A Drug to Treat Aging May Not Be a Pipe Dream
2 years, 2 months ago

A Drug to Treat Aging May Not Be a Pipe Dream

Wired  

Life expectancy in the best-performing countries has been increasing by three months per year every year since the early 1800s. Thanks to medical advances, we’ve gradually found ways to avoid and treat such causes of death; the end result is perhaps humanity’s greatest ever achievement—we’ve literally doubled what it means to be human, increasing lifespans from 40 to 80 years. This is because, counterintuitive though it may sound, the chief risk factor for most of the modern world’s leading killers is the aging process itself: Cancer, heart disease, dementia, and many more health problems become radically more common as we get older. Scientists now have a good handle on what causes us to age, biologically speaking: The so-called “hallmarks” of the aging process range from damage to our DNA—the instruction manual within each of our cells—to proteins that misbehave because of alterations to their chemical structure. One strong contender is “senolytics,” a class of treatments that targets aged cells—which biologists call senescent cells—that accumulate in our bodies as we age.

Aging  process  drug  pipe  aging  cancer  death  2023  targets  dream  treat  risk  diseases  worlds

History of this topic

The scientific fight over whether aging is a disease
2 months ago

The scientific fight over whether aging is a disease

Live Mint  

A small but growing movement of scientists wants to classify aging as a disease. Others worry calling aging a disease could lead to financial exploitation by the anti-aging industry, capitalizing on quick fixes to “cure" aging. If physicians start to code and treat aging like a disease, they might be more likely to write off patients’ treatable conditions as mere …

I'm a longevity doctor - here are the supplements I recommend to reverse aging
3 months ago

I'm a longevity doctor - here are the supplements I recommend to reverse aging

Daily Mail  

Longevity expert Dr Michael Aziz has revealed the two dozen supplements he believes can roll back time and actually reverse the aging process. Dr Michael Aziz reveals how to reset aging's biological markers to extend both lifespan and health A docuseries on Netflix titled Live to 100: Secrets of the Blue Zones, delved into five places with 'blue zone' status: …

‘Supermodel granny’ drug could be secret to longer-life, scientists say
8 months, 1 week ago

‘Supermodel granny’ drug could be secret to longer-life, scientists say

The Independent  

The best of Voices delivered to your inbox every week - from controversial columns to expert analysis Sign up for our free weekly Voices newsletter for expert opinion and columns Sign up to our free weekly Voices newsletter Please enter a valid email address Please enter a valid email address SIGN UP I would like to be emailed about offers, …

Aging Might Not Be Inevitable
9 months ago

Aging Might Not Be Inevitable

Wired  

In 1997, a French woman named Jeanne Calment died at the age of 122. “Nobody else has lived past 120 since she died,” says Venki Ramakrishnan, the Nobel Prize–winning biologist and author of Why We Die. “If you’re a smaller species, there’s no point spending a lot of resources maintaining and repairing the body because the likelihood of being eaten …

First drug that targets 'traffic controller' cells in the brain could be a breakthrough in slowing progression of dementia, scientists say
10 months ago

First drug that targets 'traffic controller' cells in the brain could be a breakthrough in slowing progression of dementia, scientists say

Daily Mail  

A team of scientists have developed a potentially breakthrough dementia drug that could prolong the life of brain cells — and may mark a new frontier of treatment for the disease. Scientists from Ontario, Stanford University and the University of California found a twice-daily pill could reduce levels of a harmful brain protein called amyloid — one of the main …

Social Media Claims This FDA-Approved Pill Can Slow Down Aging. Can It?
11 months, 2 weeks ago

Social Media Claims This FDA-Approved Pill Can Slow Down Aging. Can It?

Huff Post  

Kouzou Sakai for HuffPost Across social media, health influencers claim that rapamycin can slow down aging in humans. The excitement around rapamycin as a longevity drug comes after studies showed years ago that low doses of rapamycin could increase the life span of mice by roughly 14%, said Dr. Elena Volpi, the director of the Sam and Ann Barshop Institute …

Want to live longer? Three top anti-ageing researchers share their tips on how to turn back the clock (and it doesn't just involve quitting smoking)
1 year, 7 months ago

Want to live longer? Three top anti-ageing researchers share their tips on how to turn back the clock (and it doesn't just involve quitting smoking)

Daily Mail  

You can live 15 years longer by eating healthily, not smoking and exercising Scientists are developing drugs that remove 'zombie cells' which cause disease Immortality might still be a concept in the realm of science fiction or the pipe dreams of billionaires. Senescent cells — dubbed 'zombie cells' — are cells that eventually stop dividing, then accumulate, releasing compounds in …

Scientists hail breakthrough as drug proven to slow Alzheimer’s disease
2 years, 3 months ago

Scientists hail breakthrough as drug proven to slow Alzheimer’s disease

The Independent  

Scientists are hailing a historic step in the fight against Alzheimer’s, after a drug was proven to slow the disease in long-awaited clinical trials. Scientists also used blood tests and brain scans to search for levels of amyloid among the participants – discovering that they had fallen so significantly in those given lecanemab that some patients no longer technically met …

Forever young: The science of disrupting death and growing old gracefully
2 years, 8 months ago

Forever young: The science of disrupting death and growing old gracefully

The Independent  

Heart disease, strokes, cancer and dementia are the four horsemen of our apocalypse. Computational biologist, Andrew Steele explains why that’s a common misconception: longevity might be a by-product of anti-ageing research but the real objective is extending healthy lifespans and the years we are free of debilitating disease: “Cancers, heart diseases and strokes are proxy wars and usually the precursor …

Fascinating picture shows anti-ageing drugs really do work
5 years, 11 months ago

Fascinating picture shows anti-ageing drugs really do work

Daily Mail  

A fascinating picture of two very different mice shows anti-ageing drugs really do work. Otherwise healthy cells are thought to age due to the accumulation of senescent cells, which may trigger inflammation or release harmful chemicals. Six trials testing senolytic drugs in humans are underway, with researchers being 'optimistic' the medication may be available in as little as two years …

The ambitious quest to cure ageing like a disease
7 years, 1 month ago

The ambitious quest to cure ageing like a disease

BBC  

The ambitious quest to cure ageing like a disease Getty Images Could humans be treated for ageing like any other disease? In our Tomorrow’s World podcast episode about ageing, one of the leading figures in human longevity research, Aubrey De Grey, tells us how similar increases in lifespan could be achieved in humans. We want to fix the things we …

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