Endothelial cells could be targeted to restore lung function in COVID-19 patients, suggests study
4 years ago

Endothelial cells could be targeted to restore lung function in COVID-19 patients, suggests study

Firstpost  

The study authors also said that drugs targeting endothelial activation should be used to control inflammation and coagulopathy associated with COVID-19 COVID-19 is primarily a respiratory disease that spreads through droplets. Now, a group of researchers at the Stony Brook University, US, state that endothelial cells don’t have ACE2 receptors and hence SARS-CoV-2 does not infect these cells directly. However, since endothelial damage is seen in COVID-19 patients, the authors suggest that the virus is indirectly affecting endothelial cells. Indirect infection of endothelial cells For the study, the researchers examined SARS-CoV-2 infection in the endothelial cells obtained from the lungs, kidneys, heart, brain and umbilical veins. Targeting the endothelial cells Because the endothelial cells are not actually infected by SARS-CoV-2, drug therapies against the infection would be useless in the treatment of endothelial inflammation in coronavirus patients.

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History of this topic

Severe Covid-19 lung infection may harm the heart
9 months ago

Severe Covid-19 lung infection may harm the heart

India Today  

SARS-CoV-2, the virus responsible for Covid-19, can harm the heart even if it doesn't directly infect heart tissue, according to a recent study. Previous research has shown that Covid-19 increases the risk of heart issues like heart attacks and strokes, and more than half of Covid-19 patients experience some level of heart inflammation or damage. The researchers focused on immune …

SARS-CoV-2 can damage heart blood vessels without infecting them: Study
2 years, 10 months ago

SARS-CoV-2 can damage heart blood vessels without infecting them: Study

India Today  

The SARS-CoV-2 virus may contribute to the damage of small blood vessels in the heart as seen in severely-ill Covid-19 patients, without infecting them, a study shows. A multidisciplinary research team led by the University of Bristol, UK, analysed how SARS-CoV-2 interacts with heart cells causing the myocardial damage seen in Covid-19 patients. The team led by Professor Paolo Madeddu …

SARS-CoV-2 can damage heart blood vessels without infecting them: Study
2 years, 10 months ago

SARS-CoV-2 can damage heart blood vessels without infecting them: Study

Deccan Chronicle  

London: The SARS-CoV-2 virus may contribute to the damage of small blood vessels in the heart as seen in severely-ill COVID-19 patients, without infecting them, a study shows. A multidisciplinary research team led by the University of Bristol, UK, analysed how SARS-CoV-2 interacts with heart cells causing the myocardial damage seen in COVID-19 patients. The team led by Professor Paolo …

Drug that blocks multiple coronavirus variants in mice identified
3 years, 6 months ago

Drug that blocks multiple coronavirus variants in mice identified

The Hindu  

Scientists have identified a new drug which is highly effective in preventing severe COVID-19 in mice infected with SARS-CoV-2, and could also treat other respiratory coronaviruses. The findings, published in the journal Science Immunology, suggest that the drug diABZI activates the body's innate immune response, the first line of defence against invading pathogens. "This paper is the first to show …

Trinity College research finds why COVID 19 is to hard to treat
3 years, 7 months ago

Trinity College research finds why COVID 19 is to hard to treat

India TV News  

Researchers at the Trinity College Dublin showed that a comprehensive review into what we know about Covid 19 and the way it functions suggests that the virus has a unique infectious profile, which explains why it can be so hard to treat and why some people experience a long struggle with the virus, and even after the virus is technically …

Covid's spike protein plays key role in illness: Study
3 years, 7 months ago

Covid's spike protein plays key role in illness: Study

India TV News  

SARS-CoV-2's distinctive "spike" proteins have been known to infect its host by latching on to healthy cells, but scientists have, in a new study, showed that they also play a key role in the disease. The paper, published in the journal Circulation Research, showed conclusively that Covid-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks …

Exposure to SARS-CoV-2 Spike Protein Alone Enough to Damage Lungs: Study
3 years, 7 months ago

Exposure to SARS-CoV-2 Spike Protein Alone Enough to Damage Lungs: Study

News 18  

A team of researchers in the US have found that exposure to the SARS-CoV-2 spike protein alone was enough to induce Covid-19-like symptoms, including severe inflammation of the lungs. The researchers from Old Dominion University, Virginia, US, developed a genetically modified mouse and injected it with a segment of the spike protein and analysed their response 72 hours later. The …

Know what makes SARS-COV-2 a threat
3 years, 8 months ago

Know what makes SARS-COV-2 a threat

India TV News  

Coronavirus pandemic has brought about a sense of fear and anxiety around the globe. Research showed that SARS-CoV-2 uses a receptor called ACE2 to gain entry into human cells, aided by an enzyme called TMPRSS2. The study, led by Jose Ordovas-Montanes, doctoral student at the Boston Children's Hospital, in the US, found that one of the body's main defences against …

Scientists reveal how coronavirus could be hijacking human cells
3 years, 10 months ago

Scientists reveal how coronavirus could be hijacking human cells

Live Mint  

Scientists, including one of Indian-origin, have identified parts of human proteins which the novel coronavirus could be using to hijack host cell processes, an advance that may lead to the development of new drugs for treating covid-19. The researchers, including Manjeet Kumar from the European Molecular Biology Laboratory in HeidelbGermany, analysed the chain of amino acid molecules that makes up …

Not Just Your Lungs, Coronavirus Can Cause Brain Tissue Damage and Infect Neurons
3 years, 11 months ago

Not Just Your Lungs, Coronavirus Can Cause Brain Tissue Damage and Infect Neurons

News 18  

Researchers have discovered that SARS-CoV-2 can directly infect the central nervous system and have begun to unravel some of the virus’s effects on brain cells. The study, that used both mouse and human brain tissue, indicates that SARS-CoV-2 can affect many other organs in the body, including, in some patients, the central nervous system, where infection is associated with a …

Coronavirus | N501Y mutation in SARS-CoV-2 virus causes increased infectivity in mice: researchers
4 years ago

Coronavirus | N501Y mutation in SARS-CoV-2 virus causes increased infectivity in mice: researchers

The Hindu  

In a preliminary report posted on December 19, Dr. Andrew Rambaut from the University of Edinburgh and others from the COVID-19 Genomics UK Consortium say that the new variant has been spreading “rapidly” over the last four weeks. Though no studies have so far been done in humans to assess if the new variant increases the severity of COVID-19 disease, …

How Covid-19 hijacks and damages lung cells decoded, say scientists
4 years ago

How Covid-19 hijacks and damages lung cells decoded, say scientists

India Today  

The chain of molecular responses of human lung cells to infection with the novel coronavirus have been decoded, say scientists. Based on the analysis, the scientists from Boston University School of Medicine in the US, identified proteins and pathways of molecules in lung cells whose levels change upon infection by the SARS-CoV-2 virus. However, the scientists discovered that SARS-CoV-2 throws …

Scientists Map Body-wide Production of Protein with 'Important Role' in Covid-19
4 years, 4 months ago

Scientists Map Body-wide Production of Protein with 'Important Role' in Covid-19

News 18  

Scientists have analysed the presence throughout the human body of a protein which the novel coronavirus uses to enter host cells, and have found that it is produced only at “very low levels, if at all,” in the respiratory system, an advance which highlights the need for further studies to reassess the biological mechanisms responsible for COVID-19. “Here, in contrast …

Coronavirus affects the blood vessels as well as the lungs. Understanding this may be key to treating it
4 years, 5 months ago

Coronavirus affects the blood vessels as well as the lungs. Understanding this may be key to treating it

ABC  

In the global fight against this coronavirus, researchers are looking at how existing medications used to reduce risk of heart disease, including statins and blood thinners, can help to treat COVID-19. "When it first came on the scene, clinically it was affecting the lungs," says Mathew Vadas, executive director of the Centenary Institute, who works on understanding blood vessels. The …

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