Making pig livers humanlike in quest to ease organ shortage
1 year, 11 months ago

Making pig livers humanlike in quest to ease organ shortage

LA Times  

A pig liver that has been “decelled” is held by a technician in a Micromatrix laboratory in Eden Prairie, Minn. This is a pig liver that’s gradually being transformed to look and act like a human one, part of scientists’ long quest to ease the nation’s transplant shortage by bioengineering replacement organs. And if that novel “liver assist” works, it would be a critical step toward eventually attempting a bioengineered organ transplant — probably a kidney. “If you can just get over the hump, then you might actually recover” — because the liver is the only organ that can repair itself and regrow, said Mount Sinai’s Florman. While regrowing kidneys isn’t as far along, “I was completely stunned” at the progress so far, said Dr. Ron Shapiro, a kidney transplant expert at Mount Sinai.

Long Human Cells Ross Fda Transplant Mount Sinai Liver Organs Pig Organ Miromatrix  cells  quest  transplant  pig  organ  livers  liver  kidneys  shortage  long  humanlike  making  ease  organs  miromatrix  human

History of this topic

Who wants a pig organ? Patients sick and tired of waiting years for a transplant
6 days, 16 hours ago

Who wants a pig organ? Patients sick and tired of waiting years for a transplant

India Today  

LOUISVILLE, Ky. : The calls and emails started coming into NYU Langone Health and Massachusetts General Hospital soon after doctors began experimenting with pig organs in humans. “I think it’s worth the shot.” Now two U.S. companies aim to begin the world’s first clinical trials of xenotransplantation in 2025 – using pig kidneys or hearts to try to save human …

Tired of long organ waitlists, these patients are hopeful for a pig organ transplant
1 week ago

Tired of long organ waitlists, these patients are hopeful for a pig organ transplant

Associated Press  

LOUISVILLE, Ky. — The calls and emails started coming into NYU Langone Health and Massachusetts General Hospital soon after doctors began experimenting with pig organs in humans. Pig kidney recipient Towana Looney sits with transplant surgeon Dr. Jayme Locke on Dec. 10, 2024, at NYU Langone Health, in New York City. Share Share Copy Link copied Email Facebook X Reddit …

We could grow organs in space and bring them to Earth for transplants, research suggests
2 months ago

We could grow organs in space and bring them to Earth for transplants, research suggests

The Independent  

Sign up to our free weekly IndyTech newsletter delivered straight to your inbox Sign up to our free IndyTech newsletter Sign up to our free IndyTech newsletter SIGN UP I would like to be emailed about offers, events and updates from The Independent. Read our privacy policy Scientists hope to grow organs in space and bring them back down to …

Meet the world’s cleanest pigs – raised to grow kidneys and hearts for humans
5 months ago

Meet the world’s cleanest pigs – raised to grow kidneys and hearts for humans

The Independent  

The best of Voices delivered to your inbox every week - from controversial columns to expert analysis Sign up for our free weekly Voices newsletter for expert opinion and columns Sign up to our free weekly Voices newsletter Please enter a valid email address Please enter a valid email address SIGN UP I would like to be emailed about offers, …

Meet Some of the World’s Cleanest Pigs, Raised to Grow Kidneys and Hearts for Humans
5 months ago

Meet Some of the World’s Cleanest Pigs, Raised to Grow Kidneys and Hearts for Humans

Deccan Chronicle  

Blacksburg: Wide-eyed piglets rushing to check out the visitors to their unusual barn just might represent the future of organ transplantation – and there’s no rolling around in the mud here. “These are precious animals,” said David Ayares of Revivicor Inc., who spent decades learning to clone pigs with just the right genetic changes to allow those first audacious experiments. …

Pig transplant research yields a surprise: Bacon safe for some people allergic to red meat
5 months ago

Pig transplant research yields a surprise: Bacon safe for some people allergic to red meat

Associated Press  

BLACKSBURG, Va. — Some people who develop a weird and terrifying allergy to red meat after a bite from a lone star tick can still eat pork from a surprising source: Genetically modified pigs created for organ transplant research. While xenotransplants still are experimental, Revivicor’s “GalSafe” pigs won Food and Drug Administration approval in 2020 to be used as a …

Alien organs give hope of longer life
6 months, 3 weeks ago

Alien organs give hope of longer life

China Daily  

Medical experts perform a surgery to transplant blood vessels from a genetically edited pig to the abdominal wall of a recipient monkey at Xijing Hospital at the Air Force Military Medical University in Xi'an, Shaanxi province. ZENG XIANHUI/FOR CHINA DAILY The world's fifth living-body alien organ transplant, the first liver transplant from a pig to a living human, was successfully …

Scientifically Speaking | Pig organ transplants offer lifeline to waiting patients
8 months, 3 weeks ago

Scientifically Speaking | Pig organ transplants offer lifeline to waiting patients

Hindustan Times  

Earlier this month, surgeons at Massachusetts General Hospital in Boston achieved a first in medicine when they successfully transplanted a genetically modified pig kidney into a 62-year-old man. Following the failure of a previous kidney transplant and life-threatening complications from dialysis, a pig kidney transplant now offers Richard “Rick” Slayman a solution that could potentially save his life. Also, in …

US surgeons transplanted pig kidney into patient for the first time, hospital says
9 months ago

US surgeons transplanted pig kidney into patient for the first time, hospital says

Associated Press  

NEW YORK — Doctors in Boston have transplanted a pig kidney into a 62-year-old patient, the latest experiment in the quest to use animal organs in humans. Massachusetts General Hospital said Thursday that it’s the first time a genetically modified pig kidney has been transplanted into a living person. He noted that unlike the pig heart recipients who were very …

A first-ever experiment shows how pigs might one day help people who have liver failure
11 months ago

A first-ever experiment shows how pigs might one day help people who have liver failure

Associated Press  

Surgeons externally attached a pig liver to a brain-dead human body and watched it successfully filter blood, a step toward eventually trying the technique in patients with liver failure. In this case, the pig liver was used outside the donated body, not inside — a way to create a “bridge” to support failing livers by doing the organ’s blood-cleansing work …

Gene-edited pig kidney keeps monkey alive for 2 years, trial finds, a step toward longer-lasting human transplants
1 year, 2 months ago

Gene-edited pig kidney keeps monkey alive for 2 years, trial finds, a step toward longer-lasting human transplants

CNN  

CNN — About 13 people die every day while waiting for a kidney transplant because of a lack of organ donors, but some scientists think pigs could be the answer. In a new trial that researchers say is the largest of its kind, researchers transplanted kidneys from genetically modified pigs into monkeys that lived for what’s considered a record amount …

Surgeons perform second pig heart transplant, trying to save a dying man
1 year, 3 months ago

Surgeons perform second pig heart transplant, trying to save a dying man

The Hindu  

Surgeons have transplanted a pig’s heart into a dying man in a bid to prolong his life – only the second patient to ever undergo such an experimental feat. “You know, I just keep shaking my head – how am I talking to someone who has a pig heart?” Dr. Bartley Griffith, who performed the transplant, told The Associated Press. …

Surgeons perform second pig heart transplant, trying to save a dying man
1 year, 3 months ago

Surgeons perform second pig heart transplant, trying to save a dying man

Associated Press  

WASHINGTON — Surgeons have transplanted a pig’s heart into a dying man in a bid to prolong his life – only the second patient to ever undergo such an experimental feat. “You know, I just keep shaking my head – how am I talking to someone who has a pig heart?” Dr. Bartley Griffith, who performed the transplant, told The …

Surgeons, Who Transplanted Pig Kidney in Brain-Dead Man, Say Organ Functioned Properly for 2 Months
1 year, 3 months ago

Surgeons, Who Transplanted Pig Kidney in Brain-Dead Man, Say Organ Functioned Properly for 2 Months

News 18  

US surgeons who transplanted a genetically modified pig kidney into a brain-dead patient announced Thursday they had ended their experiment after a record-breaking 61 days. “We have learned a great deal throughout these past two months of close observation and analysis, and there is great reason to be hopeful for the future,” said Robert Montgomery, director of the New York …

Pig kidney works a record 2 months in donated body, raising hope for animal-human transplants
1 year, 3 months ago

Pig kidney works a record 2 months in donated body, raising hope for animal-human transplants

Associated Press  

NEW YORK — Dozens of doctors and nurses silently lined the hospital hallway in tribute: For a history-making two months, a pig’s kidney worked normally inside the brain-dead man on the gurney rolling past them. The dramatic experiment came to an end Wednesday as surgeons at NYU Langone Health removed the pig kidney and returned the donated body of Maurice …

Pigs and human organs: The groundbreaking study setting the science world alight
1 year, 3 months ago

Pigs and human organs: The groundbreaking study setting the science world alight

The Independent  

For free real time breaking news alerts sent straight to your inbox sign up to our breaking news emails Sign up to our free breaking news emails Sign up to our free breaking news emails SIGN UP I would like to be emailed about offers, events and updates from The Independent. “Rat organs have been produced in mice, and mouse …

Scientists take ‘pioneering steps’ toward growing human kidneys in pigs
1 year, 3 months ago

Scientists take ‘pioneering steps’ toward growing human kidneys in pigs

CNN  

Editor’s note: Sign up for CNN’s Wonder Theory science newsletter. CNN — Scientists have grown kidneys containing mostly human cells inside pig embryos, an important step toward growing kidneys and potentially other human organs that could be used for transplants in people. “The main concern would be if there was much contribution of human cells to undesired lineages and the …

Pig Kidney Transplanted into Brain-Dead Man’s Body, Works Normally for a Month
1 year, 4 months ago

Pig Kidney Transplanted into Brain-Dead Man’s Body, Works Normally for a Month

News 18  

Surgeons transplanted a pig’s kidney into a brain-dead man and for over a month it worked normally — a critical step toward an operation the New York team hopes to eventually try in living patients. “It looks even better than a human kidney,” Montgomery said on July 14 as he replaced a deceased man’s own kidneys with a single kidney …

Genetically modified pig kidney still functioning 32 days after transplant into brain dead man
1 year, 4 months ago

Genetically modified pig kidney still functioning 32 days after transplant into brain dead man

The Independent  

The latest headlines from our reporters across the US sent straight to your inbox each weekday Your briefing on the latest headlines from across the US Please enter a valid email address Please enter a valid email address SIGN UP I would like to be emailed about offers, events and updates from The Independent. Please try again later {{ /verifyErrors …

Pig kidney works in a donated body for over a month, a step toward animal-human transplants
1 year, 4 months ago

Pig kidney works in a donated body for over a month, a step toward animal-human transplants

Associated Press  

NEW YORK — Surgeons transplanted a pig’s kidney into a brain-dead man and for over a month it’s worked normally — a critical step toward an operation the New York team hopes to eventually try in living patients. “It looks even better than a human kidney,” Montgomery said on July 14 as he replaced a deceased man’s own kidneys with …

Making pig livers humanlike in quest to ease organ shortage
1 year, 11 months ago

Making pig livers humanlike in quest to ease organ shortage

Associated Press  

EDEN PRAIRIE, Minn. — The ghostly form floating in a large jar had been the robust reddish-brown of a healthy organ just hours before. This is a pig liver that’s gradually being transformed to look and act like a human one, part of scientists’ long quest to ease the nation’s transplant shortage by bioengineering replacement organs. “It all sounds science …

Pig Organ Transplants Inch Closer With Testing In The Dead
2 years, 5 months ago

Pig Organ Transplants Inch Closer With Testing In The Dead

Huff Post  

In this photo provided by NYU Langone Health, surgeons prepare a genetically modified pig heart for transplant into a recently deceased donor at NYU Langone Health on Wednesday, July 6, 2022, in New York. Experiments are raising new hope that pigs might one day help fill a shortage of donated organs -- at least, for people who need a new …

Pig organ transplants inch closer with testing in the dead
2 years, 5 months ago

Pig organ transplants inch closer with testing in the dead

Associated Press  

New York researchers transplanted pig hearts into two brain-dead people over the last month, the latest in a string of developments in the long quest to one day save human lives with animal organs. Testing in the deceased could help fine-tune how the first trials in the living are designed, said Dr. David Klassen of the United Network for Organ …

US researchers test pig-to-human transplant in donated body
2 years, 11 months ago

US researchers test pig-to-human transplant in donated body

Associated Press  

Researchers on Thursday reported the latest in a surprising string of experiments in the quest to save human lives with organs from genetically modified pigs. “The organ shortage is in fact an unmitigated crisis and we’ve never had a real solution to it,” said Dr. Jayme Locke of the University of Alabama at Birmingham, who led the newest study and …

U.S. researchers test pig-to-human transplant in donated body
2 years, 11 months ago

U.S. researchers test pig-to-human transplant in donated body

LA Times  

In this photo provided by the University of Alabama at Birmingham, surgeons prepare to transplant kidneys from a genetically modified pig into the body of a deceased recipient in September 2021. “The organ shortage is, in fact, an unmitigated crisis and we’ve never had a real solution to it,” said Dr. Jayme Locke of the University of Alabama at Birmingham, …

Explained | Will the pig-to-human heart operation lead to a new approach to organ transplantation?
2 years, 11 months ago

Explained | Will the pig-to-human heart operation lead to a new approach to organ transplantation?

The Hindu  

The story so far: On January 7, David Bennett, a 57-year-old from Baltimore, Maryland, U.S. became the first person to receive a heart transplant from a genetically-modified pig. Since transplantation of a pig heart into a human, called xenotransplantation, is an experimental procedure, doctors had to seek an emergency authorisation from the U.S. FDA. In late September last year, surgeons …

In A Medical First, US Surgeons Successfully Implant Pig Heart In 57-Year-Old Man
2 years, 11 months ago

In A Medical First, US Surgeons Successfully Implant Pig Heart In 57-Year-Old Man

News 18  

US surgeons have successfully implanted a heart from a genetically modified pig in a 57-year-old man, a medical first that could one day help solve the chronic shortage of organ donations. Bennett, who has spent the last several months bedridden on a heart-lung bypass machine, added: “I look forward to getting out of bed after I recover.” The Food and …

Oink oink: Surgeons transplanted kidney grown in a pig to a human and its works perfectly
3 years, 2 months ago

Oink oink: Surgeons transplanted kidney grown in a pig to a human and its works perfectly

Firstpost  

Researchers have long sought to grow organs in pigs to transplant into humans and technologies like cloning and genetic engineering have brought the vision closer to reality in recent years. Genetically engineered pigs “could potentially be a sustainable, renewable source of organs — the solar and wind of organ availability,” Montgomery said. “This is really cutting-edge translational surgery and transplantation …

Pig-to-human transplants come a step closer with new test
3 years, 2 months ago

Pig-to-human transplants come a step closer with new test

Associated Press  

Scientists temporarily attached a pig’s kidney to a human body and watched it begin to work, a small step in the decades-long quest to one day use animal organs for life-saving transplants. Pigs have been the most recent research focus to address the organ shortage, but among the hurdles: A sugar in pig cells, foreign to the human body, causes …

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