New study uncovers new details of SARS-CoV-2 interactions with human cells
3 years, 9 months ago

New study uncovers new details of SARS-CoV-2 interactions with human cells

Hindustan Times  

A new study published in Biophysical Society, introduces new molecular models to show what parts of SARS-CoV-2 are critical for that interaction, revealing new potential drug targets for the infection. In order to infect cells, SARS-CoV-2, the virus that causes Covid-19, needs to insert itself into the membrane of human cells. A small region of the SARS-CoV-2 outer spike protein called the "fusion peptide," inserts itself into the human cell membrane to begin the fusion process. Without knowing the three-dimensional interactions between the SARS-CoV-2 fusion peptide and the cell membrane, it is not possible to design drugs that specifically disrupt that interaction. Using computer simulations, the team merged what is known about the SARS-CoV-2 fusion peptide with the established three-dimensional structures and behaviors of other coronavirus fusion peptides and simulated its interaction with a model human cell membrane.

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Scientists develop molecule that blocks covid-19 infection
3 years ago

Scientists develop molecule that blocks covid-19 infection

Live Mint  

Scientists have developed a new molecule that attaches to the surface of the SARS-CoV-2 virus and prevents it from entering human cells and spreading the COVID-19 infection. The researchers at Aarhus University in Denmark noted that the molecule is cheaper and easier to manufacture than the antibodies currently used to treat COVID-19, and to detect viral infection using rapid antigen …

Large-scale drug analysis reveals potential new COVID-19 antivirals
3 years, 5 months ago

Large-scale drug analysis reveals potential new COVID-19 antivirals

Deccan Chronicle  

London: Researchers at the Francis Crick Institute and University of Dundee have screened thousands of drug and chemical molecules and identified a range of potential antivirals that could be developed into new treatments for COVID-19 or in preparation for future coronavirus outbreaks. In a series of seven papers, published in the Biochemical Journal, the scientists identified 15 molecules that inhibit …

Exposure to SARS-CoV-2 Spike Protein Alone Enough to Damage Lungs: Study
3 years, 7 months ago

Exposure to SARS-CoV-2 Spike Protein Alone Enough to Damage Lungs: Study

News 18  

A team of researchers in the US have found that exposure to the SARS-CoV-2 spike protein alone was enough to induce Covid-19-like symptoms, including severe inflammation of the lungs. The researchers from Old Dominion University, Virginia, US, developed a genetically modified mouse and injected it with a segment of the spike protein and analysed their response 72 hours later. The …

Know what makes SARS-COV-2 a threat
3 years, 8 months ago

Know what makes SARS-COV-2 a threat

India TV News  

Coronavirus pandemic has brought about a sense of fear and anxiety around the globe. Research showed that SARS-CoV-2 uses a receptor called ACE2 to gain entry into human cells, aided by an enzyme called TMPRSS2. The study, led by Jose Ordovas-Montanes, doctoral student at the Boston Children's Hospital, in the US, found that one of the body's main defences against …

Scientists reveal how coronavirus could be hijacking human cells
3 years, 10 months ago

Scientists reveal how coronavirus could be hijacking human cells

Live Mint  

Scientists, including one of Indian-origin, have identified parts of human proteins which the novel coronavirus could be using to hijack host cell processes, an advance that may lead to the development of new drugs for treating covid-19. The researchers, including Manjeet Kumar from the European Molecular Biology Laboratory in HeidelbGermany, analysed the chain of amino acid molecules that makes up …

Not Just Your Lungs, Coronavirus Can Cause Brain Tissue Damage and Infect Neurons
3 years, 11 months ago

Not Just Your Lungs, Coronavirus Can Cause Brain Tissue Damage and Infect Neurons

News 18  

Researchers have discovered that SARS-CoV-2 can directly infect the central nervous system and have begun to unravel some of the virus’s effects on brain cells. The study, that used both mouse and human brain tissue, indicates that SARS-CoV-2 can affect many other organs in the body, including, in some patients, the central nervous system, where infection is associated with a …

Covid-19: Scientists develop bio decoys to lure and kill coronavirus
4 years, 5 months ago

Covid-19: Scientists develop bio decoys to lure and kill coronavirus

India Today  

Coronavirus has proven itself to be a smart beast. The discovery was made in a laboratory setting, where researchers used decoy polymers to see if these harmless artificial particles lure novel coronavirus into a trap or not. This is a decoy technique as it works by creating microscopic bio-friendly polymers, which are coated with cells from living lung tissue or …

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