Explained | 2022 Nobel Prize winners’ research on click and bioorthogonal chemistry
The story so far: The 2022 Nobel Prize in Chemistry has been awarded to chemists Carolyn R. Bertozzi and K. Barry Sharpless from the U.S., and Morten Meldal from Denmark, for their work in the field of click chemistry and bioorthogonal chemistry. Dr. Sharpless was the first scientist to work on what is today called click chemistry – a branch of science that explores the assembly of molecules. Soon after, Dr. Meldal and Dr. Sharpless – independently of each other – presented the copper-catalysed azide-alkyne cycloaddition, a reaction that is now widely used in fields like medicinal chemistry. The CuAAC reaction is an improved form of the azide-alkyne Huisgen cycloaddition, which was once called the “cream of the crop” among click reactions by Dr. Sharpless and other authors in a research paper published in 2001. Dr. Sharpless described this reaction as an “ideal” click chemistry reaction.
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