Long overdue, short-term regimen for TB set to be a game changer
2 months, 1 week ago

Long overdue, short-term regimen for TB set to be a game changer

The Hindu  

Multidrug resistant tuberculosis is a strain of the TB disease in which the infecting tuberculosis germs are resistant to the effects of rifampicin and isoniazid, two of the most potent drugs available for TB treatment. For years, the evolution of such resistant germs was largely attributed to the lack of adherence to TB treatment and misuse of TB drugs, especially through improper drug regimens, both of which aid the selection of mutant strains of the bacterium. Linezolid is notorious for causing disabling sensory neuropathy in a proportion of patients, and such adverse effects need to be watched for, and alternative regimens clearly defined for those who may not tolerate these regimens. Since a majority of patients with TB access private healthcare as their first point of contact, we need large-scale efficient, and reliable private-public partnerships to ensure access to these regimens while preventing their abuse by making them indiscriminately available.

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History of this topic

Children, teens under-represented in drug-resistant tuberculosis cases; finds studies
1 month, 4 weeks ago

Children, teens under-represented in drug-resistant tuberculosis cases; finds studies

India TV News  

Children and teenagers treated for multidrug-resistant tuberculosis, including those in India, are under-represented in case numbers, studies have found. Reviewing previous studies, researchers analysed trends in multidrug-resistant treatment of TB in children and teenagers aged 18 or below. One of the reviews, including those from the Ministry of Health and Family Welfare, analysed 42 studies involving over 23,369 children and …

​Taking TB seriously: The Hindu Editorial on the BPaLM treatment regimen for drug-resistant tuberculosis
6 months, 2 weeks ago

​Taking TB seriously: The Hindu Editorial on the BPaLM treatment regimen for drug-resistant tuberculosis

The Hindu  

Time is of the essence in adopting advanced technology in medical care. The Union Health Ministry’s decision to introduce the new treatment regimen for drug-resistant tuberculosis hardly a couple of years after it was recommended by the World Health Organization, is a step in the right direction. This regimen has been proven to offer better outcomes, remarkably shortening the duration …

BPaLM Regimen Is the New Ray of Hope for Drug-Resistant TB
6 months, 2 weeks ago

BPaLM Regimen Is the New Ray of Hope for Drug-Resistant TB

Deccan Chronicle  

Hyderabad: Patients of drug-resistant tuberculosis in the state will soon get a new regimen, which is expected to bring down the cost and also the time of treatment from 20 months to six. BPaLM regimen, a novel treatment method for Multi-DrugResistant Tuberculosis includes a new anti-TB drug called pretomanid, which has earlier been approved and licenced for use in India …

Health ministry approves shorter, more effective treatment for multi-drug-resistant TB
6 months, 3 weeks ago

Health ministry approves shorter, more effective treatment for multi-drug-resistant TB

Hindustan Times  

The Union health ministry has approved the shorter, less toxic, and more effective treatment regimen — BPaLM— against the multi-drug-resistant tuberculosis under its National TB Elimination Program. “While traditional MDR-TB treatments can last up to 20 months with severe side effects, BPaLM regimen can cure the drug-resistant TB in just six months with high treatment success rate,” the health ministry …

Health Ministry approves new treatment regimen for multidrug-resistant TB
6 months, 3 weeks ago

Health Ministry approves new treatment regimen for multidrug-resistant TB

The Hindu  

The Union Health Ministry has approved the introduction of a new treatment regimen for drug-resistant tuberculosis in India. The BPaLM regimen consisting of four drugs — Bedaquiline, Pretomanid, Linezolid and Moxifloxacin — has proven to be a safe, more effective and quicker treatment option than the previous Multidrug-Resistant Tuberculosis treatment procedure, the Ministry said on Friday. While traditional treatments can …

Sharpening India’s anti-tuberculosis fight
7 months ago

Sharpening India’s anti-tuberculosis fight

The Hindu  

The omnipresence of tuberculosis in the pages of history and literature is testimony to how the disease has plagued generations across the world and continues to be a major problem even today. For example, in 2023, addressing the big challenge of ‘missed’ TB cases, 25.1 lakh patients were diagnosed in India as having TB, highlighting strengthened case finding efforts. It …

Eliminating TB by 2025 looks near impossible
7 months, 1 week ago

Eliminating TB by 2025 looks near impossible

Hindustan Times  

Optimism is the madness of insisting that all is well when we are miserable. The latest WHO Global TB Report reveals that India has the world’s largest TB epidemic; at 2.6 million, the country accounts for the highest number of TB cases as well as multi-drug resistant cases. A study from Mumbai highlighted an unacceptably long average delay between a …

Solving the challenge of drug-resistant TB in India
7 months, 3 weeks ago

Solving the challenge of drug-resistant TB in India

Hindustan Times  

During the recent Maharashtra assembly session, questions were raised about the rising tuberculosis cases. The current treatment options available to us in India are limited; many come with severe side effects like severe peripheral neuropathy, pink to black brown discoloration of skin lasting up to three years, and potentially even psychosis, making it an extremely difficult, and at times hopeless …

Solving the challenge of drug-resistant TB in India
7 months, 3 weeks ago

Solving the challenge of drug-resistant TB in India

Hindustan Times  

During the recent Maharashtra assembly session, questions were raised about the rising tuberculosis cases. The current treatment options available to us in India are limited; many come with severe side effects like severe peripheral neuropathy, pink to black brown discoloration of skin lasting up to three years, and potentially even psychosis, making it an extremely difficult, and at times hopeless …

TB remains a major killer disease despite use of antibiotics: Kerala expert
8 months, 2 weeks ago

TB remains a major killer disease despite use of antibiotics: Kerala expert

New Indian Express  

THIRUVANANTHAPURAM: Dr Vinay Nandicoori, director of CSIR-CCMB and a leading microbiologist, said that tuberculosis has remained as the number one killer among all infectious diseases, despite the clinical use of over 20 antibiotics and BCG, a century-old vaccine. Dr Nandicoori, a J C Bose Fellow, said that the gradual rise in the emergence of increasingly drug-resistant strains and HIV-TB co-infection …

Absence of full drug-susceptibility data for TB patients can result in amplifying resistance: study
11 months, 1 week ago

Absence of full drug-susceptibility data for TB patients can result in amplifying resistance: study

The Hindu  

In presumptive multi-drug resistant tuberculosis cases, whole genome sequencing revealed that pre-extensively drug-resistant TB was present in 50.83% of cases, while MDR-TB was found in 15.5% with nearly equivalent proportions among men and women, found a study conducted by an IIT Mumbai start-up in collaboration with Dr. D.Y. Patil Medical College, sheds light on TB dynamics in India and is …

Improved drug regimens for TB to cut treatment time
1 year, 3 months ago

Improved drug regimens for TB to cut treatment time

The Hindu  

This November, at The Union World Conference on Lung Health 2023, there was much optimism, as it seemed that there were finally tools available to fast-track work on multiple aspects of TB control. Four, new improved drug regimens that could cut treatment time for drug resistant tuberculosis by up to two thirds, were the primary source of this optimism. According …

Eight months on, States wait for 3HP TB preventive drug
1 year, 4 months ago

Eight months on, States wait for 3HP TB preventive drug

The Hindu  

Eight months after Prime Minister Narendra Modi launched the pan-India rollout of a shorter TB Preventive Treatment in March 2023 called the 3HP — once-weekly isoniazid-rifapentine for 12 weeks — States are yet to receive the 3HP combination drug from the Central TB Division. But if active TB disease is not ruled out before starting TB preventive treatment, there is …

Need to introduce DR-TB regimens that give patients a better chance at life
1 year, 7 months ago

Need to introduce DR-TB regimens that give patients a better chance at life

Live Mint  

In India’s battle against tuberculosis, a new call is rising to demand access to a new regimen for drug-resistant tuberculosis. Many who have worked in the TB space would be reminded of India’s journey in expanding access to bedaquiline, which was then the first anti-TB drug developed in the last 40 years. Despite the WHO’s recommendation to introduce bedaquiline use …

Significantly shorter treatment for drug-resistant TB likely soon
2 years ago

Significantly shorter treatment for drug-resistant TB likely soon

Hindustan Times  

Mumbai: There’s some cheer in store for drug-resistant tuberculosis patients, who have been abiding a prolonged treatment regimen with severe side-effects. HT Image The present treatment guideline, which has 13 to 14 drugs given daily for a period of 18 to 24 months, was formulated two and a half years ago. The core committee of the National TB Elimination Programme …

With over 90% Efficacy against Drug-resistant Disease, New TB Treatment Lets Experts Breathe Easy
2 years, 6 months ago

With over 90% Efficacy against Drug-resistant Disease, New TB Treatment Lets Experts Breathe Easy

News 18  

Discarding concerns of efficacy with a lower dose, a three-drugs-based new treatment regimen has a higher success rate than the existing drug-resistant TB treatment, says the latest ZeNix study published in the New England Journal of Medicine. The “bedaquiline-pretomanid-linezolid” regimen, abbreviated as the BPaL regimen, has been reported to have around 90% efficacy against highly drug-resistant tuberculosis, but the incidence …

What makes the new drug-resistant TB medicine promising
5 years, 7 months ago

What makes the new drug-resistant TB medicine promising

The Hindu  

Treating drug-resistant tuberculosis — multidrug-resistant TB and extensively drug-resistant TB — got a shot in the arm on August 14 when the U.S. Food & Drug Administration approved a new drug Pretomanid. The duration of treatment for drug-resistant TB can be drastically cut from 18-24 months to just six-nine months when pretomanid drug is used along with two already approved …

World Tuberculosis Day: New research offers hope for drug-resistant TB epidemic
6 years ago

World Tuberculosis Day: New research offers hope for drug-resistant TB epidemic

Firstpost  

Tuberculosis is the leading cause of death in the world from a single infectious disease, causing more deaths than HIV/AIDS. The STREAM trial presents robust evidence for the effectiveness and safety of the nine to an 11-month regimen when compared to the much longer 20-month regimen. Stage 1 of the trial was designed to assess whether a nine to the …

WHO revises advice on delamanid drug use in MDR-TB patients
7 years, 2 months ago

WHO revises advice on delamanid drug use in MDR-TB patients

The Hindu  

Delamanid drug, approved for use in multidrug-resistant tuberculosis patients by the World Health Organisation in October 2014, did not show any statistically significant difference in successfully curing the disease or reducing the mortality rates compared with a dummy in a Phase III human clinical trial, WHO’s position statement issued on January 15 says. The 2014 interim guidance issued by the …

The challenges of treating drug-resistant TB in India
7 years, 8 months ago

The challenges of treating drug-resistant TB in India

Al Jazeera  

‘Be prepared to take medicines for a long, long time.’ Once considered a ‘disease of the past’, TB has had a resurgence. “My family was trying to keep me positive while they paid thousands in search of the proper treatment.” While the standard course of TB drugs – between four to six different medicines – can cost as little as …

Speedy TB Treatment Could Combat Drug Resistance
8 years, 2 months ago

Speedy TB Treatment Could Combat Drug Resistance

Huff Post  

Tuberculosis in mice can be cured much faster than normal by simply tweaking the standard regimen of antibiotics, new research shows. This standard regimen evolved from the 1950s to the present by a process of adding or replacing drugs one by one, rather than by a systematic search to identify the most highly synergistic drug combinations, explained the research team …

Drug-resistant TB on the rise
11 years ago

Drug-resistant TB on the rise

The Hindu  

The growing instance of resistance to TB drugs among patients has become a major public health concern in the State, which the health authorities here are finding it difficult to deal with. Prime reason for the rise in drug resistant TB is the inherent weakness of the State-run TB control programme and lack of awareness among patients. In AP, the …

Myanmar facing ‘urgent’ drug-resistant TB threat
11 years, 7 months ago

Myanmar facing ‘urgent’ drug-resistant TB threat

Associated Press  

YANGON, Myanmar — Twice a month, Min Naing Oo visits emaciated patients at a Myanmar clinic, urging them through his face-mask to keep taking their medicine no matter how sick it makes them. Otherwise they will die — and fuel the spread of drug-resistant tuberculosis in a country that is already tallying an estimated 9,000 new infections of the hard-to-treat …

Azad says no shortage of TB drugs; WHO for regimen change
11 years, 9 months ago

Azad says no shortage of TB drugs; WHO for regimen change

The Hindu  

Even as the Union government rejected reports of shortage of tuberculosis drugs, saying fresh stocks will arrive by July-end, World Health Organisation on Friday asked India to consider changing the regimen from intermittent to daily doses. Drug resistance Another challenge of great concern, Mr Azad said, was the growing resistance to drugs due to irregular and incomplete treatment with irrational …

Drug resistant Tuberculosis (TB): Where do we go from here?
11 years, 10 months ago

Drug resistant Tuberculosis (TB): Where do we go from here?

The Hindu  

Tuberculosis or TB remains a significant health problem in Asia and Africa causing extensive human suffering and loss of life. It becomes difficult to treat XDR or extensively drug resistant TB where the bacteria become resistant not only to these two drugs but also injectable and other second-line drugs. Some of these include the limited availability of diagnosis and treatment …

A monster called drug-resistant tuberculosis
11 years, 11 months ago

A monster called drug-resistant tuberculosis

The Hindu  

Tuberculosis is a disease caused by the bacteria, Mycobacterium tuberculosis. Multidrug resistant TB is caused by bacteria that do not respond to at least Isoniazid and Rifampicin, the most powerful, first line anti-TB drugs. Drug-resistant TB occurs when drugs are not properly taken, like incomplete treatment, wrong dosage, wrong length of treatment, wrong combination, unavailability of drugs or poor quality …

UK risks time bomb of untreatable TB as number of drug-resistant cases rises rapidly
12 years ago

UK risks time bomb of untreatable TB as number of drug-resistant cases rises rapidly

The Independent  

Sign up to our free Living Well email for advice on living a happier, healthier and longer life Live your life healthier and happier with our free weekly Living Well newsletter Live your life healthier and happier with our free weekly Living Well newsletter SIGN UP I would like to be emailed about offers, events and updates from The Independent. …

Rise in TB cases attributed to discontinuation of medication
12 years ago

Rise in TB cases attributed to discontinuation of medication

The Hindu  

Tuberculosis patients’ discontinuing the prescribed medication for the prescribed time of six-months is the prime reason in the rising number of Extensively Drug Resistance Tuberculosis cases, said Pinnamaneni Siddhartha Institute of Medical Sciences Assistant Professor Karuna Murthy. XDR-TB is the second stage of TB disease that is found among the patients who do not take medicines for the complete six-months.” …

Old Drug Gets A Second Look For TB Fight
12 years, 5 months ago

Old Drug Gets A Second Look For TB Fight

NPR  

Old Drug Gets A Second Look For TB Fight Enlarge this image toggle caption Janice Haney Carr/CDC Janice Haney Carr/CDC A small study offers a bit of cautious optimism about the prospects for treatment of tuberculosis, one of humankind's most ancient scourges. "One of the major reasons for MDR-TB is inadequate treatment of plain old TB," say Dr. Anthony Fauci …

A Troubling Rise In Drug-Resistant Tuberculosis
12 years, 7 months ago

A Troubling Rise In Drug-Resistant Tuberculosis

NPR  

A Troubling Rise In Drug-Resistant Tuberculosis Enlarge this image toggle caption Karin Schermbrucker/AP Karin Schermbrucker/AP Cases of drug-resistant tuberculosis are increasing around the globe, and at a faster rate than previously thought. "The TB epidemic is driven by the HIV epidemic," Dr. Eric Goemaere, with Doctors Without Borders in Cape Town, tells Shots. Sponsor Message In the township of Khayelitsha …

A Troubling Rise In Drug-Resistant Tuberculosis
12 years, 7 months ago

A Troubling Rise In Drug-Resistant Tuberculosis

NPR  

A Troubling Rise In Drug-Resistant Tuberculosis Enlarge this image toggle caption Karin Schermbrucker/AP Karin Schermbrucker/AP Cases of drug-resistant tuberculosis are increasing around the globe, and at a faster rate than previously thought. "The TB epidemic is driven by the HIV epidemic," Dr. Eric Goemaere, with Doctors Without Borders in Cape Town, tells Shots. Sponsor Message In the township of Khayelitsha …

TB treatment regimen begs for a booster dose
13 years ago

TB treatment regimen begs for a booster dose

The Hindu  

High prevalence of diabetes in the community and improper treatment and follow-up of standard tuberculosis treatment have been fuelling drug-resistant tuberculosis in the State. Kerala has been reporting high levels of failure of standard TB treatment using first-line drugs primarily because of the increasing prevalence of diabetes, public health professionals point out. Diabetes and poly drug resistance are the primary …

TB control must not be left in the dark
13 years ago

TB control must not be left in the dark

The Hindu  

March 24 is World TB Day, and a good time to take stock of progress in tuberculosis control, especially in India, the country with the largest number of TB cases. Drug-resistant form India's Revised National Tuberculosis Control Programme is widely appreciated for having made a big contribution by expanding basic diagnostic and treatment services to cover 100 per cent of …

India needs to show urgency on drug resistant TB
13 years ago

India needs to show urgency on drug resistant TB

The Hindu  

The growing number of drug-resistant tuberculosis cases in India calls for greater urgency to solve major problems surrounding the treatment of TB and regulation of TB drugs in the country’s private market, the international medical humanitarian organization Médecins Sans Frontières / Doctors Without Borders said here on Friday. “The conditions for emergence of drug resistance are undeniably prevalent, in both …

MSF: Alarming scope of drug-resistant TB
13 years ago

MSF: Alarming scope of drug-resistant TB

China Daily  

A medical aid group says the spread of multi-drug-resistant tuberculosis is much greater than previously thought. "Wherever we're looking for drug-resistant TB we're finding it in very alarming numbers. The MSF medical director says MDR-TB can go unnoticed during a routine TB exam. Shanks says there's little incentive to discover new TB drugs. We're really pushing now that there is …

India's TB treatment strategy stands vindicated
15 years, 6 months ago

India's TB treatment strategy stands vindicated

The Hindu  

Research based on a study commissioned by the World Health Organisation, and published online in the Open Access journal PLoS Medicine, has clearly vindicated India’s position on treating newly diagnosed TB patients. India has been facing much criticism for treating patients for six months using a different regimen where drugs are given only thrice a week and not daily as …

Better Control of TB seen if a faster cure is found -英语点津
18 years, 7 months ago

Better Control of TB seen if a faster cure is found -英语点津

China Daily  

Better Control of TB seen if a faster cure is found http://language.chinadaily.com.cn/audio/special/2006/08/0808a.mp3 This is the VOA Special English Development Report. Joshua Salomon says a shorter treatment program would likely mean not just more patients cured. The model shows that these reductions would take place between two thousand twelve and two thousand thirty. Health workers watch tuberculosis patients take their daily …

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