
High-scoring Bills return from their bye week to host inconsistent 49ers, losers of their past 2
Associated PressSan Francisco at Buffalo Sunday, 8:20 p.m. EST, NBC BetMGM NFL odds: Bills by 7. The 49ers are hopeful he can play Sunday.. Niners DE Nick Bosa and LT Trent Williams also could return this week after sitting out Sunday.. LG Aaron Banks, DT Jordan Elliott and WR Jacob Cowing all began the week in the concussion protocol for San Francisco.. Niners RG Dominick Puni and CB Deommodore Lenoir also are dealing with injuries.. Bills TE Dalton Kincaid continues sitting out practice with a knee injury and is in jeopardy of missing his second game.. The Niners have scored only three offensive TDs from outside the red zone this season, tied for the second fewest in the NFL.. San Francisco ranks 10th worst in the NFL with 3.85 yards per carry in three games since McCaffrey returned after ranking fourth with 5.13 in the first eight weeks.. The 44 yards rushing last week for the 49ers were their third fewest under Shanahan.. TE George Kittle had his 509th catch last week, moving into third place in San Francisco history.. Kittle leads the NFL with eight TD catches in the red zone, which is tied with Vernon Davis for the most in a season for a Niners player since at least 2000.. He’s 43-27 overall when committing a turnover.. Allen has rushed for five TDs this season, increasing his total to 58 to rank second on the team list behind only Hall of Famer Thurman Thomas.. With two TDs rushing in a 30-21 win over Kansas City two weeks ago, RB James Cook became Buffalo’s first player to rush for 10 scores since LeSean McCoy had 13 in 2016.. Buffalo’s defense has forced at least one takeaway in each outing this season.
History of this topic

49ers head home early following a trying season that started with Super Bowl hopes
Associated Press
Bills seek to lock up AFC’s No. 2 seed in closing home schedule against the Jets
Associated Press
Lions try to close in on NFC’s top seed when they visit the eliminated 49ers
Associated Press
Mistake-filled defeat to Dolphins sums up a lost season for the 49ers
Associated Press
Dolphins keep playoff hopes alive with 29-17 win over 49ers, who were eliminated Sunday afternoon
Associated Press
Dolphins and 49ers will both try to bounce back from disappointing losses when they meet Sunday
Associated Press
Rams vs. San Francisco 49ers: How to watch, prediction and betting odds
LA Times
Rams visit the 49ers seeking their first season sweep in the series since 2018
Associated Press
The 49ers’ playoff hopes are still teetering even after get-right game against the Bears
Associated Press
49ers beat the Bears 38-13 to spoil Thomas Brown’s coaching debut
Associated Press
Rams vs. Buffalo Bills: How to watch, prediction and betting odds
LA Times
Bears bring an interim coach into their meeting against the struggling 49ers
Associated Press
49ers have tough matchup and snow in forecast vs. Bills as they try to turn season around
Associated Press
49ers attempt to bounce back and boost their postseason chances as they visit Green Bay
Associated Press
49ers seek their 7th straight win against the Seahawks
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Bucs host 49ers with both teams aiming to build momentum for strong second-half push
Associated Press
49ers Aim to Continue Second-Half Domination After Slumping Start
Associated Press
Six 49ers predictions at NFL midseason: George Kittle will lead offense; watch out for Rams
New York Times
49ers Head into Bye on a Winning Note, With Hope for McCaffrey's Return
Associated Press
Cowboys and 49ers Battle for Rebounds in Crucial Game
Associated Press
49ers sack Jacoby Brissett six times in 30-13 win over Patriots: Key takeaways
New York Times
49ers look to bounce back from consecutive road losses when they host the Patriots
Associated Press
San Francisco 49ers are dealt ANOTHER big injury blow as star player misses practice before Rams game with hamstring problem
Daily Mail
Rams, 49ers both missing key players going into NFC West matchup
Associated Press
The 49ers call their latest loss at Minnesota a ‘wake-up call’
Associated Press
49ers need Brandon Aiyuk-Brock Purdy connection to shake off rust for offense to return to form
New York Times
Aaron Rodgers and the Jets provide a good early test for the new-look 49ers defense
Associated Press
Aaron Rodgers makes his return when the Jets open the season at the 49ers
Associated Press
The Packers visit the 49ers for record-setting 10th playoff matchup
Associated Press
49ers minutia minute: More injuries along the D-line; Jake Moody is PAT king
New York Times
The 49ers get ‘payback’ against the Eagles with dominant win that makes them Super Bowl favorites
Associated Press
NFL Power Rankings Week 14: 49ers make a statement, plus worst-case scenarios
New York Times
NFL Week 12 takeaways: Are Bills’ playoff hopes over after OT loss to Eagles?
New York Times
With Rodgers out and Allen struggling, Jets and Bills don’t carry as much buzz into rematch
Associated Press
San Francisco 49ers return to winning ways against Jacksonville Jaguars
The Independent
The 49ers struggle to come from behind during 3-game losing streak
Associated Press
The 49ers lose their 3rd straight game in mistake-filled 31-17 loss to the Bengals
Associated Press
The 49ers need to find their pass rush after back-to-back losses
Associated Press
NFL: Cleveland Browns end San Francisco 49ers winning streak
The Independent
What we learned in NFL Week 6: Unbeaten no more as 49ers, Eagles upset by backup QBs
New York Times
Giants travel to face a Bills team seeking to rebound in prime-time matchup
Associated Press
What we learned in NFL Week 4: Contending Bills, slumping Steelers and a rookie QB shines
New York Times
Christian McCaffrey and the 49ers win 13th straight in the regular season, beat the Giants 30-12
Associated Press
49ers defeat Giants on TNF: How Brock Purdy, San Francisco defense guided dominant win
New York Times
49ers minutia minute: Nick Bosa logs a lot of snaps but says it’s only ‘up’ from here
New York Times
New York Jets overcome Aaron Rodgers’ early exit to defeat Buffalo Bills
The Independent
San Francisco, Pittsburgh meet in Week 1 with second-year QBs Purdy, Pickett in the spotlight
Associated Press
Purdy, 49ers beat Cowboys 19-12, advance to NFC title game
Associated Press
49ers advance to NFC Championship Game: How San Francisco’s defense limited Cowboys
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