What you need to know about scientists fixing mutant genes
7 years, 7 months ago

What you need to know about scientists fixing mutant genes

ABC  

Gene editing is getting fresh attention thanks to a successful lab experiment with human embryos. In laboratory experiments, a team led by Oregon researchers used CRISPR to successfully repair a heart-damaging gene in human embryos, marking a step toward one day being able to prevent inherited diseases from being passed on to the next generation. The biggest everyday use of CRISPR so far is to engineer animals with human-like disorders for basic research, such as learning how genes cause disease or influence development and what therapies might help. But promising research, in labs and animals so far, also suggests gene editing might lead to treatments for diseases such as sickle cell disease, cancer and maybe Huntington's disease, by altering cells and returning them to the body. Beyond medicine Researchers also are using gene editing to hatch malaria-resistant mosquitoes, grow strains of algae that produce biofuels, improve crop growth, even make mushrooms that don't brown as quickly.

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History of this topic

Code breakers: Could gene editing help ready species for a rapidly changing planet?
3 weeks, 4 days ago

Code breakers: Could gene editing help ready species for a rapidly changing planet?

Hindustan Times  

It all began with a simple question: How do bacteria defend themselves against viruses? “Gene editing creates precise changes with a specific aim, which makes it different from breeding technologies of past decades like mutation breeding which created random mutations in hope of finding an occasional beneficial one.” Meanwhile, the carbon footprint of the gene editing process itself is negligible. …

Putting the gene editing tool to use
2 months, 2 weeks ago

Putting the gene editing tool to use

The Hindu  

When you edit a letter or a document, you make specific changes in the words and phrases to make the meaning clearer. Gene editing involves changing the sequence of DNA using specific enzymes which can cut DNA at a precise location, thus permitting the removal, addition, or replacement of genetic information within a gene. He then went ahead, obtained a …

RNA editing is the next frontier in gene therapy – here’s what you need to know
3 months, 3 weeks ago

RNA editing is the next frontier in gene therapy – here’s what you need to know

Raw Story  

The United States Food and Drug Administration has just approved the first-ever clinical trial that uses CRISPR-Cas13 RNA editing. Thanks to recent advances, we now have the tools to directly change someone’s DNA – this has paved the way for gene editing as a type of gene therapy. RNA editing doesn’t permanently change a person’s DNA, but rather alters the …

With CRISPR poised to revolutionise therapy, a pause to consider ethical issues
1 year, 1 month ago

With CRISPR poised to revolutionise therapy, a pause to consider ethical issues

The Hindu  

“We will each write a ghost story”, said Lord Byron; and his proposition was acceded to. With the first gene editing technology securing approval for the treatment of sickle cell anemia and beta-thalassemia, we transcend into a new revolutionary phase. Casgevy and Lyfgenia, the two cell-based gene therapies approved by the Food and Drug Administration for sickle cell anemia treatment …

How can gene editing help cure diseases? | In Focus podcast
1 year, 3 months ago

How can gene editing help cure diseases? | In Focus podcast

The Hindu  

This month, there’s been a lot of excitement in the medical world over the approval given to treatments for diseases that based on genome editing. In 2020, the Nobel Prize for Chemistry was given to two women scientists, Emmanuelle Charpentier and Jennifer Doudna for their discovery of what is essentially a genetic scissors, a tool that allows scientists to cut …

Crispr Wants to Feed the World
2 years, 1 month ago

Crispr Wants to Feed the World

Wired  

Ten years after its discovery, the implications of Crispr genome editing are profound and far-reaching, and we are only getting started. For instance, following on the heels of the initial clinical trial results, the first agricultural applications using Crispr have recently entered the market: A US Food and Drug Administration–approved edit to cattle genes re-creates a slick coat that is …

What is gene editing and how could it be used to develop new food crops?
3 years, 5 months ago

What is gene editing and how could it be used to develop new food crops?

The Independent  

Sign up for our free Health Check email to receive exclusive analysis on the week in health Get our free Health Check email Get our free Health Check email SIGN UP I would like to be emailed about offers, events and updates from The Independent. Read our privacy policy The government has announced plans to relax rules around gene editing, …

CRISPR gene editing can cause unwanted changes in human embryos, study finds
4 years, 4 months ago

CRISPR gene editing can cause unwanted changes in human embryos, study finds

Firstpost  

Instead of addressing genetic mutations, the CRISPR-Cas9 technology appeared to wreak genetic havoc in about half the specimens that the researchers examined A powerful gene-editing tool called CRISPR-Cas9, which this month nabbed the Nobel Prize in Chemistry for two female scientists, can cause serious side effects in the cells of human embryos, prompting them to discard large chunks of their …

Lab tests show risks of using CRISPR gene editing on embryos
4 years, 4 months ago

Lab tests show risks of using CRISPR gene editing on embryos

Associated Press  

A lab experiment aimed at fixing defective DNA in human embryos shows what can go wrong with this type of gene editing and why leading scientists say it’s too unsafe to try. “If our results had been known two years ago, I doubt that anyone would have gone ahead” and tried it on embryos intended for pregnancy, said biologist Dieter …

Crispr: What is genome editing? All you need to know about Nobel-winning controversial technology
4 years, 5 months ago

Crispr: What is genome editing? All you need to know about Nobel-winning controversial technology

India Today  

Two women -- Emmanuelle Charpentier and Jennifer Doudna -- were awarded the 2020 Nobel Prize for chemistry by the Nobel Committee on Wednesday. The duo received the Nobel Prize in chemistry award for developing a method of genome editing, or gene editing, likened to "molecular scissors" that offers the promise of one day curing inherited diseases and even cancer. A …

Scientists claim to have uses CRISPR for the first time to treat a patient who was blind
5 years ago

Scientists claim to have uses CRISPR for the first time to treat a patient who was blind

Firstpost  

They said that it will take up to a month to see if this surgery worked and has restored the patient’s vision. Scientists say they have used the gene-editing tool CRISPR inside someone’s body for the first time, a new frontier for efforts to operate on DNA, the chemical code of life, to treat diseases. “We think it could open …

Scientists Create New, More Powerful Technique To Edit Genes
5 years, 5 months ago

Scientists Create New, More Powerful Technique To Edit Genes

NPR  

Scientists Create New, More Powerful Technique To Edit Genes Scientists have created a new way to edit DNA that appears to make it even easier to precisely and safely re-write genes. "It's proven difficult to use these molecular scissors to make precise DNA changes in most cell types," says David Liu, a biologist at Harvard, MIT and the Broad Institute …

For the first time, researchers use gene editing to cure mice of HIV
5 years, 8 months ago

For the first time, researchers use gene editing to cure mice of HIV

Salon  

For the first time in history, researchers have successfully eliminated HIV from infected mice DNA. In a study published on Tuesday in Nature Communications, researchers reported a potential new way to cure HIV, a disease that affects an estimated 1.1 million people in the United States. Fortunately, life expectancy for those living with AIDS has greatly improved over the last …

CRISPR: The genetic editing tool that holds promise & peril
6 years, 3 months ago

CRISPR: The genetic editing tool that holds promise & peril

Live Mint  

Chinese researcher He Jiankui has claimed that he used CRISPR to produce the world’s first “designer babies”. Jiankui said he used CRISPR—Clustered Regularly Interspaced Short Palindromic Repeats—to alter the genes of a pair of twins while they were embryos to make the babies resistant to HIV, the virus that causes AIDS. In 2017, a US science and medicine advisory group …

Facing Backlash, Chinese Scientist Defends Gene-Editing Research On Babies
6 years, 3 months ago

Facing Backlash, Chinese Scientist Defends Gene-Editing Research On Babies

NPR  

Facing Backlash, Chinese Scientist Defends Gene-Editing Research On Babies Enlarge this image toggle caption Kin Cheung/AP Kin Cheung/AP Updated at 6:15 a.m. Enlarge this image toggle caption Kin Cheung/AP Kin Cheung/AP She spoke after Harvard Medical School Dean George Daley alluded to He's claims as "missteps" that he worried might set back a highly promising field of research. "Just because …

First gene-edited babies are here: Here's a look at the complete experiment
6 years, 3 months ago

First gene-edited babies are here: Here's a look at the complete experiment

India Today  

In a first, genetically edited babies have been welcomed by the world. In an interview to Associated Press, Shenzhen said he altered embryos for seven couples during fertility treatments, with one pregnancy resulting thus far. In all, 16 of 22 embryos were edited, and 11 embryos were used in six implant attempts before the twin pregnancy was achieved, he said …

Editing our genes
6 years, 6 months ago

Editing our genes

The Hindu  

American biochemist Jennifer Doudna, one of the pioneers of the gene editing tool Crispr-Cas9, woke up in a cold sweat after she dreamt of Adolf Hitler. In the book she co-authored, A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution, Doudna recounts the dream, and acknowledges the “truly incredible power” of the technology, “one that could …

HOW DOES CRISPR DNA EDITING WORK?
6 years, 6 months ago

HOW DOES CRISPR DNA EDITING WORK?

Daily Mail  

The CRISPR gene editing technique is being used an increasing amount in health research because it can change the building blocks of the body. Technically called CRISPR-Cas9, the process involves sending new strands of DNA and enzymes into organisms to edit their genes. Cas9 enzymes can then cut strands of DNA, effectively turning off a gene, or remove sections of …

What is Crispr Gene Editing? The Complete WIRED Guide
6 years, 10 months ago

What is Crispr Gene Editing? The Complete WIRED Guide

Wired  

But we won’t get there with the tools we’ve currently got, which is why researchers are now racing to chart the full expanses of the Crispr universe. Each new enzyme will not only advance Crispr’s gene editing powers but also extend its capabilities far beyond DNA manipulation. Because Crispr doesn’t use plant pathogens to manipulate DNA, the USDA has given …

Crispr’d Food, Coming Soon to a Supermarket Near You
6 years, 11 months ago

Crispr’d Food, Coming Soon to a Supermarket Near You

Wired  

For years now, the US Department of Agriculture has been flirting with the latest and greatest DNA manipulation technologies. “Having this consistent position enables smaller companies and academic labs to form this ecosystem of innovation to bring options to consumers,” says Federico Tripodi, CEO of Calyxt, a Minnesota-based gene editing firm. His company has already planted rows and rows of …

CRISPR: offering a new hope for gene editing in plants, animals and humans
6 years, 11 months ago

CRISPR: offering a new hope for gene editing in plants, animals and humans

Live Mint  

Even in times as grim as the current global scenario, a few science stories offer hope and optimism. Although CRISPR-Cas9 is primarily known for its use in treating diseases like AIDS, amyotrophic lateral sclerosis and Huntington’s disease, researchers are now looking at furthering its use to tackle famine, lending a hand in creating antibiotics, and even wiping out an entire …

WHAT IS CRISPR-CAS9?
7 years, 3 months ago

WHAT IS CRISPR-CAS9?

Daily Mail  

The approach has been used previously to edit the HBB gene responsible for a condition called β-thalassaemia. Get ready for genetically engineered 'super chocolate': Scientists use gene editing tools to make cacao trees resistant to disease Gene-editing tool CRISPR-Cas9 could help breed cacao trees that exhibit desirable traits such as enhanced resistance to diseases, a Penn. Revolutionary gene-editing tool CRISPR …

AP Exclusive: US scientists try 1st gene editing in the body
7 years, 4 months ago

AP Exclusive: US scientists try 1st gene editing in the body

Associated Press  

OAKLAND, Calif. — Scientists for the first time have tried editing a gene inside the body in a bold attempt to permanently change a person’s DNA to cure a disease. He met her 15 years ago in a study that tested this enzyme therapy at UCSF Benioff Children’s Hospital Oakland, where the gene editing experiment took place. We’re just learning,” …

New RNA editing tool can eradicate genetic diseases
7 years, 4 months ago

New RNA editing tool can eradicate genetic diseases

Live Mint  

Boston: Scientists have created a new gene editing tool that tweaks the individual RNA ‘letters’ in human cells without making changes to the entire genome, paving the way for therapies that can reverse disease-causing mutations. “The ability to correct disease-causing mutations is one of the primary goals of genome editing,” said Feng Zhang, from MIT. “This new ability to edit …

Gene editing breakthrough allows precise fixes of humans and could destroy thousands of most deadly diseases
7 years, 5 months ago

Gene editing breakthrough allows precise fixes of humans and could destroy thousands of most deadly diseases

The Independent  

Sign up for our free Health Check email to receive exclusive analysis on the week in health Get our free Health Check email Get our free Health Check email SIGN UP I would like to be emailed about offers, events and updates from The Independent. Read our privacy policy A new gene editing breakthrough allows scientists to easily snip out …

New gene-editing technique may lead to treatment for thousands of diseases
7 years, 5 months ago

New gene-editing technique may lead to treatment for thousands of diseases

LA Times  

The CRISPR gene-editing technique is revolutionizing genetics research. In the new study, published Wednesday in the journal Nature, the authors present a second base editor that can convert the base adenine into the base inosine, which acts like guanine. The type of mistake that can be targeted by the new base editor is “by far, the most common kind” in …

Scientists edit gene for blood disease in human embryos
7 years, 5 months ago

Scientists edit gene for blood disease in human embryos

CNN  

Story highlights A complex gene-editing technique was used to correct a mutation in embryos One expert describes the technique as "chemical surgery" CNN — In the future, it might be possible to prevent inherited illnesses by making a change to a single faulty gene. For the first time, scientists used a controversial gene-editing technique called base editing to correct a …

What is genome editing?
7 years, 7 months ago

What is genome editing?

The Hindu  

In a first, researchers from the Oregon Health and Science University along with colleagues in California, China and South Korea repaired a mutation in human embryos by using a gene-editing tool called CRISPR-Cas9. The gene editing tool has two components — a single-guide RNA that contains a sequence that can bind to DNA, and the Cas9 enzyme which acts as …

For first time ever, scientists are able to edit DNA in human embryos through CRISPR technique!
7 years, 7 months ago

For first time ever, scientists are able to edit DNA in human embryos through CRISPR technique!

India TV News  

In a recent breakthrough, US scientists have been able to modify genes of a human embryo to correct a disease-causing mutation. "We have demonstrated the possibility to correct mutations in a human embryo in a safe way and with a certain degree of efficiency," said Juan Carlos Izpisua Belmonte, a professor in Salk's Gene Expression Laboratory and a co-author of …

First embryo gene repair holds promise of wiping inherited diseases out of family's bloodline
7 years, 7 months ago

First embryo gene repair holds promise of wiping inherited diseases out of family's bloodline

ABC  

In a first, researchers have safely repaired a disease-causing gene in human embryos, targeting a heart defect best known for killing young athletes — a big step towards one day preventing a list of inherited diseases. Key points: Embryos cured themselves of a heart-weakening disease and affects about 1 in 500 people Scientists displaying cautious optimism of research in its …

Science Says: Gene editing widely used in range of research
7 years, 7 months ago

Science Says: Gene editing widely used in range of research

Associated Press  

WASHINGTON — Gene editing is getting fresh attention thanks to a successful lab experiment with human embryos. _____ WHAT IS GENE EDITING While scientists have long been able to find defective genes, fixing them has been so cumbersome that it’s slowed development of genetic therapies. There are several gene editing methods, but a tool called CRISPR-Cas9 has sparked a boom …

Scientists edit disease-causing gene mutation in human embryos
7 years, 7 months ago

Scientists edit disease-causing gene mutation in human embryos

CNN  

Story highlights In first-of-its-kind study, scientists describe correcting a gene mutation tied to genetic heart conditions The researchers say they could face political barriers when it comes to further studies CNN — Scientists are getting one step closer to snipping inherited genetic diseases out of human offspring using a gene-editing technique called CRISPR. For the first time, scientists said, they …

Scientists Precisely Edit DNA In Human Embryos To Fix A Disease Gene
7 years, 7 months ago

Scientists Precisely Edit DNA In Human Embryos To Fix A Disease Gene

NPR  

Scientists Precisely Edit DNA In Human Embryos To Fix A Disease Gene Enlarge this image toggle caption Courtesy of OHSU Courtesy of OHSU Scientists have been tinkering with the DNA in humans and other living things for decades. "If irresponsible scientists are not stopped, the world may soon be presented with a fait accompli of the first baby," says David …

Gene-editing technique scientists hope will cure cancer and all inherited disease found to have dangerous flaw
7 years, 9 months ago

Gene-editing technique scientists hope will cure cancer and all inherited disease found to have dangerous flaw

The Independent  

Sign up for our free Health Check email to receive exclusive analysis on the week in health Get our free Health Check email Get our free Health Check email SIGN UP I would like to be emailed about offers, events and updates from The Independent. One of the researchers, Professor Stephen Tsang, of Columbia University, said: “We feel it’s critical …

Gene editing could bring an end to all inherited disease and cancer, expert says
8 years, 1 month ago

Gene editing could bring an end to all inherited disease and cancer, expert says

The Independent  

Sign up to our free weekly IndyTech newsletter delivered straight to your inbox Sign up to our free IndyTech newsletter Sign up to our free IndyTech newsletter SIGN UP I would like to be emailed about offers, events and updates from The Independent. Gene editing techniques that have been developed in recent years could be put to work to effectively …

To prevent serious medical conditions, scientists should be able to edit people’s DNA, panel says
8 years, 1 month ago

To prevent serious medical conditions, scientists should be able to edit people’s DNA, panel says

LA Times  

Scientists should be allowed to alter a person’s DNA in ways that will be passed on to future generations, but only to prevent serious and strongly heritable diseases, according to a new report from the National Academy of Sciences and the National Academy of Medicine. As such, the National Academies’ report acknowledges that changing heritable DNA in eggs, sperm and …

Gene editing: Should we be worried? (Opinion)
9 years, 1 month ago

Gene editing: Should we be worried? (Opinion)

CNN  

Editor’s Note: Robert Klitzman is a professor of psychiatry and director of the Masters of Bioethics Program at Columbia University. Story highlights British researchers last week given OK to use gene editing on human embryos Robert Klitzman: Tampering with nature undoubtedly has perils but also has big potential benefits CNN — Every week, I get unsolicited email ads from airlines, …

Q&A: Why CRISPR-Cas9 is being hailed as the scientific ‘Breakthrough of the Year’
9 years, 3 months ago

Q&A: Why CRISPR-Cas9 is being hailed as the scientific ‘Breakthrough of the Year’

LA Times  

CRISPR is having a moment. Scientists who use this technology say it has made targeting and changing genes in a cell’s DNA easier and more precise than ever before. Paul Knoepfler, a stem cell researcher at UC Davis, describes CRISPR as a molecular Swiss army knife: It’s part genome scanner, part scissors to cut the DNA, and part pencil to …

The War Over Genome Editing Just Got a Lot More Interesting
9 years, 5 months ago

The War Over Genome Editing Just Got a Lot More Interesting

Wired  

If you want to drop some real DNA editing knowledge—like, I don’t know, at a party!—here’s a tip. Today, gene-editing scientists dropped some curious news: They’ve found a CRISPR system involving a different protein that also edits human DNA, and, in some cases, it may work even better than Cas9. “There are definitely many more defense systems out there, and …

Crispr: The science behind a 'game-changing' gene-editing technique
9 years, 7 months ago

Crispr: The science behind a 'game-changing' gene-editing technique

The Independent  

Sign up for our free Health Check email to receive exclusive analysis on the week in health Get our free Health Check email Get our free Health Check email SIGN UP I would like to be emailed about offers, events and updates from The Independent. Read our privacy policy It has been less than five years since it was first …

America Needs to Figure Out the Ethics of Gene Editing Now
9 years, 11 months ago

America Needs to Figure Out the Ethics of Gene Editing Now

Wired  

In an international first, researchers in China have reported doing experiments that involve editing the genome of a human embryo. In the research, published a week ago in the journal Protein and Cell, the scientists used a powerful new DNA-editing method called CRISPR/Cas9 to replace the genes that cause a potentially deadly blood disorder. Within the past few months, several …

Human embryo ‘editing’ sparks international debate
9 years, 11 months ago

Human embryo ‘editing’ sparks international debate

The Hindu  

In a world’s first, Chinese scientists have reported “editing” the genomes of human embryos. These rumours sparked a high-profile debate recently about the ethical implications of such work, the scientific journal Nature reported, citing the study that first appeared in the journal Protein & Cell. In the paper, researchers led by Junjiu Huang, a gene-function researcher at Sun Yat-sen University …

A CRISPR Way To Fix Faulty Genes
10 years, 8 months ago

A CRISPR Way To Fix Faulty Genes

NPR  

A CRISPR Way To Fix Faulty Genes Enlarge this image toggle caption Illustration courtesy of Jennifer Doudna/UC Berkeley Illustration courtesy of Jennifer Doudna/UC Berkeley Scientists from many areas of biology are flocking to a technique that allows them to work inside cells, making changes in specific genes far faster — and for far less money — than ever before. "It's …

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