Staying prepared: On scaling up the pace of COVID-19 genome sequencing
The HinduThree years after strict enforcement of its Zero-COVID strategy, China abandoned it abruptly, leading to a jump in cases each day — an estimated 250 million people were infected in 20 days in December, according to the media, overwhelming hospitals and crematoria. Though this variant was found in many countries, including India, months ago, there is fear that the uncontrolled spread of the virus in China may result in newer variants with an even higher transmissibility. For instance, the BF.7 sub-lineage with three additional immune escape mutations already seen in other variants has been found in some people arriving from China; these mutations may increase transmissibility further but will not increase disease severity. With over 90% of the adult population already fully vaccinated by July this year, over one-fourth of adults also boosted, and a large percentage of the population also naturally infected, the chances of India witnessing large-scale deaths as seen during the second wave last year from existing variants are slim. In fact, given that a large percentage of the population enjoys hybrid immunity from vaccination and natural infection leading to all Omicron sub-lineages causing only a mild disease, the focus in India should not be on daily new infections but only on any increase in hospitalisations, particularly ICU admissions.