，这是我国首个起草的一级学会（中华预防医学会）层面基于秀丽线虫的团体标准，对助力我国的化学品与环境风险评估工作，意义重大。 线虫的研究，是一个系统性的工作，所以，王大勇积极与其他团队进行深度合作，比如，他与东南大学的果蝇研究团队一起，参与组织与申报了国家果蝇与线虫生物资源库建设，并希望以此为契机，进一步夯实我国在线虫领域的研究根基，提供重要的研究平台支撑。 根据2024年最新的基于1980－2023年全球秀丽线虫文献的计量分析，根据发表文章数量与合作网络谱分析，在全球41346位相关学者中，王大勇教授与美国MIT的H. Robert Horvitz教授以及美国CIA的Paul W. Sternberg教授被评估最具有核心影响力的学者，在其中排名第二，3位学者并被推荐为秀丽线虫领域的参考作者（reference author）。 众所周知，秀丽线虫是研究动物遗传、个体发育及细胞生命活动的重要模式动物，在当代生命科学发展过程中起着举足轻重的作用，不同的科学家，有不同的研究侧重方向，王大勇则选择了毒理学，作为其研究的重要突破口。 持之以恒 放得始终 科研引领时代的发展，所以，科研人需要有高瞻远瞩的战略目光。立足当下，放眼未来，从来都是科研人的星辰大海。作为具国际影响力的探索者，王大勇教授，用诸多科研成果，诠释了不断追求卓越、勇于创新的奋斗历程。 2019年，国际上召集相关领域代表性学者，组织编写《Nematodes as model organisms》一书，该书2022年发表。这是国际上时隔40年之后，再次致力于系统总结包括秀丽线虫在内的线虫领域在基础研究与应用研究上的40年研究进展。王大勇教授作为受邀的中方研究团队，负责撰写了其中毒理学领域进展一章。 毒理学学科发展经历了传统毒理学、替代毒理学等发展时期，毒理学的研究目的是为保护生物体的健康或安全，因此，贯穿了预防为主的思想。以秀丽线虫为代表的模式生物毒理学有望克服替代毒理学中的并非全生物体系缺陷，同时兼顾了替代毒理学中部分理念。 在这样的背景下，王大勇团队在毒理学领域开展了一系列开创性研究工作，在国际学术界占据了重要的位置。基于研究团队2007－2012年研究积累，王大勇教授于2013年撰写了《模式生物毒理学》中文专著，标志着模式生物学重要理念的提出。同时，这也是目前唯一一部中文秀丽线虫研究专著，极大地推动了国内秀丽线虫在毒理学与环境科学领域的应用。 王大勇教授的实验室侧重于毒理学与环境科学研究，先后关注了纳米材料以及纳米塑料两个研究领域。在2024年针对碳纳米材料毒理学以及2023年针对石墨烯及其衍生物毒理学的全球文献计量分析中，王大勇教授在全球影响力的排名中均居第一。例如，在石墨烯及其衍生物毒理学领域，王大勇教授研究团队发表了71篇文献，被引用2014次。在2024年针对环境纳米塑料的全球文献计量分析中，王大勇教授在全球影响力的排名中同样居于第一的位置。 基于研究团队在纳米毒理学领域的系统研究积累，王大勇教授先后撰写了《Nanotoxicology in Caenorhabditis elegans》（2018）、《Molecular Toxicology in Caenorhabditis elegans》（2019）、《Target Organ Toxicology in Caenorhabditis elegans》（2019）等英文专著。同时，相关研究工作获得了教育部自然科学奖一等奖、天津市科技进步奖一等奖、中华预防医学会科学技术奖二等奖、环境保护部环境保护科学技术奖三等奖等奖励。 科研是永无止境的，随着王大勇在纳米塑料毒理学领域的深耕和积累，2020年与2022年又先后撰写了《Exposure Toxicology in Caenorhabditis elegans》与《Toxicology at Environmentally Relevant Concentrations in Caenorhabditis elegans》等英文专著。这些系列英文专著的发表，引起了国际上的广泛关注，进一步引起对于模式生物学这一重要理念的重视，同时标志着基于秀丽线虫毒理学理论的系统建成。 在肩负其科研重任的同时，王大勇还积极履行社会责任。作为致公党江苏省委东南大学二支部主委，他秉承“侨海报国、致力为公”致公党员的初衷，向致公党江苏省委提交了多篇系列调研报告，并作为政协提案进一步提交；围绕生态中国建设，先后提交了“关于进一步加强大气治理，减轻雾霾危害的建议”、“加强农用生物可降解塑料污染监管，推动生态中国建设”等提案；围绕特殊儿童的关爱，先后提交了“自闭症儿童随班就读存在的问题与对策建议”、“关于推动自闭症等特殊儿童随班就读相关人事制度建设的调研；2022年，王大勇教授被致公党江苏省委评为“为“强富美高”新江苏建设做贡献”先进个人。 路遥，不改其志；志远，不忘初衷。心怀创新的人，方能翱翔于科研世界。作为秀丽线虫研究领域的探索者，王大勇从未忘记自己的初心和使命，”秀丽线虫的相关研究，都是为了认知生命及其应用。“为了这个目标，他将继续深耕探索，继续用更多的科研成果，揭示更多关于秀丽线虫的生命”真相“。（文／李杰） 人物简介 王大勇，东南大学教授，博士生导师，入选2020－2023年度爱思唯尔中国高被引学者。侧重于利用经典模式动物秀丽线虫开展毒理学相关研究工作，具体的研究方向包括纳米毒理学、新污染物毒理学等。围绕该研究主题，已发表相关学术论文300余篇；提出了模式生物毒理学的观念，并构建了基于秀丽线虫的毒理学系统理论框架。 【责任编辑：蔡东海】

Caenorhabditis 助力健康中国 记东南大学王大勇教授
Joe Biden says ‘principle that there are no kings in America’ changed after SC's ruling on Donald Trump
5 months, 3 weeks ago

Joe Biden says ‘principle that there are no kings in America’ changed after SC's ruling on Donald Trump

Hindustan Times  

President Joe Biden has taken to X to denounce the US Supreme Court’s ruling on Donald Trump, saying it “fundamentally changed” an important principle. Joe Biden says ‘principle that there are no kings in America’ changed after SC's ruling on Donald Trump In an X post, Biden wrote, “This nation was founded on the principle that there are no kings …

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Trump blasts Biden over ‘bloodshed and crime’ at Philadelphia rally: ‘Unsafest border in the history of the world’
6 months ago

Trump blasts Biden over ‘bloodshed and crime’ at Philadelphia rally: ‘Unsafest border in the history of the world’

Hindustan Times  

Donald Trump attacked Joe Biden on Saturday night, June 22, as he rallied on the Temple University campus in Philadelphia. Donald Trump blasts Joe Biden over ‘unsafest border’ at Philadelphia rally “Less than four years ago, we were a great nation,” the former president told a crowd at Liacouras Center. “And we will soon be a great nation again.” Trump …

Border Trump Philadelphia Biden Unsafest Border Blasts Joe
In Washington, D.C., the city’s ‘forgotten river’ cleans up, slowly
6 months, 2 weeks ago

In Washington, D.C., the city’s ‘forgotten river’ cleans up, slowly

Associated Press  

WASHINGTON — Bruce Holmes, 65, grew up fishing on the Anacostia River, a 9-mile urban waterway that flows through Washington, D.C. and parts of Maryland, and has long been defined by pollution and neglect. “There are still challenges,” she said, “but people feel more connected to the river.” A volunteer uses a scale to weigh trash collected on the bank …

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Nicholas Galitzine to play He-Man in live-action 'Masters of the Universe' movie
6 months, 3 weeks ago

Nicholas Galitzine to play He-Man in live-action 'Masters of the Universe' movie

Hindustan Times  

Los Angeles, "The Idea of You" star Nicholas Galitzine will play He-Man in the upcoming live-action feature film "Masters of the Universe", based on the iconic Mattel franchise. Nicholas Galitzine to play He-Man in live-action 'Masters of the Universe' movie “Masters of the Universe” is based on Mattel’s famous toy line that spawned a successful animated TV series as well …

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Travis Knight to direct 'Master of the Universe' movie for Amazon MGM Studios and Mattel Films
7 months, 3 weeks ago

Travis Knight to direct 'Master of the Universe' movie for Amazon MGM Studios and Mattel Films

Hindustan Times  

Los Angeles, The live-action movie adaptation of "Masters of the Universe" series is moving forward at Amazon MGM Studios with Travis Knight coming aboard to direct the project. According to entertainment news outlet Variety, Amazon MGM Studios and Mattel Films have set the project for worldwide theatrical release on June 5, 2026. Knight, best known for directing "Kubo and the …

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Review: ‘Cabaret’ with a kinetic Eddie Redmayne can’t redeem a faltering Broadway revival
8 months ago

Review: ‘Cabaret’ with a kinetic Eddie Redmayne can’t redeem a faltering Broadway revival

LA Times  

If ambience were the secret to theatrical success, the new Broadway revival of “Cabaret” that opened on Sunday at the August Wilson Theatre would be the hit of the year. The theater’s traditional proscenium stage, which Lea Michele not so long ago set ablaze in her performance as Fanny Brice in the revival of “Funny Girl,” has been reconfigured into …

Performance Broadway Production Cabaret Musical Berlin Eddie Redmayne
Death row inmate faces ‘surgery without anesthesia’ if good vein isn’t found
8 months, 2 weeks ago

Death row inmate faces ‘surgery without anesthesia’ if good vein isn’t found

The Independent  

The latest headlines from our reporters across the US sent straight to your inbox each weekday Your briefing on the latest headlines from across the US Your briefing on the latest headlines from across the US SIGN UP I would like to be emailed about offers, events and updates from The Independent. Read our privacy policy A man due for …

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Millie Bobbie Brown's Stranger Things co-star Matthew Modine to officiate her wedding
9 months ago

Millie Bobbie Brown's Stranger Things co-star Matthew Modine to officiate her wedding

Hindustan Times  

Millie Bobbie Brown is letting her ‘Papa’ officiate her wedding to boyfriend Jake Bongiovi. Matthew plays Dr. Martin Brenner, Eleven’s ‘Papa,’ on the hit Netflix sci-fi series Stranger Things. Millie Bobbie Brown and Matthew Modine have starred in the hit Netflix series Stranger Things. What Matthew said In the new interview, Matthew said: “I have one of those licenses to …

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Millie Bobby Brown’s wedding will be officiated by her Stranger Things co-star
9 months ago

Millie Bobby Brown’s wedding will be officiated by her Stranger Things co-star

The Independent  

Stay ahead of the curve with our weekly guide to the latest trends, fashion, relationships and more Stay ahead of the curve with our weekly guide to the latest trends, fashion, relationships and more Stay ahead of the curve with our weekly guide to the latest trends, fashion, relationships and more SIGN UP I would like to be emailed about …

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Negotiators reach spending deal but timeline is tight to avoid shutdown
9 months ago

Negotiators reach spending deal but timeline is tight to avoid shutdown

NPR  

Negotiators reach spending deal but timeline is tight to avoid shutdown Enlarge this image toggle caption Tom Brenner/Getty Images Tom Brenner/Getty Images House Republican leaders struck a deal Monday evening with the White House on a bill to fund the Department of Homeland Security, paving the way for six spending bills to pass by the end of the week, according …

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Tired of diesel fumes, these moms are pushing for electric school buses
10 months ago

Tired of diesel fumes, these moms are pushing for electric school buses

Associated Press  

Areli Sanchez’s daughter, Aida, used to be one of 20 million American kids who ride a diesel bus to school each day. In hard-hit, or environmental justice neighborhoods, he said, “you’re removing at least some of that by putting electric school buses in the rotation.” Some school districts have switched to newer versions of diesel buses, which are more efficient …

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How a magician who has never voted found himself at the center of an AI political scandal
10 months ago

How a magician who has never voted found himself at the center of an AI political scandal

CNN  

CNN — A New Orleans street magician who has no fixed address, has never voted and claims to hold a world record in fork bending might seem like an unlikely candidate to be involved in a high-tech political scandal. Carpenter said that he didn’t know how the audio would be used and was “heartbroken” that his work could have convinced …

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Column: Still searching for the fountain of youth? Don’t drown in all the hype
10 months, 1 week ago

Column: Still searching for the fountain of youth? Don’t drown in all the hype

LA Times  

Bryan Johnson speaks to people before leading them on a hike at Temescal Canyon trail in Pacific Palisades in January. Charles Brenner, an acclaimed authority on metabolism and disease, first contacted me a year ago to say, “I’m very bothered by bulls— claims in longevity science.” The City of Hope biochemist has used science to poke holes in one life-extension …

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US strikes Iran linked targets after Jordan retaliation: 10 points you must know
10 months, 3 weeks ago

US strikes Iran linked targets after Jordan retaliation: 10 points you must know

Hindustan Times  

In a massive air raid on Iran-backed militants in Iraq and Syria, US Air Force hit over 80 targets with more than 125 bombs in retaliation to a deadly drone strike targeting an American base in Jordan last Sunday, resulting in the unfortunate loss of three U.S. service members. REUTERS/Tom Brenner/File Photo The US president, Joe Biden, said the attack …

Syria Iraq Jordan Us Strikes
Even Barbie agrees! Margot Robbie and Greta Gerwig's Oscars snub was disappointing says Barbara Handler - who inspired the iconic Mattel doll
11 months ago

Even Barbie agrees! Margot Robbie and Greta Gerwig's Oscars snub was disappointing says Barbara Handler - who inspired the iconic Mattel doll

Daily Mail  

The woman who inspired the Barbie doll is upset that the actress Margot Robbie and the film's director Greta Gerwig did not get nominated for Academy Awards for their work on the summer blockbuster. Barbara Handler, 82, who inspired the Barbie doll, is upset that the actress Margot Robbie and the film's director Greta Gerwig did not get nominated for …

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The Enfield Haunting review: Catherine Tate’s ghostly tale is epically, almost thrillingly bad
11 months, 2 weeks ago

The Enfield Haunting review: Catherine Tate’s ghostly tale is epically, almost thrillingly bad

The Independent  

Telly star Catherine Tate must be rueing the day she signed up to The Enfield Haunting. Playwright and Casualty co-creator Paul Unwin dramatising an intriguing real-life 1970s London poltergeist case in the atmospheric confines of the West End’s Ambassadors Theatre: what’s not to like? Here, Tate plays Peggy, an Enfield single mum who’s beset by supernatural goings on, the actor’s …

Tate Enfield Unwin Ghostly Tale
Golden Globes 2024: Margot Robbie channels 1977 Superstar Barbie in sequin hot pink Armani dress and matching tulle boa wrap
11 months, 2 weeks ago

Golden Globes 2024: Margot Robbie channels 1977 Superstar Barbie in sequin hot pink Armani dress and matching tulle boa wrap

Daily Mail  

Margot Robbie channeled Barbie once again as she arrived to the star-studded Golden Globes 2024 red carpet, held at the Beverly Hilton Hotel on Sunday. Robbie is nominated tonight for Best Performance by a Female Actor in a Motion Picture – Musical or Comedy for her lead role in Barbie. Margot Robbie channeled Barbie once again as she arrived to …

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