Arthritis drug reduces death risk in patients hospitalised with Covid-19: Study
2 years, 10 months ago

Arthritis drug reduces death risk in patients hospitalised with Covid-19: Study

Hindustan Times  

An anti-inflammatory drug normally used to treat rheumatoid arthritis reduces the risk of death when given to hospitalised patients with severe Covid-19, according to a study led by researchers at the University of Oxford. Arthritis drug reduces death risk in patients hospitalised with Covid-19: Study The benefit of baricitinib is in addition to those of dexamethasone and tocilizumab, two other anti-inflammatory treatments which have previously been shown to reduce the risk of death in these patients, the researchers said. Treatment with baricitinib significantly reduced deaths: 513 of the patients in the baricitinib group died within 28 days compared with 546 patients in the usual care group, a reduction of 13 per cent, they said. "This result confirms and extends earlier findings, providing greater certainty that baricitinib is beneficial and new data to guide the treatment of Covid-19 patients with a combination of drugs to dampen the immune response,” said Sir Peter Horby, a professor at the University of Oxford, and joint chief investigator for RECOVERY.

Death Patients Risk Cent Drug Treatments Researchers Receiving Baricitinib Usual Care  patients  study  reduces  covid19  receiving  death  drug  arthritis  treatments  baricitinib  researchers  cent  risk  hospitalised  benefit

History of this topic

Scientists find arthritis drug may treat long Covid inflammation
5 months, 1 week ago

Scientists find arthritis drug may treat long Covid inflammation

India Today  

Scientists have discovered a new cause of long Covid in the lungs. Their study, published in Science Translational Medicine, indicates that a treatment previously used for rheumatoid arthritis might be effective in halting the chronic inflammation associated with long Covid. The researchers at the University of Virginia School of Medicine analysed single-cell RNA sequencing data from the lower airways of …

Remdesivir Could Reduce Covid Mortality if Given Early : Study
2 years, 1 month ago

Remdesivir Could Reduce Covid Mortality if Given Early : Study

News 18  

Remdesivir can reduce mortality in patients if administered within 9 days of COVID-19 symptom onset, according to a study conducted in Asian patients. Researchers from Tokyo Medical and Dental University have found that treatment with remdesivir within 9 days of COVID-19 symptom onset decreases mortality in Asian patients also taking corticosteroids, the study said. “In-hospital mortality rates were significantly lower …

UK health service rolls out arthritis drug Baricitinib to treat Covid
2 years, 8 months ago

UK health service rolls out arthritis drug Baricitinib to treat Covid

India Today  

The UK’s state-funded National Health Service said that from Thursday it is rolling out the use of arthritis drug Baricitinib after it has proven to save lives when given to the most seriously ill COVID patients in hospital. Typically used to treat arthritis to reduce pain and inflammation, the NHS said Baricitinib can now be given to hospitalised COVID patients …

New COVID-19 treatment rules: India cuts down use of Remdesivir, Tocilizumab, multivitamins, steroids
2 years, 11 months ago

New COVID-19 treatment rules: India cuts down use of Remdesivir, Tocilizumab, multivitamins, steroids

Firstpost  

According to the new guidelines, Remdesivir may be considered only in patients who have completed 10 days since the start of the symptoms and require supplemental oxygen. While it states that doctors can “consider Remdesivir for five days to treat hospitalised patients with COVID-19”, it also mentions that “no evidence of benefit for treatment more than five days”. Discouraging the …

India Cuts Use of Remdesivir, Tocilizumab, Multivitamins, Steroids in Covid-19 Treatment
2 years, 11 months ago

India Cuts Use of Remdesivir, Tocilizumab, Multivitamins, Steroids in Covid-19 Treatment

News 18  

India has cut down on the use of the experimental drug Remdesivir and immunosuppressive drug Tocilizumab for the treatment of Covid-19. While it states that doctors can “consider Remdesivir for five days to treat hospitalised patients with Covid-19”, it also mentions that “no evidence of benefit for treatment more than five days”. Discouraging the overuse of steroids, the protocol for …

Molnupiravir kept out of revised clinical guidelines for management of adult COVID-19 patients
2 years, 11 months ago

Molnupiravir kept out of revised clinical guidelines for management of adult COVID-19 patients

The Hindu  

The Central government hasn’t included antiviral drug Molnupiravir in its revised clinical guidance for management of adult COVID-19 patients, and specified that Remdesivir and Tocilizumab should be prescribed under certain conditions only. The guidelines were revised by the All India Institute of Medical Science and Indian Council of Medical Research -COVID-19 National Task Force/ Joint Monitoring Group, under the Health …

Baricitinib, Sotrovimab: Two New Covid-19 Treatments Approved By WHO
2 years, 11 months ago

Baricitinib, Sotrovimab: Two New Covid-19 Treatments Approved By WHO

News 18  

The World Health Organization approved two new Covid-19 treatments on Friday, growing the arsenal of tools along with vaccines to stave off severe illness and death from the virus. In their recommendation in British medical journal the BMJ, WHO experts said arthritis drug baricitinib used with corticosteroids to treat severe or critical Covid patients led to better survival rates and …

New drug could treat patients hospitalised with COVID-19 pneumonia: Lancet study
3 years ago

New drug could treat patients hospitalised with COVID-19 pneumonia: Lancet study

The Hindu  

A newly identified drug may be used to effectively treat some patients hospitalised with COVID-19 pneumonia, according to a study published in The Lancet Respiratory Medicine journal The team, including researchers from the University of Birmingham and the University of Oxford, U.K., tested namilumab— an antibody already in late-stage trials to treat rheumatoid arthritis —in patients hospitalised with COVID-19 pneumonia. …

WHO adds ‘lifesaving’ drugs for severely ill COVID-19 patients
3 years, 6 months ago

WHO adds ‘lifesaving’ drugs for severely ill COVID-19 patients

Al Jazeera  

The World Health Organization has added “lifesaving” interleukin-6 receptor blockers to its list of treatments for COVID-19 – only the second drugs to be recommended as effective against the disease – as the pandemic continues to accelerate across the world. “These drugs offer hope for patients and families who are suffering from the devastating impact of severe and critical COVID-19,” …

Lessons from COVID-19
3 years, 8 months ago

Lessons from COVID-19

The Hindu  

The SARS-CoV-2 pandemic was declared by the World Health Organization on March 11, 2020. It is important that lack of benefit of these drugs reported in well-conducted clinical trials should be translated into clinical practice by healthcare professionals managing COVID-19 patients. More recently, we have emerging evidence that two interleukin-6 receptor blocking drugs benefit COVID-19 patients, including enhanced benefit when …

They thought they were being vaccinated. It was a trial.
3 years, 10 months ago

They thought they were being vaccinated. It was a trial.

CNN  

A version of this story appeared in the February 26 edition of CNN’s Coronavirus: Fact vs. Fiction newsletter. “They told us it is the corona vaccine and we should get it so that we don’t fall sick,” said Yashoda Bai Yadav, a housewife from Bhopal who participated in the trial alongside her husband. Covid restrictions forced Russian diplomats to leave …

COVID-19 patients are being treated with drugs such as itolizumab even though there is insufficient evidence on their efficacy against the disease
4 years ago

COVID-19 patients are being treated with drugs such as itolizumab even though there is insufficient evidence on their efficacy against the disease

The Hindu  

THE COVID-19 caseload continues to rise in India, with State governments, including those of Delhi and the industrial hub Maharashtra, signalling that their States are experiencing new waves of the pandemic. It has been confirmed that during the clinical phase II trial for the drug itolizumab —which is manufactured and marketed by Biocon Biologics, a subsidiary of Biocon Limited, founded …

Health experts clash over use of certain drugs for COVID-19
4 years, 1 month ago

Health experts clash over use of certain drugs for COVID-19

Associated Press  

Health officials around the world are clashing over the use of certain drugs for COVID-19, leading to different treatment options for patients depending on where they live. On Friday, a World Health Organization guidelines panel advised against using the antiviral remdesivir for hospitalized patients, saying there’s no evidence it improves survival or avoids the need for breathing machines. Within the …

Utrecht researchers find new treatment for intubated Covid-19 patients
4 years, 1 month ago

Utrecht researchers find new treatment for intubated Covid-19 patients

NL Times  

Researchers found that existing medicine Tocilizumab, used for rheumatoid arthritis, can shorten the length of time seriously ill Covid-19 patients have to be intubated and in intensive care. Doctor and microbiologist at the Utrecht hospital Marc Bonten called it "really good news" for patients, speaking to ANP. "It is precisely for the group of seriously ill people in intensive care …

Arthritis Drug May Improve Covid-19 Survival Among Elderly Patients, Says Study
4 years, 1 month ago

Arthritis Drug May Improve Covid-19 Survival Among Elderly Patients, Says Study

News 18  

A drug used to treat rheumatoid arthritis may reduce the risk of dying for elderly patients with COVID-19, and provide a new weapon in the arsenal against the novel coronavirus, according to a study. “We urgently need to find more effective treatments for COVID-19 while we wait for a vaccine to become widely available, said Professor Justin Stebbing, co-lead author …

Steroid Treatment Should Be Reserved for Sickest Covid-19 Patients, Say Scientists
4 years, 1 month ago

Steroid Treatment Should Be Reserved for Sickest Covid-19 Patients, Say Scientists

News 18  

Most adults with moderate-to-severe COVID-19 have a suppressed immune response against the novel coronavirus rather than life-threatening hyper-inflammation, according to a study which suggests steroids such as dexamethasone should be reserved for the sickest patients. According to the research, published in the journal Science Advances, fewer than 5 per cent of the COVID-19 patients, including some of the sickest individuals, …

Timely treatment with tocilizumab likely to improve clinical outcomes in severe COVID-19 patients, finds study
4 years, 2 months ago

Timely treatment with tocilizumab likely to improve clinical outcomes in severe COVID-19 patients, finds study

Firstpost  

The drug is already approved and is used for the treatment of rheumatoid arthritis, an autoimmune disease that leads to joint inflammation and pain Patients with severe COVID-19 are likely to have short-term mortality rates between 35 percent to 62 percent, according to a study published in the journal JAMA Internal Medicine. A group of researchers at US’ Birmingham and …

WHO trial finds remdesivir has little effect on COVID-19
4 years, 2 months ago

WHO trial finds remdesivir has little effect on COVID-19

Al Jazeera  

Early results from large, randomised trial suggest antiviral does little to reduce mortality rates or time in hospital. A World Health Organization trial using four drugs including the antiviral remdesivir in the hospital treatment of COVID-19 has found the repurposed medicines have little to no effect on the length of time patients spend in hospital or their survival. “These Remdesivir, …

Steroids can be lifesaving for a few seriously ill COVID-19 patients, new studies suggests
4 years, 4 months ago

Steroids can be lifesaving for a few seriously ill COVID-19 patients, new studies suggests

Firstpost  

WHO warned against indiscriminate use of steroids, emphasizing that patients who are not severely ill are unlikely to benefit and may suffer side effects. International clinical trials published Wednesday confirm the hope that cheap, widely available steroid drugs can help seriously ill patients survive COVID-19, the illness caused by the coronavirus. Based on the new evidence, the World Health Organization …

Antibody Drug Itolizumab Lowers Risk of Death in Elderly Covid-19 Patients, Says Cuban Study
4 years, 5 months ago

Antibody Drug Itolizumab Lowers Risk of Death in Elderly Covid-19 Patients, Says Cuban Study

News 18  

An antibody drug already being used against the coronavirus in Cuba decreased the risk of intensive care admission and death among nursing home residents with moderate COVID-19, according to a small study conducted in the island nation. Researchers, including from Cuba's Center of Molecular Immunology, which developed itolizumab, said timely use of the drug in combination with standard therapy helped …

Antibody drug lowers risk of death in elderly Covid-19 patients, says study
4 years, 5 months ago

Antibody drug lowers risk of death in elderly Covid-19 patients, says study

India Today  

An antibody drug already being used against the coronavirus in Cuba decreased the risk of intensive care admission and death among nursing home residents with moderate Covid-19, according to a small study conducted in the island nation. India's Biocon Ltd said earlier this month it received regulatory approval in India for itolizumab for use in coronavirus infected patients with moderate-to-severe …

Seriously ill Covid patients showing major improvement after experimental treatment
4 years, 5 months ago

Seriously ill Covid patients showing major improvement after experimental treatment

NL Times  

Seriously ill Covid-19 patients can greatly benefit from treatment with corticosteroids, possibly in combination with a medicine that slows the functioning of the immune system, according to researchers from the Zuyderland Medical Center in Geleen and Heerlen. In their hospital, this experimental treatment reduced mortality in this patient group by as much as 65 percent, NOS reports. The doctors at …

COVID-19 treatments: Which drugs, therapies are proven to work, and which ones don’t?
4 years, 6 months ago

COVID-19 treatments: Which drugs, therapies are proven to work, and which ones don’t?

Firstpost  

We have made amazing progress in the treatment of COVID-19. Ritonavir increases the level of Lopinavir in the blood so the lopinavir/ritonavir combination was tested in a randomized controlled clinical trial for COVID-19. Steroids – yes for almost all COVID-19 patients When a synthetic steroid hormone, called dexamethasone, was given to patients with COVID-19 the drug decreased 28-day mortality by …

COVID-19 RECOVERY trial: HIV medicine found ineffective in treating hospitalised COVID-19 patients
4 years, 6 months ago

COVID-19 RECOVERY trial: HIV medicine found ineffective in treating hospitalised COVID-19 patients

Firstpost  

The HIV combination treatment lopinavir-ritonavir is also being studied in a trial by the World Health Organization. A combination of antiviral drugs used to treat HIV had no beneficial effect in patients hospitalised with COVID-19 in a large-scale randomised trial, British scientists said on Monday. Scientists running the RECOVERY trial at the University of Oxford said that the results “convincingly …

A step towards recovery
4 years, 6 months ago

A step towards recovery

The Hindu  

At a time when COVID-19 has claimed over 4,40,000 lives worldwide and a vaccine or cure is still a long way off, a breakthrough finding in the United Kingdom randomised trial presents a slender ray of hope. From among the trials of six drugs for treating COVID-19, one trial that used low-dose dexamethasone, a commonly available steroid used to reduce …

Dexamethasone shows promise in treatment of severely ill COVID-19 patients: All you need to know about the steroid drug
4 years, 6 months ago

Dexamethasone shows promise in treatment of severely ill COVID-19 patients: All you need to know about the steroid drug

Firstpost  

The Oxford University announced that dexamethasone, a common steroid drug, has shown promise in the treatment of severely ill COVID-19 patients by improving their survival rate by at least 20 percent The Oxford University announced that dexamethasone, a common steroid drug, has shown promise in the treatment of severely ill COVID-19 patients by improving their survival rate by at least …

COVID-19 'RECOVERY' Trial: Dexamethasone found life-saving in seriously-ill patients in preliminary tests
4 years, 6 months ago

COVID-19 'RECOVERY' Trial: Dexamethasone found life-saving in seriously-ill patients in preliminary tests

Firstpost  

As part of the Recovery trial, a range of potential treatments is being tested in consenting COVID-19 patients admitted to NHS hospitals in the UK. “This is the most important trial result for COVID-19 so far,” Chris Whitty, England’s Chief Medical Officer, said on Twitter about the findings of the UK-led clinical trial known as ‘RECOVERY’. “This is the first …

How dexamethasone might lead researchers to better COVID-19 treatments
4 years, 6 months ago

How dexamethasone might lead researchers to better COVID-19 treatments

LA Times  

The steroid drug dexamethasone can be lifesaving for patients with severe COVID-19. In preliminary clinical trial results announced Tuesday, patients on mechanical ventilators who were treated with the steroid dexamethasone were 35% less likely to die of COVID-19 than their counterparts who got standard care without the drug. A medication like dexamethasone is a “blunt instrument,” said Dr. Steven J. …

Dexamethasone could be the miracle drug to reduce COVID-19 mortality rate
4 years, 6 months ago

Dexamethasone could be the miracle drug to reduce COVID-19 mortality rate

Deccan Chronicle  

New Delhi: For countries battling high mortality rate due to the coronavirus pandemic, steroid Dexamethasone can be a boon, as researchers in England have claimed that it can reduce COVID-19 deaths by one-third in severely ill hospitalised patients. The chief investigators of the randomised evaluation of COVID -19 therapy trial said low-cost Dexamethasone reduces death by up to one-third in …

Indian doctors express cautious endorsement for dexamethasone for COVID-19
4 years, 6 months ago

Indian doctors express cautious endorsement for dexamethasone for COVID-19

The Hindu  

Indian doctors have said the reported success of dexamethasone — an inexpensive steroid that retails for less than ₹10 for 10 ml and is made by several Indian manufacturers — at curing COVID-19 patients on ventilators is good news for India. Scientists administering the WHO-administered RECOVERY trial — the largest global clinical trial — that is checking the ability of …

Major COVID-19 breakthrough: A cheap Dexamethasone drug 'reduces risk of death in ventilated patients'
4 years, 6 months ago

Major COVID-19 breakthrough: A cheap Dexamethasone drug 'reduces risk of death in ventilated patients'

India TV News  

A cheap, widely available steroid called dexamethasone reduced deaths by up to one third in severely ill hospitalized patients. “Dexamethasone must now be rolled out and accessed by thousands of critically ill patients around the world,” said Cammack, who had no role in the study. Researchers estimated that the drug would prevent one death for every eight patients treated while …

Dexamethasone reduces death risk in severe COVID-19 cases: Trial
4 years, 6 months ago

Dexamethasone reduces death risk in severe COVID-19 cases: Trial

Al Jazeera  

Steroid cuts risk of death by a third for patients on ventilators, by a fifth for those on oxygen, researchers say. “Based on these results, one death would be prevented by treatment of around 8 ventilated patients or around 25 patients requiring oxygen alone,” a University of Oxford statement said. Dexamethasone is inexpensive, on the shelf, and can be used …

Dexamethasone can improve COVID-19 survival, study shows
4 years, 6 months ago

Dexamethasone can improve COVID-19 survival, study shows

LA Times  

In a development that could dramatically shrink the death toll of the COVID-19 pandemic, British researchers have found that a cheap and readily available steroid prevented more than a third of the sickest patients from dying. If people are tempted to use it inappropriately, it “will cause much sicker patients,” said Dr. Steven J. O’Day, director of regional research at …

Arthritis drug may improve coronavirus patients - but experts warn effects are far from proven
4 years, 8 months ago

Arthritis drug may improve coronavirus patients - but experts warn effects are far from proven

Daily Mail  

An arthritis drug may better the conditions of severely ill coronavirus patients, a new small study suggests. Researchers tested 29 Italian coronavirus patients with anakinra, an arthritis drug, and compared them to 16 control patients In the study, 72% showed improved respiratory health and reduced signs of cytokine storms, which occur when the body attacks not just the virus but …

California doctor says arthritis drug improved coronavirus patients' symptoms within 72 hours
4 years, 8 months ago

California doctor says arthritis drug improved coronavirus patients' symptoms within 72 hours

Daily Mail  

Dr Imran Sharief, a pulmonologist from California, gave tocilizumab, a drug used to treat rheumatoid arthritis, to severely ill COVID-19 patients A California physician says a rheumatoid arthritis drug could be an effective treatment for coronavirus. Dr Imran Sharief, a pulmonologist based in Santa Ana, told Fox News that he treated COVID-19 patients on ventilators with tocilizumab, sold under the …

Discover Related