A single mutation could make bird flu much worse, study finds
2 weeks, 3 days ago

A single mutation could make bird flu much worse, study finds

Salon  

As the number of human bird flu cases continues to rise and more dairy farms across the country report outbreaks, scientists are increasingly concerned that the H5N1 virus will mutate to better infect people. In the lab, the authors of the study found that a single mutation in the primary protein, hemagglutinin could give it the ability to cling onto receptors found in the human respiratory tract, potentially increasing the severity of disease or transmissibility. While most human bird flu cases have been mild, a Canadian teen infected with the virus last month was hospitalized in critical condition after developing a severe lung infection. While it is unclear whether this mutation happened within the individual or if the teen was infected with an already mutated strain of the virus, this mutation was the very same one that the authors of this study found could make the virus more infectious, although it was missing some of the protein changes found in the Canadian teen's sequencing.

History of this topic

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