Fat cells can 'remember' being overweight and make it harder to shed pounds
Daily MailWeight-loss drugs have taken the world by storm, but recent studies have shown that even these miracle-workers have one fatal flaw: people often rebound to their original weight after taking them. The team used fat cells from people with obesity and people at a healthy weight to see if there were differences in their genes that could be controlling their weight gain. They found people who were obese had permanent changes to their DNA that affected how their cells use and store energy, even after they lost weight. They then studied the fat tissue from the people who had struggled with their weight and found they had consistent epigenetic changes to the parts of their genes which control energy. A recent study found the power of these epigenetic pulls to gain weight can outlast even the dramatic changes associated with using drugs that control appetite, like Ozempic or Wegovy.
History of this topic
Scientifically Speaking: Fat cell memory might contribute to weight regain
Hindustan Times)
Why is it so difficult to lose weight? ‘Fat cells’ may be the reason
Firstpost
Why losing weight is hard: Scientists have an answer
India Today
Fat tissue discovery may explain why some people easily regain lost weight
The Independent)
‘Fountain of Youth’: Can Ozempic, the weight-loss drug, help slow ageing?
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