High-scoring Bills return from their bye week to host inconsistent 49ers, losers of their past 2
Associated PressSan Francisco at Buffalo Sunday, 8:20 p.m. EST, NBC BetMGM NFL odds: Bills by 7. The 49ers are hopeful he can play Sunday.. Niners DE Nick Bosa and LT Trent Williams also could return this week after sitting out Sunday.. LG Aaron Banks, DT Jordan Elliott and WR Jacob Cowing all began the week in the concussion protocol for San Francisco.. Niners RG Dominick Puni and CB Deommodore Lenoir also are dealing with injuries.. Bills TE Dalton Kincaid continues sitting out practice with a knee injury and is in jeopardy of missing his second game.. The Niners have scored only three offensive TDs from outside the red zone this season, tied for the second fewest in the NFL.. San Francisco ranks 10th worst in the NFL with 3.85 yards per carry in three games since McCaffrey returned after ranking fourth with 5.13 in the first eight weeks.. The 44 yards rushing last week for the 49ers were their third fewest under Shanahan.. TE George Kittle had his 509th catch last week, moving into third place in San Francisco history.. Kittle leads the NFL with eight TD catches in the red zone, which is tied with Vernon Davis for the most in a season for a Niners player since at least 2000.. He’s 43-27 overall when committing a turnover.. Allen has rushed for five TDs this season, increasing his total to 58 to rank second on the team list behind only Hall of Famer Thurman Thomas.. With two TDs rushing in a 30-21 win over Kansas City two weeks ago, RB James Cook became Buffalo’s first player to rush for 10 scores since LeSean McCoy had 13 in 2016.. Buffalo’s defense has forced at least one takeaway in each outing this season.