Scientists Identify How 'Misfiring' of Immune System is Linked to Averse Covid-19 Conditions
4 years, 4 months ago

Scientists Identify How 'Misfiring' of Immune System is Linked to Averse Covid-19 Conditions

News 18  

Scientists have found how misfiring of the immune system in some patients infected with the novel coronavirus can lead to severe consequences of COVID-19, an advance which may help identify those at high risk of dying from the disease, and suggest drugs to treat them. The study, published in the journal Nature, found that all patients shared a common COVID-19 "signature" in immune system activity early in the course of disease. According to the scientists, patients who went on to develop severe cases of the disease showed no decrease in the levels of the virus particles in their body, or immune system reaction. While earlier studies have identified that the immune system unleashed a massive and damaging "cytokine storm" in severe cases of COVID-19, the scientists said the specific elements of this response were unknown. The current study found that one risk factor was the presence of an immune system molecule called alpha interferon -- a cytokine mobilised to combat viral pathogens such as the flu virus.

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History of this topic

Post-COVID-19 conditions change a person's immunological response: Study
1 year, 7 months ago

Post-COVID-19 conditions change a person's immunological response: Study

Hindustan Times  

A recent study from Cedars-Sinai's Smidt Heart Institute reveals that extended COVID-19 may be caused by a dysfunction of the immune system. The study, published in BMC Infectious Diseases, found that after people with long COVID-19 received the COVID-19 vaccine, they produced antibodies against the virus that causes COVID-19 for months longer than expected. To study the immune response of …

Covid19 triggers massive inflammation? Here's what the experts have to say
2 years, 8 months ago

Covid19 triggers massive inflammation? Here's what the experts have to say

India TV News  

US researchers have identified the reason why Covid-19 causes severe inflammation in some people, leading to acute respiratory distress and multi-organ damage. They found that SARS-CoV-2 can infect monocytes - immune cells in the blood that act as "sentinels" or early responders to infection - as well as macrophages, similar immune cells in the lungs. "In the infected patients, about …

People infected with Covid-19 at increased risk of developing heart conditions up to a year later, says study
2 years, 10 months ago

People infected with Covid-19 at increased risk of developing heart conditions up to a year later, says study

India Today  

People who have had Covid-19 are at increased risk of developing cardiovascular complications within the first month to a year after infection, according to a study conducted in the US. "For people who were clearly at risk for a heart condition before becoming infected with SARS-CoV-2, the findings suggest that Covid-19 may amplify the risk," said Al-Aly. Heart disease, including …

How Immune System Reacts to New Covid-19 Variants, Experts Find
3 years, 5 months ago

How Immune System Reacts to New Covid-19 Variants, Experts Find

News 18  

The body’s natural immune response following Covid infection is sustained for up to seven months, but these antibodies are not sufficient against contemporary variants of the virus, finds a study suggesting the importance of vaccines against the infectious disease. The study, published in the PLOS Medicine, also stressed on the need to invest in new vaccine designs to keep pace …

Explained: Why Are Some People More Resilient to Covid-19?
3 years, 5 months ago

Explained: Why Are Some People More Resilient to Covid-19?

News 18  

Many people experienced serious Covid-19 infection leading to hospitalisation and even death, while some people escaped with milder symptoms. The study, published in the journal Science Immunology, showed that killer T-cells taken from the sickest Covid-19 patients exhibit fewer signs of having had previous run-ins with common-cold-causing coronaviruses. For the study, the team analysed blood samples taken from healthy donors …

Indian-origin scientist spots genes that fight Covid-19 infection
3 years, 8 months ago

Indian-origin scientist spots genes that fight Covid-19 infection

India TV News  

A team of US scientists, led by an Indian-origin researcher, has identified a set of human genes that fight SARS-CoV-2 infection, the virus that causes Covid-19. Knowing which genes help control viral infection can greatly assist researchers' understanding of factors that affect disease severity and also suggest possible therapeutic options. "We found that 65 ISGs controlled SARS-CoV-2 infection, including some …

COVID-19 is especially harsh on elderly people, and researchers think they know why
3 years, 8 months ago

COVID-19 is especially harsh on elderly people, and researchers think they know why

ABC  

Australian researchers have been investigating why elderly people respond so poorly to COVID-19, and theorise that it's linked to their repeated exposure to other seasonal coronaviruses. Key points: The research hypothesised that children saw SARS-CoV-2 as a new virus But older adults saw it as typical, seasonal coronavirus It found children's immune systems could activate surrounding white blood cells to …

Inhalation of Immune System Protein May Help Hospitalised Covid-19 Patients Recover
4 years, 1 month ago

Inhalation of Immune System Protein May Help Hospitalised Covid-19 Patients Recover

News 18  

Hospitalised COVID-19 patients who received an inhaled form of an immune system protein were less likely to develop severe symptoms, according to a new study which may lead to a new treatment strategy against the disease. In the new study a formulation of interferon beta called SNG001 was directly delivered to the lungs via inhalation and its safety and efficacy …

‘Breakthrough finding’ offers clues about why certain COVID-19 patients die
4 years, 1 month ago

‘Breakthrough finding’ offers clues about why certain COVID-19 patients die

LA Times  

What makes some COVID-19 patients so much sicker than others? In an international study published last month in the journal Science, 10% of nearly 1,000 COVID-19 patients who developed life-threatening pneumonia had antibodies that disable key immune system proteins called interferons. “This is one of the most important things we’ve learned about the immune system since the start of the …

T-cell study adds to debate over duration of covid-19 immunity
4 years, 1 month ago

T-cell study adds to debate over duration of covid-19 immunity

Live Mint  

A small UK study has found that "cellular immunity" to the pandemic SARS-CoV-2 virus is present after six months in people who had mild or asymptomatic COVID-19 infections - suggesting they might have some level of protection for at least that time. Scientists presenting the findings, from 100 non-hospitalised COVID-19 patients in Britain, said they were "reassuring" but did not …

Covid-19: Underlying Health Condition Poses Higher Risk of Death
4 years, 2 months ago

Covid-19: Underlying Health Condition Poses Higher Risk of Death

News 18  

An analysis from multiple studies have found that people with certain underlying medical conditions have a higher risk for severe illness on Covid-19 infected patients. Patients with an underlying medical condition like cardiovascular disease, asthma, diabetes, congestive heart failure, hypertension, chronic kidney disease, stroke, liver disease, HIV/AIDS and cancer can escalate the risk of dying from Covid-19. Patients with cardiovascular …

Majority of COVID-19 cases developed symptoms, only 20 pc asymptomatic: Study
4 years, 3 months ago

Majority of COVID-19 cases developed symptoms, only 20 pc asymptomatic: Study

India TV News  

Most people who are infected by the SARS-CoV-2 virus, that causes COVID-19, are not asymptomatic throughout the course of infection, a review of studies carried early in the pandemic suggests. Some people with the virus may experience severe infections resulting in viral pneumonia, respiratory distress syndrome, and death, while others remain completely asymptomatic or develop mild, nonspecific symptoms. The researchers …

There are now three known cases of patients contracting COVID-19 twice
4 years, 3 months ago

There are now three known cases of patients contracting COVID-19 twice

Salon  

There are now three known cases around the world of patients who had been previously afflicted by COVID-19 who contracted the virus a second time, months after clearing the first infection. "Our understanding of the interaction of the SARS-CoV-2 virus with the human immune system is at a very early stage," Medford explained by email. Medford said the next step …

Scientists decode immune system changes in children with rare COVID-19 related syndrome
4 years, 4 months ago

Scientists decode immune system changes in children with rare COVID-19 related syndrome

India TV News  

Scientists have uncovered how the immune system is altered in a rare COVID-19 related illness in children which can cause severe inflammation and heart damage, findings that may lead to better treatment for some of the youngest patients infected with the novel coronavirus. According to the researchers, including those from King's College London in the UK, the rare disease, referred …

Scientists decode how immune system malfunctions in severe COVID-19 cases
4 years, 4 months ago

Scientists decode how immune system malfunctions in severe COVID-19 cases

India TV News  

Contrary to earlier studies, scientists have found that severe COVID-19 does not solely result in a hyperactive immune system, but instead the body's defense response is caught in a continuous loop of activation and inhibition, an advance that may help develop better therapeutics to combat the deadly disease. "In combination with the observation of important proteins on the surface of …

Biological patterns underlying some of the most severe COVID-19 cases revealed by scientists
4 years, 4 months ago

Biological patterns underlying some of the most severe COVID-19 cases revealed by scientists

Firstpost  

Treating severe COVID-19 might require an immunological reset, with drugs that could, in theory, restore the balance in the body. “It’s normal to develop inflammation during a viral infection,” said Catherine Blish, a viral immunologist at Stanford University. “The problem comes when you can’t resolve it.” This sustained signaling may result in part from the body’s inability to keep the …

COVID-19 antibodies fade rapidly in mild cases, raise risk of lost immunity: Report
4 years, 5 months ago

COVID-19 antibodies fade rapidly in mild cases, raise risk of lost immunity: Report

India TV News  

In people with mild cases of COVID-19, antibodies against the novel coronavirus may drop sharply over the first three months after infection, according to a research which says the levels may decrease by roughly half every 73 days. According to the scientists, the current research, published in the New England Journal of Medicine, is the first to carefully estimate the …

COVID-19 immunity: Studies show antibodies against novel coronavirus may last only for two-six months
4 years, 6 months ago

COVID-19 immunity: Studies show antibodies against novel coronavirus may last only for two-six months

Firstpost  

Nearly 8.5 million people have been reported to be COVID-19 positive in the world and over 456,000 have died of the disease within the past six months. Nearly 8.5 million people have been reported to be COVID-19 positive in the world and over 4,56,000 have died of the disease within the past six months. Asymptomatic people show a decline in …

Covid-19: Here’s why Coronavirus disease affect people differently
4 years, 6 months ago

Covid-19: Here’s why Coronavirus disease affect people differently

Hindustan Times  

The coronavirus can be deadly for some people or no big deal for others. The issue of disease variability “is the most critical question about COVID-19,” The Washington Post quoted Edward Behrens, chief of the rheumatology division at Children’s Hospital of Philadelphia. Collins further stated in comparison to potential mutations and dosages, the most critical factor is the person getting …

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