Crispr: Breakthrough announced in technique of 'editing' DNA to fight off deadly illnesses
9 years, 8 months ago

Crispr: Breakthrough announced in technique of 'editing' DNA to fight off deadly illnesses

The Independent  

Sign up for our free Health Check email to receive exclusive analysis on the week in health Get our free Health Check email Get our free Health Check email SIGN UP I would like to be emailed about offers, events and updates from The Independent. Dr Marson and his colleagues used the Crispr gene-editing technique to cut and splice fragments of DNA within the chromosomes of human T-cells living in a laboratory dish – as “proof of principle” that the process is precise enough for eventual use as a clinical treatment. We have now been able to cut as well as paste pieces of the genome into human T-cells – for the first time to our knowledge.” Crispr has proved a highly accurate method of identifying precise positions on the DNA molecule and, with the help of an enzyme called Cas9, cutting the double helix strands and replacing exact sections with synthetic, healthy sequences of DNA. “Genome editing in human T-cells has been a notable challenge for the field,” Dr Marson said. open image in gallery Jennifer Doudna, a genetics researcher, at the University of California, Berkeley, March 19, 2015 Jennifer Doudna, of the University of California, Berkeley, was not only involved with the latest study, demonstrating how the technique can be used to “cut and paste” the DNA of human T-cells, but was also part of the project that first married the “guide molecule” Crispr with bacterial enzyme Cas-9, creating a powerful gene-editing tool.

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History of this topic

How CRISPR can edit entire microbial populations in our gut
5 months, 3 weeks ago

How CRISPR can edit entire microbial populations in our gut

NPR  

How CRISPR can edit entire microbial populations in our gut Part 4 of the TED Radio Hour episode Augmenting Humans. Jennifer Doudna's gene-editing technology CRISPR can now manipulate populations of microbes. Together with her collaborator Emmanuelle Charpentier, Doudna has developed a technology called CRISPR-Cas9 that enables genome editing in any living cell. Web Resources Related TED Bio: Jennifer DoudnaRelated TED …

Scientists can edit HIV from cells, hinting at cure: Report
1 year ago

Scientists can edit HIV from cells, hinting at cure: Report

India Today  

Scientists can eliminate HIV infection from cells using the powerful CRISPR technology, BBC reported. However, the delivery of these systems remains a significant issue and much more work will be needed to demonstrate results in these cell assays can happen in an entire body for a future therapy," Dr James Dixon told Science Media Centre. Virus expert Dr Jonathan Stoye …

Scientists Make Breakthrough, Use Crispr To Eliminate HIV From Infected Cells
1 year ago

Scientists Make Breakthrough, Use Crispr To Eliminate HIV From Infected Cells

News 18  

A team of researchers from the University of Amsterdam said they have successfully eliminated HIV from infected cells with the aid of Nobel Prize-winning Crispr gene-editing technology. Dr. Jonathan Stoye, a virus expert at the Francis Crick Institute in London, stated that eliminating HIV from all potential host cells in the body posed significant challenges, while speaking to the UK …

Jennifer Doudna Believes Crispr Is for Everyone
55 years, 2 months ago

Jennifer Doudna Believes Crispr Is for Everyone

Wired  

It’s been a monumental year for Crispr, the molecular tool scientists use to edit genetic material. This November, the United Kingdom authorized the first medical treatment using Crispr gene editing, giving people with sickle cell disease new opportunities to receive a one-time therapy to prevent episodes of terrible pain. “It’s expensive,” Jennifer Doudna, the pioneering biochemist who won a Nobel …

Researchers link death in gene-editing study to a virus used to deliver the treatment, not CRISPR
1 year, 9 months ago

Researchers link death in gene-editing study to a virus used to deliver the treatment, not CRISPR

The Independent  

For free real time breaking news alerts sent straight to your inbox sign up to our breaking news emails Sign up to our free breaking news emails Sign up to our free breaking news emails SIGN UP I would like to be emailed about offers, events and updates from The Independent. Read our privacy policy The lone volunteer in a …

A Bold Effort to Cure HIV—Using Crispr
2 years, 5 months ago

A Bold Effort to Cure HIV—Using Crispr

Wired  

In July, an HIV-positive man became the first volunteer in a clinical trial aimed at using Crispr gene editing to snip the AIDS-causing virus out of his cells. “What we’re trying to do is return the cell to a near-normal state,” says Daniel Dornbusch, CEO of Excision BioTherapeutics, the San Francisco-based biotech company that’s running the trial. “HIV is a …

CRISPR Scientist's Biography Explores Ethics Of Rewriting The Code Of Life
4 years ago

CRISPR Scientist's Biography Explores Ethics Of Rewriting The Code Of Life

NPR  

CRISPR Scientist's Biography Explores Ethics Of Rewriting The Code Of Life Enlarge this image toggle caption Nick Otto/The Washington Post via Getty Images Nick Otto/The Washington Post via Getty Images The Pfizer and Moderna COVID-19 vaccines are the first vaccines to be activated by mRNA — and would not have been possible without the invention of the gene editing technology …

Gene-editing treatment shows promise for sickle cell disease
4 years, 3 months ago

Gene-editing treatment shows promise for sickle cell disease

Associated Press  

Scientists are seeing promising early results from the first studies testing gene editing for painful, inherited blood disorders that plague millions worldwide, especially Black people. Doctors hope the one-time treatment, which involves permanently altering DNA in blood cells with a tool called CRISPR, may treat and possibly cure sickle cell disease and beta thalassemia. In sickle cell, defective hemoglobin leads …

CRISPR gene editing can cause unwanted changes in human embryos, study finds
4 years, 4 months ago

CRISPR gene editing can cause unwanted changes in human embryos, study finds

Firstpost  

Instead of addressing genetic mutations, the CRISPR-Cas9 technology appeared to wreak genetic havoc in about half the specimens that the researchers examined A powerful gene-editing tool called CRISPR-Cas9, which this month nabbed the Nobel Prize in Chemistry for two female scientists, can cause serious side effects in the cells of human embryos, prompting them to discard large chunks of their …

Crispr: What is genome editing? All you need to know about Nobel-winning controversial technology
4 years, 5 months ago

Crispr: What is genome editing? All you need to know about Nobel-winning controversial technology

India Today  

Two women -- Emmanuelle Charpentier and Jennifer Doudna -- were awarded the 2020 Nobel Prize for chemistry by the Nobel Committee on Wednesday. The duo received the Nobel Prize in chemistry award for developing a method of genome editing, or gene editing, likened to "molecular scissors" that offers the promise of one day curing inherited diseases and even cancer. A …

Scientists claim to have uses CRISPR for the first time to treat a patient who was blind
5 years ago

Scientists claim to have uses CRISPR for the first time to treat a patient who was blind

Firstpost  

They said that it will take up to a month to see if this surgery worked and has restored the patient’s vision. Scientists say they have used the gene-editing tool CRISPR inside someone’s body for the first time, a new frontier for efforts to operate on DNA, the chemical code of life, to treat diseases. “We think it could open …

First CRISPR gene editing trial in cancer patients points to safety of technique in medical treatments
5 years, 1 month ago

First CRISPR gene editing trial in cancer patients points to safety of technique in medical treatments

Firstpost  

Back in April 2019, an experimental study underway at the University of Pennsylvania made news for its success in using gene editing to treat a form of malignant cancer. Researchers genetically-altered immune cells to encourage them to attack and destroy cancer cells, and managed to cure a patient of sarcoma – a cancer of the soft tissues like muscle, tendons, …

Never-seen-before extracts from 'outrageous' research of disgraced scientist He Jiankui
5 years, 3 months ago

Never-seen-before extracts from 'outrageous' research of disgraced scientist He Jiankui

Daily Mail  

He Jiankui, the disgraced scientist who was internationally condemned for gene-editing twin girls, may have put the health of the children at risk by adding unintended mutations into their genetic code. Dr Vassena adds: 'The idea that editing-derived embryos may one day be able to 'control the HIV epidemic,' as the authors claim, is preposterous. 'It's almost like not editing …

CRISPR Gene Editing May Offer Path To Cure For HIV, First Published Report Shows
5 years, 6 months ago

CRISPR Gene Editing May Offer Path To Cure For HIV, First Published Report Shows

NPR  

CRISPR Gene Editing May Offer Path To Cure For HIV, First Published Report Shows Enlarge this image MOLEKUUL/SCIENCE PHOTO LIBRARY/Getty Images/Science Photo Libra MOLEKUUL/SCIENCE PHOTO LIBRARY/Getty Images/Science Photo Libra There's been a lot of excitement lately that the powerful gene-editing technique CRISPR could offer a new way to treat health problems ranging from cancer to blindness. Chinese scientists have published …

HIV cure using gene editing shows promise in animal testing
5 years, 8 months ago

HIV cure using gene editing shows promise in animal testing

The Independent  

Sign up for our free Health Check email to receive exclusive analysis on the week in health Get our free Health Check email Get our free Health Check email SIGN UP I would like to be emailed about offers, events and updates from The Independent. Clinical trials for the gene-editing component of the cure could start as early as next …

For the first time, researchers use gene editing to cure mice of HIV
5 years, 8 months ago

For the first time, researchers use gene editing to cure mice of HIV

Salon  

For the first time in history, researchers have successfully eliminated HIV from infected mice DNA. In a study published on Tuesday in Nature Communications, researchers reported a potential new way to cure HIV, a disease that affects an estimated 1.1 million people in the United States. Fortunately, life expectancy for those living with AIDS has greatly improved over the last …

CRISPR will bring huge shifts to agriculture, food sectors in next 5 years says founder
5 years, 11 months ago

CRISPR will bring huge shifts to agriculture, food sectors in next 5 years says founder

Firstpost  

Gene editing technology CRISPR has found itself in the news a whole lot since it was first invented and used in living systems in 2012 and 2013, respectively. “In the next five years, the most profound thing we’ll see in terms of CRISPR’s effects on everyday lives will be in the agricultural sector,” she told Business Insider. Memphis Meats, a …

CRISPR used to treat two human cancer patients for the first time in UPenn study
5 years, 11 months ago

CRISPR used to treat two human cancer patients for the first time in UPenn study

Firstpost  

Gene-editing technology CRISPR is finally moving out laboratories and into clinical settings around the world. Three years after have passed since the National Institute of Health gave a research team at the University of Pennsylvania the green-light to begin trials for gene-editing technology CRISPR in humans. Researchers at UPenn have used CRISPR to treat two cancer patients so far, the …

First U.S. Patients Treated With CRISPR As Human Gene-Editing Trials Get Underway
5 years, 11 months ago

First U.S. Patients Treated With CRISPR As Human Gene-Editing Trials Get Underway

NPR  

Patients Treated With CRISPR As Human Gene-Editing Trials Get Underway Enlarge this image toggle caption Molekuul/Getty Images/Science Photo Library Molekuul/Getty Images/Science Photo Library The powerful gene-editing technique called CRISPR has been in the news a lot. Sponsor Message Research News Scientists Plan To Start Human Trials Testing CRISPR Soon Scientists Plan To Start Human Trials Testing CRISPR Soon 4:30 One …

Baby-editing geneticist says a second volunteer in controversial study is pregnant
6 years, 4 months ago

Baby-editing geneticist says a second volunteer in controversial study is pregnant

Firstpost  

He said he used a gene-editing technology known as CRISPR-Cas9 to alter the embryonic genes. A Chinese scientist at the centre of an ethical storm over what he claims are the world’s first genetically edited babies said on 28 November he is proud of his work and revealed that another volunteer is pregnant as part of the research. He Jiankui, …

Facing Backlash, Chinese Scientist Defends Gene-Editing Research On Babies
6 years, 4 months ago

Facing Backlash, Chinese Scientist Defends Gene-Editing Research On Babies

NPR  

Facing Backlash, Chinese Scientist Defends Gene-Editing Research On Babies Enlarge this image toggle caption Kin Cheung/AP Kin Cheung/AP Updated at 6:15 a.m. Enlarge this image toggle caption Kin Cheung/AP Kin Cheung/AP She spoke after Harvard Medical School Dean George Daley alluded to He's claims as "missteps" that he worried might set back a highly promising field of research. "Just because …

Scientists, officials in China abhor gene editing that geneticist claims
6 years, 4 months ago

Scientists, officials in China abhor gene editing that geneticist claims

Live Mint  

Beijing/Shanghai: Chinese officials and scientists denounced on Tuesday the claims of a geneticist who said he had created the first gene-edited babies, and a hospital linked to his research suggested its ethical approval had been forged. China’s Genetics Society and the Chinese Society for Stem Cell Research said in a statement He had acted as an “individual” and his work …

World's first CRISPR gene-edited babies claimed by Chinese researcher as success
6 years, 4 months ago

World's first CRISPR gene-edited babies claimed by Chinese researcher as success

Firstpost  

Society will decide what to do next in terms of allowing or forbidding such science: Researcher. It’s “unconscionable … an experiment on human beings that is not morally or ethically defensible,” said Dr Kiran Musunuru, a University of Pennsylvania gene editing expert and editor of a genetics journal. It’s a big deal.” However, one famed geneticist, Harvard University’s George Church, …

Editing our genes
6 years, 6 months ago

Editing our genes

The Hindu  

American biochemist Jennifer Doudna, one of the pioneers of the gene editing tool Crispr-Cas9, woke up in a cold sweat after she dreamt of Adolf Hitler. In the book she co-authored, A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution, Doudna recounts the dream, and acknowledges the “truly incredible power” of the technology, “one that could …

Why DNA Is the Most Exciting Programming Language Today
6 years, 6 months ago

Why DNA Is the Most Exciting Programming Language Today

Wired  

WIRED ICON Sean Parker, Napster cofounder NOMINATES Alex Marson, biologist and infectious disease doctor at UC San Francisco When Sean Parker was young, he cofounded Napster and changed the way we listen to music. The Parker Institute for Cancer Immunotherapy, which he founded in 2016, has dedicated $250 million toward using new technologies like Crispr to teach the human body …

Why the Gene Editors of Tomorrow Need to Study Ethics Today
6 years, 6 months ago

Why the Gene Editors of Tomorrow Need to Study Ethics Today

Wired  

Two years after biochemist Jennifer Doudna helped introduce the world to the gene-editing tool known as Crispr, a 14-year-old from New Jersey turned it loose on a petri dish full of lung cancer cells, disrupting their ability to multiply. “In high school, I was all on the Crispr bandwagon,” says Jiwoo Lee, who won top awards at the 2016 Intel …

WHAT IS CRISPR-CAS9?
7 years, 3 months ago

WHAT IS CRISPR-CAS9?

Daily Mail  

The approach has been used previously to edit the HBB gene responsible for a condition called β-thalassaemia. Get ready for genetically engineered 'super chocolate': Scientists use gene editing tools to make cacao trees resistant to disease Gene-editing tool CRISPR-Cas9 could help breed cacao trees that exhibit desirable traits such as enhanced resistance to diseases, a Penn. Revolutionary gene-editing tool CRISPR …

For first time ever, scientists are able to edit DNA in human embryos through CRISPR technique!
7 years, 7 months ago

For first time ever, scientists are able to edit DNA in human embryos through CRISPR technique!

India TV News  

In a recent breakthrough, US scientists have been able to modify genes of a human embryo to correct a disease-causing mutation. "We have demonstrated the possibility to correct mutations in a human embryo in a safe way and with a certain degree of efficiency," said Juan Carlos Izpisua Belmonte, a professor in Salk's Gene Expression Laboratory and a co-author of …

Crispr Creator Jennifer Doudna on the Promises—and Pitfalls—of Easy Genetic Modification
7 years, 10 months ago

Crispr Creator Jennifer Doudna on the Promises—and Pitfalls—of Easy Genetic Modification

Wired  

For $150, you can buy a Crispr kit online and use it to engineer heartier gut bacteria in your kitchen. Easy genetic modification could mean cures for cancer, kitty-sized pigs, and, yes, designer babies. Perfect children The prospect of editing human embryos to make people super athletic and acne-free is disturbing, Doudna says. Crispr could also allow the creation of …

Scientists hail 'promising cure' for HIV after study in mice
7 years, 10 months ago

Scientists hail 'promising cure' for HIV after study in mice

The Independent  

Sign up for our free Health Check email to receive exclusive analysis on the week in health Get our free Health Check email Get our free Health Check email SIGN UP I would like to be emailed about offers, events and updates from The Independent. “To our knowledge, this study is the first to demonstrate the effective excision of HIV-1 …

Gene editing could bring an end to all inherited disease and cancer, expert says
8 years, 1 month ago

Gene editing could bring an end to all inherited disease and cancer, expert says

The Independent  

Sign up to our free weekly IndyTech newsletter delivered straight to your inbox Sign up to our free IndyTech newsletter Sign up to our free IndyTech newsletter SIGN UP I would like to be emailed about offers, events and updates from The Independent. Gene editing techniques that have been developed in recent years could be put to work to effectively …

Trends 2017: How Gene-Editing Tech Crispr Holds Great Promise and Peril for Humanity
8 years, 2 months ago

Trends 2017: How Gene-Editing Tech Crispr Holds Great Promise and Peril for Humanity

Wired  

Biologists worldwide have fallen in love with Crispr for its rapid, efficient gene-editing powers. The Crispr startup Editas Medicine expects to launch its first clinical trial, for a congenital eye disease that causes blindness, this year. And the US National Institutes of Health has already approved the first wide-scale trial of a Crispr-based cancer treatment: Scientists at the University of …

CRISPR-Cas9: Chinese scientists to conduct live human gene-editing trial
8 years, 8 months ago

CRISPR-Cas9: Chinese scientists to conduct live human gene-editing trial

CNN  

Story highlights Chinese scientists to conduct world's first gene-edited trial in humans Team hopes edited-genes could be used to fight lung cancer Hong Kong CNN — Chinese scientists will become the first in the world to inject people with cells modified using gene-editing technology in a groundbreaking clinical trial next month. A team led by Lu You, an oncologist at …

HIV cure a step closer after scientists remove virus's DNA from living tissue
8 years, 10 months ago

HIV cure a step closer after scientists remove virus's DNA from living tissue

The Independent  

Sign up for our free Health Check email to receive exclusive analysis on the week in health Get our free Health Check email Get our free Health Check email SIGN UP I would like to be emailed about offers, events and updates from The Independent. Read our privacy policy Scientists have managed to remove DNA of the HIV virus from …

Chinese doctors experiment with making genetically-modified HIV-proof human embryos
8 years, 11 months ago

Chinese doctors experiment with making genetically-modified HIV-proof human embryos

Daily Mail  

Chinese scientists have been editing human embryos in an attempt to make them resistant to HIV infection. There has only ever been one previously published claim of human embryo genetic editing Chinese scientists have been editing human embryos in an attempt to make them resistant to HIV infection. The Chinese scientists tried to make human embryos resistant to HIV by …

HIV cure now a step closer after scientists make gene editing breakthrough
8 years, 11 months ago

HIV cure now a step closer after scientists make gene editing breakthrough

The Independent  

Sign up for our free Health Check email to receive exclusive analysis on the week in health Get our free Health Check email Get our free Health Check email SIGN UP I would like to be emailed about offers, events and updates from The Independent. Read our privacy policy American scientists have made huge strides towards finding a cure for …

Is the cure for HIV just a few years away?
8 years, 11 months ago

Is the cure for HIV just a few years away?

Daily Mail  

A cure for HIV could be just years away scientists hope, after they succeeded in cutting the virus out of infected cells, eradicating it permanently. 'They demonstrate the effectiveness of our gene editing system in eliminating HIV from the DNA of CD4 T-cells and, by introducing mutations in the viral genome, permanently inactivating its replication. demonstrate the effectiveness of our …

Gene editing: Should we be worried? (Opinion)
9 years, 1 month ago

Gene editing: Should we be worried? (Opinion)

CNN  

Editor’s Note: Robert Klitzman is a professor of psychiatry and director of the Masters of Bioethics Program at Columbia University. Story highlights British researchers last week given OK to use gene editing on human embryos Robert Klitzman: Tampering with nature undoubtedly has perils but also has big potential benefits CNN — Every week, I get unsolicited email ads from airlines, …

Q&A: Why CRISPR-Cas9 is being hailed as the scientific ‘Breakthrough of the Year’
9 years, 3 months ago

Q&A: Why CRISPR-Cas9 is being hailed as the scientific ‘Breakthrough of the Year’

LA Times  

CRISPR is having a moment. Scientists who use this technology say it has made targeting and changing genes in a cell’s DNA easier and more precise than ever before. Paul Knoepfler, a stem cell researcher at UC Davis, describes CRISPR as a molecular Swiss army knife: It’s part genome scanner, part scissors to cut the DNA, and part pencil to …

Crispr-Cas9: Revolutionary gene editing technique named scientific breakthrough of the year
9 years, 3 months ago

Crispr-Cas9: Revolutionary gene editing technique named scientific breakthrough of the year

The Independent  

Sign up for our free Health Check email to receive exclusive analysis on the week in health Get our free Health Check email Get our free Health Check email SIGN UP I would like to be emailed about offers, events and updates from The Independent. Read our privacy policy A revolutionary technique for editing the DNA of the human genome …

Gene editing could pave way for pig organ transplants
9 years, 5 months ago

Gene editing could pave way for pig organ transplants

Live Mint  

Chicago: US researchers have used a new gene editing technique to trim away potentially harmful virus genes that have impeded the use of pig organs for transplants in humans. In the latest study led by Dr. George Church, a geneticist from Harvard Medical School, researchers simultaneously snipped away genetic material in 62 specific locations in the pig genome. Church first …

The War Over Genome Editing Just Got a Lot More Interesting
9 years, 6 months ago

The War Over Genome Editing Just Got a Lot More Interesting

Wired  

If you want to drop some real DNA editing knowledge—like, I don’t know, at a party!—here’s a tip. Today, gene-editing scientists dropped some curious news: They’ve found a CRISPR system involving a different protein that also edits human DNA, and, in some cases, it may work even better than Cas9. “There are definitely many more defense systems out there, and …

Will DNA-editing CRISPR change medicine?
9 years, 7 months ago

Will DNA-editing CRISPR change medicine?

CNN  

Story highlights CRISPR technique for editing genes may eventually be used to single out and destroy genes that cause disease Editas, already developing CRISPR-based therapies, recently received a large investment to expand its research CNN — A popular new gene therapy technology could help treat cataracts, liver disease, muscular dystrophy and other conditions. Editas Medicine, a biotech company in Cambridge, …

Crispr: The science behind a 'game-changing' gene-editing technique
9 years, 8 months ago

Crispr: The science behind a 'game-changing' gene-editing technique

The Independent  

Sign up for our free Health Check email to receive exclusive analysis on the week in health Get our free Health Check email Get our free Health Check email SIGN UP I would like to be emailed about offers, events and updates from The Independent. Read our privacy policy It has been less than five years since it was first …

Editing the Softwareof Life, for Fameand Fortune
9 years, 9 months ago

Editing the Softwareof Life, for Fameand Fortune

Wired  

Jennifer Doudna#### One lab spawned two startups hoping to dominate the booming world of genome editing. Doudna envisioned a world in which any scientist working with living organisms might use these proteins to make controlled cuts in a genome to modify its function. Along with her collaborators and students, Doudna demonstrated that a protein called cas9 could be engineered to …

America Needs to Figure Out the Ethics of Gene Editing Now
9 years, 11 months ago

America Needs to Figure Out the Ethics of Gene Editing Now

Wired  

In an international first, researchers in China have reported doing experiments that involve editing the genome of a human embryo. In the research, published a week ago in the journal Protein and Cell, the scientists used a powerful new DNA-editing method called CRISPR/Cas9 to replace the genes that cause a potentially deadly blood disorder. Within the past few months, several …

A CRISPR Way To Fix Faulty Genes
10 years, 9 months ago

A CRISPR Way To Fix Faulty Genes

NPR  

A CRISPR Way To Fix Faulty Genes Enlarge this image toggle caption Illustration courtesy of Jennifer Doudna/UC Berkeley Illustration courtesy of Jennifer Doudna/UC Berkeley Scientists from many areas of biology are flocking to a technique that allows them to work inside cells, making changes in specific genes far faster — and for far less money — than ever before. "It's …

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