CRISPR used to treat two human cancer patients for the first time in UPenn study
5 years, 8 months ago

CRISPR used to treat two human cancer patients for the first time in UPenn study

Firstpost  

Gene-editing technology CRISPR is finally moving out laboratories and into clinical settings around the world. Three years after have passed since the National Institute of Health gave a research team at the University of Pennsylvania the green-light to begin trials for gene-editing technology CRISPR in humans. Researchers at UPenn have used CRISPR to treat two cancer patients so far, the spokesperson told NPR. “Findings from this research study will be shared at an appropriate time via medical meeting presentation or peer-reviewed publication,” a spokesperson told NPR. But beyond the cancer study, researchers in the West are also launching other scientific efforts carefully designed at using CRISPR to treat diseases.

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History of this topic

RNA editing is the next frontier in gene therapy – here’s what you need to know
1 month, 2 weeks ago

RNA editing is the next frontier in gene therapy – here’s what you need to know

Raw Story  

The United States Food and Drug Administration has just approved the first-ever clinical trial that uses CRISPR-Cas13 RNA editing. Thanks to recent advances, we now have the tools to directly change someone’s DNA – this has paved the way for gene editing as a type of gene therapy. RNA editing doesn’t permanently change a person’s DNA, but rather alters the …

The First Crispr Treatment Is Making Its Way to Patients
1 month, 3 weeks ago

The First Crispr Treatment Is Making Its Way to Patients

Wired  

Nearly a year after its approval, the first medical treatment that uses the Nobel Prize–winning technology Crispr is now being given to patients. Called Casgevy, the gene-editing treatment is for people with sickle cell disease and a related blood disorder called beta thalassemia. “Cagevy has been enthusiastically received by patients, physicians, and policymakers, and the launch is gathering momentum across …

How CRISPR can edit entire microbial populations in our gut
3 months, 1 week ago

How CRISPR can edit entire microbial populations in our gut

NPR  

How CRISPR can edit entire microbial populations in our gut Part 4 of the TED Radio Hour episode Augmenting Humans. Jennifer Doudna's gene-editing technology CRISPR can now manipulate populations of microbes. Together with her collaborator Emmanuelle Charpentier, Doudna has developed a technology called CRISPR-Cas9 that enables genome editing in any living cell. Web Resources Related TED Bio: Jennifer DoudnaRelated TED …

Gene therapy trials treat inherited blindness and deafness
8 months ago

Gene therapy trials treat inherited blindness and deafness

Hindustan Times  

Scientists have restored vision and hearing in people born with congenital blindness or deafness in two separate gene therapy trials A new CRISPR gene editing called EDIT-101 has successfully restored vision in some patients with congenital blindness A British toddler born deaf has become the first person to have their hearing restored via gene therapy. CRISPR gene therapy restores vision …

Scientists Make Breakthrough, Use Crispr To Eliminate HIV From Infected Cells
9 months, 3 weeks ago

Scientists Make Breakthrough, Use Crispr To Eliminate HIV From Infected Cells

News 18  

A team of researchers from the University of Amsterdam said they have successfully eliminated HIV from infected cells with the aid of Nobel Prize-winning Crispr gene-editing technology. Dr. Jonathan Stoye, a virus expert at the Francis Crick Institute in London, stated that eliminating HIV from all potential host cells in the body posed significant challenges, while speaking to the UK …

With CRISPR poised to revolutionise therapy, a pause to consider ethical issues
11 months ago

With CRISPR poised to revolutionise therapy, a pause to consider ethical issues

The Hindu  

“We will each write a ghost story”, said Lord Byron; and his proposition was acceded to. With the first gene editing technology securing approval for the treatment of sickle cell anemia and beta-thalassemia, we transcend into a new revolutionary phase. Casgevy and Lyfgenia, the two cell-based gene therapies approved by the Food and Drug Administration for sickle cell anemia treatment …

Gene Editing Needs to Be for Everyone
1 year ago

Gene Editing Needs to Be for Everyone

Wired  

At the end of 2023, we witnessed an important moment in the history of medicine: For the first time, the US Food and Drug Administration approved a therapy that uses Crispr gene editing. This new therapy was developed by Crispr Therapeutics and Vertex Pharmaceuticals to treat sickle cell disease, an ailment caused by a single-letter mutation in the genetic code …

The Age of Crispr Medicine Is Here
55 years ago

The Age of Crispr Medicine Is Here

Wired  

Jimi Olaghere used to end up in the emergency room so often that the hospital reserved a bed for him. “It was a circus, bouncing from specialist to specialist and constantly desecrating my body with endless amounts of prescription pills, all in the hopes of finding a sliver of what it feels like to be alive,” Olaghere told an advisory …

The era of CRISPR therapeutics is here – what can we expect? | Explained
1 year ago

The era of CRISPR therapeutics is here – what can we expect? | Explained

The Hindu  

Imagine a future where genetic anomalies can be precisely targeted and corrected using genome editing – a giant leap from our ability to sequence or read human genomes two decades ago. The 2020 Nobel Prize didn’t only honour the researchers: it also symbolised the start of a time in which people couldn’t just read human genomes but also edit or …

The First Crispr Medicine Is Now Approved in the US
55 years ago

The First Crispr Medicine Is Now Approved in the US

Wired  

“This is a terrible disease,” says Samarth Kulkarni, president and CEO of Crispr Therapeutics. Casgevy uses the Nobel Prize–winning technology Crispr to modify patients’ cells so that they produce healthy hemoglobin instead. Of the 31 patients followed for two years, 29 have been free of pain crises for at least a year after receiving a single dose of their own …

Jennifer Doudna Believes Crispr Is for Everyone
55 years ago

Jennifer Doudna Believes Crispr Is for Everyone

Wired  

It’s been a monumental year for Crispr, the molecular tool scientists use to edit genetic material. This November, the United Kingdom authorized the first medical treatment using Crispr gene editing, giving people with sickle cell disease new opportunities to receive a one-time therapy to prevent episodes of terrible pain. “It’s expensive,” Jennifer Doudna, the pioneering biochemist who won a Nobel …

The First Crispr Medicine Just Got Approved
55 years ago

The First Crispr Medicine Just Got Approved

Wired  

The first medical treatment that uses Crispr gene editing was authorized Thursday by the United Kingdom. The one-time therapy, which will be sold under the brand name Casgevy, is for patients with sickle cell disease and a related blood disorder called beta thalassemia, both of which are inherited. Developed by Vertex Pharmaceuticals of Boston and Crispr Therapeutics of Switzerland, Casgevy …

Researchers link death in gene-editing study to a virus used to deliver the treatment, not CRISPR
1 year, 7 months ago

Researchers link death in gene-editing study to a virus used to deliver the treatment, not CRISPR

Associated Press  

The lone volunteer in a gene-editing study targeting a rare form of Duchenne muscular dystrophy likely died after having a reaction to the virus that delivered the therapy in his body, researchers concluded in an early study. But researchers said the virus — one used to carry treatment into the body because it doesn’t usually make people sick — combined …

Crispr Wants to Feed the World
1 year, 11 months ago

Crispr Wants to Feed the World

Wired  

Ten years after its discovery, the implications of Crispr genome editing are profound and far-reaching, and we are only getting started. For instance, following on the heels of the initial clinical trial results, the first agricultural applications using Crispr have recently entered the market: A US Food and Drug Administration–approved edit to cattle genes re-creates a slick coat that is …

Death in US gene therapy study sparks search for answers
2 years, 2 months ago

Death in US gene therapy study sparks search for answers

Associated Press  

The lone volunteer in a unique study involving a gene-editing technique has died, and those behind the trial are now trying to figure out what killed him. “But then, to the extent that we can, we must learn as much as we can to carve out a path forward.” FEW ANSWERS YET A statement from Cure Rare Disease said multiple …

Death in CRISPR gene therapy study sparks search for answers
2 years, 2 months ago

Death in CRISPR gene therapy study sparks search for answers

The Independent  

For free real time breaking news alerts sent straight to your inbox sign up to our breaking news emails Sign up to our free breaking news emails Sign up to our free breaking news emails SIGN UP I would like to be emailed about offers, events and updates from The Independent. And Fyodor Urnov, a CRISPR expert at the Innovative …

A Bold Effort to Cure HIV—Using Crispr
2 years, 3 months ago

A Bold Effort to Cure HIV—Using Crispr

Wired  

In July, an HIV-positive man became the first volunteer in a clinical trial aimed at using Crispr gene editing to snip the AIDS-causing virus out of his cells. “What we’re trying to do is return the cell to a near-normal state,” says Daniel Dornbusch, CEO of Excision BioTherapeutics, the San Francisco-based biotech company that’s running the trial. “HIV is a …

Can Genetic Modification Technology CRISPR be Applied to Covid-19 diagnostics?
3 years, 4 months ago

Can Genetic Modification Technology CRISPR be Applied to Covid-19 diagnostics?

News 18  

US scientists have repurposed genetic modification technology CRISPR to identify antibodies in patient blood samples in a move that could inspire a new class of medical diagnostics, particularly in the treatment of Covid-19. The technology involves customisable collections of proteins which are attached to a variant of Cas9, the protein at the heart of CRISPR, that will bind to DNA …

NASA Astronauts Used CRISPR Gene Editing Technology For the First Time in Space
3 years, 6 months ago

NASA Astronauts Used CRISPR Gene Editing Technology For the First Time in Space

News 18  

For human beings, going to space may seem the most exciting thing, but our bodies do not enjoy it that much. However, previous research has found that how cells pick a particular repair strategy can be influenced by the microgravity conditions in space. To study the DNA repair process in space, scientists have developed a new technique that uses CRISPR/Cas9 …

New CRISPR tech can revolutionise gene therapy, renew hope for treating genetic diseases
3 years, 11 months ago

New CRISPR tech can revolutionise gene therapy, renew hope for treating genetic diseases

Firstpost  

The day a muddled mob stormed the US Capitol building, a team of American researchers published a paper in Nature that signified a landmark in gene therapy. The head of the US National Institutes of Health, Francis Collins had joined forces with Harvard University professor David Liu and others to tackle progeria, a genetic disorder that causes children to age …

Gene-editing treatment shows promise for sickle cell disease
4 years, 1 month ago

Gene-editing treatment shows promise for sickle cell disease

Associated Press  

Scientists are seeing promising early results from the first studies testing gene editing for painful, inherited blood disorders that plague millions worldwide, especially Black people. Doctors hope the one-time treatment, which involves permanently altering DNA in blood cells with a tool called CRISPR, may treat and possibly cure sickle cell disease and beta thalassemia. In sickle cell, defective hemoglobin leads …

CRISPR gene editing can cause unwanted changes in human embryos, study finds
4 years, 2 months ago

CRISPR gene editing can cause unwanted changes in human embryos, study finds

Firstpost  

Instead of addressing genetic mutations, the CRISPR-Cas9 technology appeared to wreak genetic havoc in about half the specimens that the researchers examined A powerful gene-editing tool called CRISPR-Cas9, which this month nabbed the Nobel Prize in Chemistry for two female scientists, can cause serious side effects in the cells of human embryos, prompting them to discard large chunks of their …

Lab tests show risks of using CRISPR gene editing on embryos
4 years, 2 months ago

Lab tests show risks of using CRISPR gene editing on embryos

The Independent  

For free real time breaking news alerts sent straight to your inbox sign up to our breaking news emails Sign up to our free breaking news emails Sign up to our free breaking news emails SIGN UP I would like to be emailed about offers, events and updates from The Independent. Read our privacy policy A lab experiment aimed at …

Crispr: What is genome editing? All you need to know about Nobel-winning controversial technology
4 years, 3 months ago

Crispr: What is genome editing? All you need to know about Nobel-winning controversial technology

India Today  

Two women -- Emmanuelle Charpentier and Jennifer Doudna -- were awarded the 2020 Nobel Prize for chemistry by the Nobel Committee on Wednesday. The duo received the Nobel Prize in chemistry award for developing a method of genome editing, or gene editing, likened to "molecular scissors" that offers the promise of one day curing inherited diseases and even cancer. A …

What is CRISPR and why is it controversial?
4 years, 3 months ago

What is CRISPR and why is it controversial?

CNN  

CNN — Two women have won the Nobel prize in chemistry for the development of a revolutionary gene editing tool that’s been described as “rewriting the code of life.” The technique discovered by Emmanuelle Charpentier, the director at the Max Planck Institute for Infection Biology, and Jennifer A. Doudna, a biochemist at the University of California Berkeley, is known as …

Too Soon to Give Green Signal to Techniques of Genome Editing for Human Embryo, Say Scientists
4 years, 4 months ago

Too Soon to Give Green Signal to Techniques of Genome Editing for Human Embryo, Say Scientists

News 18  

Techniques to genetically-edit human embryos should not be used until they are proved to be reliable and safe, an international commission said Thursday, in the wake of a scandal over gene-modified babies in China two years ago. Experts from the commission of the US National Academy of Medicine, US National Academy of Sciences, and Britain’s Royal Society said heritable genome …

Scientists claim to have uses CRISPR for the first time to treat a patient who was blind
4 years, 10 months ago

Scientists claim to have uses CRISPR for the first time to treat a patient who was blind

Firstpost  

They said that it will take up to a month to see if this surgery worked and has restored the patient’s vision. Scientists say they have used the gene-editing tool CRISPR inside someone’s body for the first time, a new frontier for efforts to operate on DNA, the chemical code of life, to treat diseases. “We think it could open …

First CRISPR gene editing trial in cancer patients points to safety of technique in medical treatments
4 years, 10 months ago

First CRISPR gene editing trial in cancer patients points to safety of technique in medical treatments

Firstpost  

Back in April 2019, an experimental study underway at the University of Pennsylvania made news for its success in using gene editing to treat a form of malignant cancer. Researchers genetically-altered immune cells to encourage them to attack and destroy cancer cells, and managed to cure a patient of sarcoma – a cancer of the soft tissues like muscle, tendons, …

Crispr'd Cells Show Promise in First US Human Safety Trial
55 years ago

Crispr'd Cells Show Promise in First US Human Safety Trial

Wired  

It’s been over three years since US regulators greenlit the nation’s first in-human test of Crispr’s disease-fighting potential, more than three years of waiting to find out if the much-hyped gene-editing technique could be safely used to beat back tough-to-treat cancers. These cells successfully joined up with the rest of each person’s immune system and could still be found circulating …

Molecular Scissors Could Help Keep Some Viral Illnesses At Bay
5 years, 1 month ago

Molecular Scissors Could Help Keep Some Viral Illnesses At Bay

NPR  

Molecular Scissors Could Help Keep Some Viral Illnesses At Bay Enlarge this image Susanna M. Hamilton/Broad Communications Susanna M. Hamilton/Broad Communications It's not easy to treat viral infections. Sponsor Message What's different is that the antiviral approach researchers at the Broad Institute in Cambridge are using involves a form of CRISPR called Cas13 that targets specific regions of RNA, not …

CRISPR Approach To Fighting Cancer Called 'Promising' In 1st Safety Test
5 years, 2 months ago

CRISPR Approach To Fighting Cancer Called 'Promising' In 1st Safety Test

NPR  

CRISPR Approach To Fighting Cancer Called 'Promising' In 1st Safety Test Enlarge this image toggle caption Jure Gasparic/EyeEm/Getty Images Jure Gasparic/EyeEm/Getty Images The powerful gene-editing technique known as CRISPR has raised a lot of hope in recent years for its potential to offer new ways to treat many diseases, including cancer. On Wednesday, researchers revealed data from the first study …

Cervical cancer 'cure' closer with gene-editing breakthrough, scientists say
5 years, 3 months ago

Cervical cancer 'cure' closer with gene-editing breakthrough, scientists say

ABC  

Queensland researchers are hailing a world-first "cure" for cervical cancer, having killed off tumours in mice using CRISPR gene-editing technology. Key points: Scientists say all the treated mice had a 100 per cent survival rate The Griffith University scientists are working towards performing human trials of the gene therapy in the next five years Researchers say the breakthrough means other …

CRISPR Gene Editing May Offer Path To Cure For HIV, First Published Report Shows
5 years, 4 months ago

CRISPR Gene Editing May Offer Path To Cure For HIV, First Published Report Shows

NPR  

CRISPR Gene Editing May Offer Path To Cure For HIV, First Published Report Shows Enlarge this image MOLEKUUL/SCIENCE PHOTO LIBRARY/Getty Images/Science Photo Libra MOLEKUUL/SCIENCE PHOTO LIBRARY/Getty Images/Science Photo Libra There's been a lot of excitement lately that the powerful gene-editing technique CRISPR could offer a new way to treat health problems ranging from cancer to blindness. Chinese scientists have published …

Doctors In The U.S. Use CRISPR Technique To Treat A Genetic Disorder For The 1st Time
5 years, 5 months ago

Doctors In The U.S. Use CRISPR Technique To Treat A Genetic Disorder For The 1st Time

NPR  

Doctors In The U.S. Use CRISPR Technique To Treat A Genetic Disorder For The 1st Time For the first time, doctors have used the gene-editing technique CRISPR to treat a genetic disorder in the U.S. STEIN: Yeah, so Victoria has sickle cell disease, and it's a terrible genetic disease that primarily affects African Americans in the United States. And instead …

In A 1st, Doctors In U.S. Use CRISPR Tool To Treat Patient With Genetic Disorder
5 years, 5 months ago

In A 1st, Doctors In U.S. Use CRISPR Tool To Treat Patient With Genetic Disorder

NPR  

In A 1st, Doctors In U.S. Use CRISPR Tool To Treat Patient With Genetic Disorder Enlarge this image toggle caption Meredith Rizzo/NPR Meredith Rizzo/NPR Updated at 4:05 p.m. Enlarge this image toggle caption Meredith Rizzo/NPR Meredith Rizzo/NPR "Sometimes it feels like lightning strikes in my chest and real sharp pains all over," Gray says. "It's a gene that tells the …

CRISPR will bring huge shifts to agriculture, food sectors in next 5 years says founder
5 years, 8 months ago

CRISPR will bring huge shifts to agriculture, food sectors in next 5 years says founder

Firstpost  

Gene editing technology CRISPR has found itself in the news a whole lot since it was first invented and used in living systems in 2012 and 2013, respectively. “In the next five years, the most profound thing we’ll see in terms of CRISPR’s effects on everyday lives will be in the agricultural sector,” she told Business Insider. Memphis Meats, a …

First U.S. Patients Treated With CRISPR As Human Gene-Editing Trials Get Underway
5 years, 8 months ago

First U.S. Patients Treated With CRISPR As Human Gene-Editing Trials Get Underway

NPR  

Patients Treated With CRISPR As Human Gene-Editing Trials Get Underway Enlarge this image toggle caption Molekuul/Getty Images/Science Photo Library Molekuul/Getty Images/Science Photo Library The powerful gene-editing technique called CRISPR has been in the news a lot. Sponsor Message Research News Scientists Plan To Start Human Trials Testing CRISPR Soon Scientists Plan To Start Human Trials Testing CRISPR Soon 4:30 One …

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