Why eating cannabis edibles feels so different from smoking weed, according to experts
2 years ago

Why eating cannabis edibles feels so different from smoking weed, according to experts

Salon  

Ask anyone who's experimented with ingesting cannabis edibles, and you're apt to hear at least one uncomfortable story involving them. The reason is that eating cannabis produces metabolites that are technically a different drug from THC entirely. "Oral ingestion of cannabis, such as THC and CBD, results in significant first-pass effect, which means that the cannabinoid compounds are circulated to the liver where they are metabolized or broken down into compounds called metabolites," Dr. Bonni Goldstein, author of the book "Cannabis is Medicine," told Salon. Some people have different variants of that CYP2C9, so it actually makes it less effective at metabolizing and effectively getting the THC out," Kyle Boyar, a cannabis scientist based in San Diego who has been studying the plant's chemistry for over a decade, told Salon. "As a cannabis clinician, I have been advising my patients to avoid these synthetic products and only to use home-grown cannabis or tested cannabis products from state-licensed dispensaries," Goldstein added.

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