Scientists Attempt Controversial Experiment To Edit DNA In Human Sperm Using CRISPR
5 years, 7 months ago

Scientists Attempt Controversial Experiment To Edit DNA In Human Sperm Using CRISPR

NPR  

Scientists Attempt Controversial Experiment To Edit DNA In Human Sperm Using CRISPR Enlarge this image toggle caption Elias Williams for NPR Elias Williams for NPR First it was human embryos. "It doesn't matter whether you're manipulating the embryo or you're manipulating the sperm," says Françoise Baylis, a bioethicist at Dalhousie University in Canada, who is advising the World Health Organization about gene editing. "There's reason to worry about undertaking the research before we've asked the question properly whether we would ever actually want to use those techniques," says Ben Hurlbut, a bioethicist at Arizona State University in Tempe. "Nobody's tried to do CRISPR on sperm before, so we have to try to figure out the right way to do it," Wang says.

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History of this topic

The controversial scientist He Jiankui hasn’t given up on gene-edited babies
1 month ago

The controversial scientist He Jiankui hasn’t given up on gene-edited babies

The Economist  

T he world was shocked in 2018 when He Jiankui, a Chinese biophysicist, announced that he had helped to produce two girls whose genetic code he had edited when they had been embryos. Scientists around the world condemned the work as wildly premature and possibly dangerous—the Chinese authorities agreed and Dr He was imprisoned for three years. And he still …

S. Africa’s new research guidelines not a green light for heritable human genome editing
3 months, 2 weeks ago

S. Africa’s new research guidelines not a green light for heritable human genome editing

Raw Story  

The recently updated South African Ethics in Health Research Guidelines have been a recent cause of concern, with some researchers and bioethicists interpreting them as allowing what’s known as heritable human genome editing. Rather than allowing heritable human genome editing, the guidelines acknowledge the reality that South African law already allows human genome editing. That this was the purpose is …

Editing fetal genomes is on the horizon. We need to talk about it now
7 months, 1 week ago

Editing fetal genomes is on the horizon. We need to talk about it now

Salon  

With their primary goal to advance scientific knowledge, most scientists are not trained or incentivized to think through the societal implications of the technologies they are developing. In 2015, three years after scientists discovered how to permanently edit the human genome, U.S. scientists issued a statement to halt applications of germline genome editing, a controversial type of gene editing where …

Guideline sets ethical rules for human genome editing research
8 months, 2 weeks ago

Guideline sets ethical rules for human genome editing research

China Daily  

China on Wednesday released a guideline that lays out a set of ethical rules for human genome editing research. Regarding clinical research involving genome editing of somatic cells — which are cells in the body other than sperm and egg cells, it said that such research should be aimed at preventing or treating diseases and should be carried out after …

Documentary spurs a new look at the case of the first gene-edited babies
2 years, 3 months ago

Documentary spurs a new look at the case of the first gene-edited babies

Salon  

In the four years since an experiment by disgraced scientist He Jiankui resulted in the birth of the first babies with edited genes, numerous articles, books and international commissions have reflected on whether and how heritable genome editing – that is, modifying genes that will be passed on to the next generation – should proceed. Creation of the 'CRISPR babies' …

A Bold Effort to Cure HIV—Using Crispr
2 years, 5 months ago

A Bold Effort to Cure HIV—Using Crispr

Wired  

In July, an HIV-positive man became the first volunteer in a clinical trial aimed at using Crispr gene editing to snip the AIDS-causing virus out of his cells. “What we’re trying to do is return the cell to a near-normal state,” says Daniel Dornbusch, CEO of Excision BioTherapeutics, the San Francisco-based biotech company that’s running the trial. “HIV is a …

CRISPR gene editing can cause unwanted changes in human embryos, study finds
4 years, 4 months ago

CRISPR gene editing can cause unwanted changes in human embryos, study finds

Firstpost  

Instead of addressing genetic mutations, the CRISPR-Cas9 technology appeared to wreak genetic havoc in about half the specimens that the researchers examined A powerful gene-editing tool called CRISPR-Cas9, which this month nabbed the Nobel Prize in Chemistry for two female scientists, can cause serious side effects in the cells of human embryos, prompting them to discard large chunks of their …

Lab tests show risks of using CRISPR gene editing on embryos
4 years, 4 months ago

Lab tests show risks of using CRISPR gene editing on embryos

The Independent  

For free real time breaking news alerts sent straight to your inbox sign up to our breaking news emails Sign up to our free breaking news emails Sign up to our free breaking news emails SIGN UP I would like to be emailed about offers, events and updates from The Independent. Read our privacy policy A lab experiment aimed at …

Lab tests show risks of using CRISPR gene editing on embryos
4 years, 4 months ago

Lab tests show risks of using CRISPR gene editing on embryos

Associated Press  

A lab experiment aimed at fixing defective DNA in human embryos shows what can go wrong with this type of gene editing and why leading scientists say it’s too unsafe to try. “If our results had been known two years ago, I doubt that anyone would have gone ahead” and tried it on embryos intended for pregnancy, said biologist Dieter …

Too Soon to Give Green Signal to Techniques of Genome Editing for Human Embryo, Say Scientists
4 years, 6 months ago

Too Soon to Give Green Signal to Techniques of Genome Editing for Human Embryo, Say Scientists

News 18  

Techniques to genetically-edit human embryos should not be used until they are proved to be reliable and safe, an international commission said Thursday, in the wake of a scandal over gene-modified babies in China two years ago. Experts from the commission of the US National Academy of Medicine, US National Academy of Sciences, and Britain’s Royal Society said heritable genome …

Still too soon to try altering human embryo DNA, panel says
4 years, 6 months ago

Still too soon to try altering human embryo DNA, panel says

Associated Press  

It’s still too soon to try to make genetically edited babies because the science isn’t advanced enough to ensure safety, says an international panel of experts who also mapped a pathway for any countries that want to consider it. If drugs or gene therapy after birth can treat a disease, “then it doesn’t make sense to me to layer the …

It’s still too soon to try altering the DNA of human embryos, scientific panel says
4 years, 6 months ago

It’s still too soon to try altering the DNA of human embryos, scientific panel says

LA Times  

It’s still too soon to try to genetically edited human embryos because the science isn’t advanced enough to ensure safety, according to a report by an international panel of experts who also mapped a pathway for any countries that want to consider it. Thursday’s report comes nearly two years after a Chinese scientist shocked the world by revealing he’d helped …

Scientists claim to have uses CRISPR for the first time to treat a patient who was blind
5 years ago

Scientists claim to have uses CRISPR for the first time to treat a patient who was blind

Firstpost  

They said that it will take up to a month to see if this surgery worked and has restored the patient’s vision. Scientists say they have used the gene-editing tool CRISPR inside someone’s body for the first time, a new frontier for efforts to operate on DNA, the chemical code of life, to treat diseases. “We think it could open …

Never-seen-before extracts from 'outrageous' research of disgraced scientist He Jiankui
5 years, 3 months ago

Never-seen-before extracts from 'outrageous' research of disgraced scientist He Jiankui

Daily Mail  

He Jiankui, the disgraced scientist who was internationally condemned for gene-editing twin girls, may have put the health of the children at risk by adding unintended mutations into their genetic code. Dr Vassena adds: 'The idea that editing-derived embryos may one day be able to 'control the HIV epidemic,' as the authors claim, is preposterous. 'It's almost like not editing …

The World Health Organization Says No More Gene-Edited Babies
55 years, 2 months ago

The World Health Organization Says No More Gene-Edited Babies

Wired  

The world’s largest public health authority has weighed in with the most authoritative statement yet on the use of Crispr to alter the DNA of human babies. Eight months after a rogue Chinese scientist revealed he had secretly created the world’s first gene-edited children, the World Health Organization is asking countries to put a stop to any experiments that would …

First U.S. Patients Treated With CRISPR As Human Gene-Editing Trials Get Underway
5 years, 11 months ago

First U.S. Patients Treated With CRISPR As Human Gene-Editing Trials Get Underway

NPR  

Patients Treated With CRISPR As Human Gene-Editing Trials Get Underway Enlarge this image toggle caption Molekuul/Getty Images/Science Photo Library Molekuul/Getty Images/Science Photo Library The powerful gene-editing technique called CRISPR has been in the news a lot. Sponsor Message Research News Scientists Plan To Start Human Trials Testing CRISPR Soon Scientists Plan To Start Human Trials Testing CRISPR Soon 4:30 One …

CRISPR: The genetic editing tool that holds promise & peril
6 years, 3 months ago

CRISPR: The genetic editing tool that holds promise & peril

Live Mint  

Chinese researcher He Jiankui has claimed that he used CRISPR to produce the world’s first “designer babies”. Jiankui said he used CRISPR—Clustered Regularly Interspaced Short Palindromic Repeats—to alter the genes of a pair of twins while they were embryos to make the babies resistant to HIV, the virus that causes AIDS. In 2017, a US science and medicine advisory group …

China baby gene-editing scientist defends his research, raises possibility of third embryo
6 years, 3 months ago

China baby gene-editing scientist defends his research, raises possibility of third embryo

CNN  

Hong Kong CNN — The Chinese scientist who sparked an international outcry after alleging to have helped create the world’s first genetically edited babies has raised the possibility of a third child being born, after announcing that a separate woman was pregnant at an early stage with a modified embryo. He said his research has been submitted to a scientific …

Facing Backlash, Chinese Scientist Defends Gene-Editing Research On Babies
6 years, 3 months ago

Facing Backlash, Chinese Scientist Defends Gene-Editing Research On Babies

NPR  

Facing Backlash, Chinese Scientist Defends Gene-Editing Research On Babies Enlarge this image toggle caption Kin Cheung/AP Kin Cheung/AP Updated at 6:15 a.m. Enlarge this image toggle caption Kin Cheung/AP Kin Cheung/AP She spoke after Harvard Medical School Dean George Daley alluded to He's claims as "missteps" that he worried might set back a highly promising field of research. "Just because …

Inventor of CRISPR calls for a global moratorium on gene-edited embryos, humans
6 years, 3 months ago

Inventor of CRISPR calls for a global moratorium on gene-edited embryos, humans

Firstpost  

The risks of such an experiment are still far greater than its benefits, Zhang said in a statement. A Harvard and MIT member, renowned genetic research Feng Zhang made the statement after a Chinese researcher claimed having helped create the world’s first babies with modified genes using CRISPR. The researcher claiming to have contributed to the success of the gene-editing …

Scientists, officials in China abhor gene editing that geneticist claims
6 years, 3 months ago

Scientists, officials in China abhor gene editing that geneticist claims

Live Mint  

Beijing/Shanghai: Chinese officials and scientists denounced on Tuesday the claims of a geneticist who said he had created the first gene-edited babies, and a hospital linked to his research suggested its ethical approval had been forged. China’s Genetics Society and the Chinese Society for Stem Cell Research said in a statement He had acted as an “individual” and his work …

World's first CRISPR gene-edited babies claimed by Chinese researcher as success
6 years, 3 months ago

World's first CRISPR gene-edited babies claimed by Chinese researcher as success

Firstpost  

Society will decide what to do next in terms of allowing or forbidding such science: Researcher. It’s “unconscionable … an experiment on human beings that is not morally or ethically defensible,” said Dr Kiran Musunuru, a University of Pennsylvania gene editing expert and editor of a genetics journal. It’s a big deal.” However, one famed geneticist, Harvard University’s George Church, …

China orders probe into first ‘gene-edited babies’
6 years, 3 months ago

China orders probe into first ‘gene-edited babies’

Al Jazeera  

Scientists denounce claims by Chinese geneticist as concerns are raised about its safety and ethics. We still might have a glimmer of hope to close it before it's too late by Scientists say in an open letter The government’s medical ethics committee in Shenzhen said it was investigating the case, as was the Guangdong provincial health commission, according to Southern …

First gene-edited babies are here: Here's a look at the complete experiment
6 years, 4 months ago

First gene-edited babies are here: Here's a look at the complete experiment

India Today  

In a first, genetically edited babies have been welcomed by the world. In an interview to Associated Press, Shenzhen said he altered embryos for seven couples during fertility treatments, with one pregnancy resulting thus far. In all, 16 of 22 embryos were edited, and 11 embryos were used in six implant attempts before the twin pregnancy was achieved, he said …

Q&A: Why geneticists say it’s wrong to edit the DNA of embryos to protect them against HIV
6 years, 4 months ago

Q&A: Why geneticists say it’s wrong to edit the DNA of embryos to protect them against HIV

LA Times  

An embryo receives a small dose of gene-editing proteins and RNA in a sperm injection microscope in a Shenzhen laboratory. Chinese scientist He Jiankui of Shenzhen Harmonicare Women’s and Children’s Hospital revealed that he had edited the DNA in a pair of human embryos, disabling a gene required for HIV infection to take hold. He Jiankui’s claim that he helped …

Editing our genes
6 years, 6 months ago

Editing our genes

The Hindu  

American biochemist Jennifer Doudna, one of the pioneers of the gene editing tool Crispr-Cas9, woke up in a cold sweat after she dreamt of Adolf Hitler. In the book she co-authored, A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution, Doudna recounts the dream, and acknowledges the “truly incredible power” of the technology, “one that could …

WHAT IS CRISPR-CAS9?
7 years, 3 months ago

WHAT IS CRISPR-CAS9?

Daily Mail  

The approach has been used previously to edit the HBB gene responsible for a condition called β-thalassaemia. Get ready for genetically engineered 'super chocolate': Scientists use gene editing tools to make cacao trees resistant to disease Gene-editing tool CRISPR-Cas9 could help breed cacao trees that exhibit desirable traits such as enhanced resistance to diseases, a Penn. Revolutionary gene-editing tool CRISPR …

Scientists edit gene for blood disease in human embryos
7 years, 5 months ago

Scientists edit gene for blood disease in human embryos

CNN  

Story highlights A complex gene-editing technique was used to correct a mutation in embryos One expert describes the technique as "chemical surgery" CNN — In the future, it might be possible to prevent inherited illnesses by making a change to a single faulty gene. For the first time, scientists used a controversial gene-editing technique called base editing to correct a …

CRISPR gene editing technique sheds light on key gene for human embryo development
7 years, 6 months ago

CRISPR gene editing technique sheds light on key gene for human embryo development

Firstpost  

The findings could help scientists to better understand the biology of our early development and lead to new treatment for infertile couples. In a first, researchers have used the CRISPR-Cas9 gene-editing technique to reveal the role of a key gene in human embryos in the first few days of development. The findings published in the journal Nature could help scientists …

Gene editing of human embryos in UK reveals new fertility clue
7 years, 6 months ago

Gene editing of human embryos in UK reveals new fertility clue

CNN  

Story highlights UK scientists have edited human embryos for the first time A key gene has been identified that helps determine the healthy development of human embryos CNN — The DNA of human embryos has been altered and studied for the first time in the UK, offering new insight into the early stages of human development. “We were surprised to …

If you could edit your child's genes, would you?
7 years, 6 months ago

If you could edit your child's genes, would you?

Salon  

In early August, Nature reported that an international group of scientists used CRISPR–Cas9 gene editing technology to correct a mutation in the DNA in human embryos. Recently on Salon Talks, Dr. Alan Copperman, the director of the division of reproductive endocrinology and infertility at Mount Sinai Medical Center, laid out both the science and the ethical considerations. It’s Clustered Regularly …

For first time ever, scientists are able to edit DNA in human embryos through CRISPR technique!
7 years, 7 months ago

For first time ever, scientists are able to edit DNA in human embryos through CRISPR technique!

India TV News  

In a recent breakthrough, US scientists have been able to modify genes of a human embryo to correct a disease-causing mutation. "We have demonstrated the possibility to correct mutations in a human embryo in a safe way and with a certain degree of efficiency," said Juan Carlos Izpisua Belmonte, a professor in Salk's Gene Expression Laboratory and a co-author of …

Science Says: Gene editing widely used in range of research
7 years, 7 months ago

Science Says: Gene editing widely used in range of research

Associated Press  

WASHINGTON — Gene editing is getting fresh attention thanks to a successful lab experiment with human embryos. _____ WHAT IS GENE EDITING While scientists have long been able to find defective genes, fixing them has been so cumbersome that it’s slowed development of genetic therapies. There are several gene editing methods, but a tool called CRISPR-Cas9 has sparked a boom …

Scientists edit disease-causing gene mutation in human embryos
7 years, 7 months ago

Scientists edit disease-causing gene mutation in human embryos

CNN  

Story highlights In first-of-its-kind study, scientists describe correcting a gene mutation tied to genetic heart conditions The researchers say they could face political barriers when it comes to further studies CNN — Scientists are getting one step closer to snipping inherited genetic diseases out of human offspring using a gene-editing technique called CRISPR. For the first time, scientists said, they …

Scientists Precisely Edit DNA In Human Embryos To Fix A Disease Gene
7 years, 7 months ago

Scientists Precisely Edit DNA In Human Embryos To Fix A Disease Gene

NPR  

Scientists Precisely Edit DNA In Human Embryos To Fix A Disease Gene Enlarge this image toggle caption Courtesy of OHSU Courtesy of OHSU Scientists have been tinkering with the DNA in humans and other living things for decades. "If irresponsible scientists are not stopped, the world may soon be presented with a fait accompli of the first baby," says David …

Scientists edit human genes for the first time ever in the US
7 years, 7 months ago

Scientists edit human genes for the first time ever in the US

The Independent  

Sign up to our free weekly IndyTech newsletter delivered straight to your inbox Sign up to our free IndyTech newsletter Sign up to our free IndyTech newsletter SIGN UP I would like to be emailed about offers, events and updates from The Independent. Read our privacy policy Scientists have genetically engineered a human embryo for the first time in the …

Report: Scientists edit human embryos for first time in US
7 years, 7 months ago

Report: Scientists edit human embryos for first time in US

CNN  

Story highlights A first in the US, scientists reportedly edit the genes of human embryos using CRISPR Yet the research hasn't been published and researchers remain tight-lipped CNN — America reportedly has moved ahead in a controversial race to tinker with human DNA – but the scientific feat is shrouded in unanswered questions. “I’m not surprised that they were looking …

An unedited mutation
8 years ago

An unedited mutation

The Hindu  

Whenever there’s progress in the field of genetics, there’s cause for worry. It can be used to target specific stretches of genetic code and to edit DNA at precise locations, permanently modify genes in living cells and organisms, and possibly correct disease-causing mutations. According to the New Scientist, the team has corrected genetic mutations in a few cells in three …

U.S. Scientists Urge 'Serious Consideration' Of Gene Editing In Human Embryos
8 years, 1 month ago

U.S. Scientists Urge 'Serious Consideration' Of Gene Editing In Human Embryos

Huff Post  

Science Photo Library - ZEPHYR via Getty Images CHICAGO - Powerful gene editing tools may one day be used on human embryos, eggs and sperm to remove genes that cause inherited diseases, according to a report by U.S. scientists and ethicists released on Tuesday. The report from the National Academy of Sciences and the National Academy of Medicine said scientific …

To prevent serious medical conditions, scientists should be able to edit people’s DNA, panel says
8 years, 1 month ago

To prevent serious medical conditions, scientists should be able to edit people’s DNA, panel says

LA Times  

Scientists should be allowed to alter a person’s DNA in ways that will be passed on to future generations, but only to prevent serious and strongly heritable diseases, according to a new report from the National Academy of Sciences and the National Academy of Medicine. As such, the National Academies’ report acknowledges that changing heritable DNA in eggs, sperm and …

CRISPR-Cas9: Chinese scientists to conduct live human gene-editing trial
8 years, 8 months ago

CRISPR-Cas9: Chinese scientists to conduct live human gene-editing trial

CNN  

Story highlights Chinese scientists to conduct world's first gene-edited trial in humans Team hopes edited-genes could be used to fight lung cancer Hong Kong CNN — Chinese scientists will become the first in the world to inject people with cells modified using gene-editing technology in a groundbreaking clinical trial next month. A team led by Lu You, an oncologist at …

Chinese scientists modify gene to make humans immune to HIV
8 years, 11 months ago

Chinese scientists modify gene to make humans immune to HIV

The Hindu  

In a breakthrough in the fight against HIV/AIDS, Chinese scientists have modified a gene in embryos in an attempt to make humans immune to the HIV virus. Researchers from the Guangzhou Medical University used a gene editing technique named CRISPR/Cas to replace the CCR5 gene in 26 human embryos with an HIV—resistant mutation. “In this study, we demonstrated that the …

Chinese doctors experiment with making genetically-modified HIV-proof human embryos
8 years, 11 months ago

Chinese doctors experiment with making genetically-modified HIV-proof human embryos

Daily Mail  

Chinese scientists have been editing human embryos in an attempt to make them resistant to HIV infection. There has only ever been one previously published claim of human embryo genetic editing Chinese scientists have been editing human embryos in an attempt to make them resistant to HIV infection. The Chinese scientists tried to make human embryos resistant to HIV by …

Gene editing: Should we be worried? (Opinion)
9 years, 1 month ago

Gene editing: Should we be worried? (Opinion)

CNN  

Editor’s Note: Robert Klitzman is a professor of psychiatry and director of the Masters of Bioethics Program at Columbia University. Story highlights British researchers last week given OK to use gene editing on human embryos Robert Klitzman: Tampering with nature undoubtedly has perils but also has big potential benefits CNN — Every week, I get unsolicited email ads from airlines, …

Crispr-Cas9: Revolutionary gene editing technique named scientific breakthrough of the year
9 years, 3 months ago

Crispr-Cas9: Revolutionary gene editing technique named scientific breakthrough of the year

The Independent  

Sign up for our free Health Check email to receive exclusive analysis on the week in health Get our free Health Check email Get our free Health Check email SIGN UP I would like to be emailed about offers, events and updates from The Independent. Read our privacy policy A revolutionary technique for editing the DNA of the human genome …

Debating the ethics of human gene editing
9 years, 3 months ago

Debating the ethics of human gene editing

The Hindu  

Rewriting your DNA is getting closer to reality. It’s a question that gained urgency after Chinese researchers made the first attempt at editing genes in human embryos, a laboratory experiment that didn’t work well but did raise the prospect of one day altering human heredity passing modified DNA to future generations. At issue are tools to edit precisely genes inside …

Crispr Is Getting Better. Now It's Time to Ask the Hard Ethical Questions
9 years, 3 months ago

Crispr Is Getting Better. Now It's Time to Ask the Hard Ethical Questions

Wired  

When Chinese scientists announced in April they had edited human embryos using a new genetic tool called Crispr, the headlines blared “designer babies,” and the world woke up to Crispr’s power. Today, on the first day of an international summit on human gene editing in Washington, DC, MIT researchers announced that they have tweaked a Crispr protein to reduce those …

Chinese experiment which 'edits' DNA of human embryos ignites ethical controversy
9 years, 11 months ago

Chinese experiment which 'edits' DNA of human embryos ignites ethical controversy

ABC  

Biologists in China have carried out the first experiment to alter the DNA of human embryos, igniting an outcry from scientists who warn against altering the human genome in a way that could last for generations. Mr Huang told Nature News that if this was done on normal embryos "you need to be close to 100 per cent" on target …

America Needs to Figure Out the Ethics of Gene Editing Now
9 years, 11 months ago

America Needs to Figure Out the Ethics of Gene Editing Now

Wired  

In an international first, researchers in China have reported doing experiments that involve editing the genome of a human embryo. In the research, published a week ago in the journal Protein and Cell, the scientists used a powerful new DNA-editing method called CRISPR/Cas9 to replace the genes that cause a potentially deadly blood disorder. Within the past few months, several …

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