With CRISPR poised to revolutionise therapy, a pause to consider ethical issues
10 months, 2 weeks ago

With CRISPR poised to revolutionise therapy, a pause to consider ethical issues

The Hindu  

“We will each write a ghost story”, said Lord Byron; and his proposition was acceded to. With the first gene editing technology securing approval for the treatment of sickle cell anemia and beta-thalassemia, we transcend into a new revolutionary phase. Casgevy and Lyfgenia, the two cell-based gene therapies approved by the Food and Drug Administration for sickle cell anemia treatment and beta-thalassemia utilise the Nobel-winning CRISPR/Cas 9 genome editing technology. can come slowly, progressively once we have totally understood the pros and cons of the gene editing technology”, explained Dr. Chakraborty. In India every Institution involved in biomedical research is required to follow ICMR National Ethical Guidelines and register with the ethics committee which monitors research ”, said Dr. Mathur.

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History of this topic

The First Crispr Treatment Is Making Its Way to Patients
1 month, 1 week ago

The First Crispr Treatment Is Making Its Way to Patients

Wired  

Nearly a year after its approval, the first medical treatment that uses the Nobel Prize–winning technology Crispr is now being given to patients. Called Casgevy, the gene-editing treatment is for people with sickle cell disease and a related blood disorder called beta thalassemia. “Cagevy has been enthusiastically received by patients, physicians, and policymakers, and the launch is gathering momentum across …

How CRISPR can edit entire microbial populations in our gut
2 months, 2 weeks ago

How CRISPR can edit entire microbial populations in our gut

NPR  

How CRISPR can edit entire microbial populations in our gut Part 4 of the TED Radio Hour episode Augmenting Humans. Jennifer Doudna's gene-editing technology CRISPR can now manipulate populations of microbes. Together with her collaborator Emmanuelle Charpentier, Doudna has developed a technology called CRISPR-Cas9 that enables genome editing in any living cell. Web Resources Related TED Bio: Jennifer DoudnaRelated TED …

Gene Editing Needs to Be for Everyone
11 months, 2 weeks ago

Gene Editing Needs to Be for Everyone

Wired  

At the end of 2023, we witnessed an important moment in the history of medicine: For the first time, the US Food and Drug Administration approved a therapy that uses Crispr gene editing. This new therapy was developed by Crispr Therapeutics and Vertex Pharmaceuticals to treat sickle cell disease, an ailment caused by a single-letter mutation in the genetic code …

How can gene editing help cure diseases? | In Focus podcast
1 year ago

How can gene editing help cure diseases? | In Focus podcast

The Hindu  

This month, there’s been a lot of excitement in the medical world over the approval given to treatments for diseases that based on genome editing. In 2020, the Nobel Prize for Chemistry was given to two women scientists, Emmanuelle Charpentier and Jennifer Doudna for their discovery of what is essentially a genetic scissors, a tool that allows scientists to cut …

Game-changer: The Hindu Editorial on approval for gene therapy to treat sickle cell disease and beta thalassemia
1 year ago

Game-changer: The Hindu Editorial on approval for gene therapy to treat sickle cell disease and beta thalassemia

The Hindu  

Less than a month after the U.K. drug regulator approved Casgevy, the gene therapy to treat people above 12 with sickle cell disease and beta thalassemia, the U.S. FDA has approved two gene therapies — Casgevy and Lyfgenia — to treat sickle cell disease in patients over 12. By disabling the BCL11A gene, foetal haemoglobin that is produced, which does …

The First Crispr Medicine Is Now Approved in the US
54 years, 11 months ago

The First Crispr Medicine Is Now Approved in the US

Wired  

“This is a terrible disease,” says Samarth Kulkarni, president and CEO of Crispr Therapeutics. Casgevy uses the Nobel Prize–winning technology Crispr to modify patients’ cells so that they produce healthy hemoglobin instead. Of the 31 patients followed for two years, 29 have been free of pain crises for at least a year after receiving a single dose of their own …

Jennifer Doudna Believes Crispr Is for Everyone
54 years, 11 months ago

Jennifer Doudna Believes Crispr Is for Everyone

Wired  

It’s been a monumental year for Crispr, the molecular tool scientists use to edit genetic material. This November, the United Kingdom authorized the first medical treatment using Crispr gene editing, giving people with sickle cell disease new opportunities to receive a one-time therapy to prevent episodes of terrible pain. “It’s expensive,” Jennifer Doudna, the pioneering biochemist who won a Nobel …

Crispr Wants to Feed the World
1 year, 10 months ago

Crispr Wants to Feed the World

Wired  

Ten years after its discovery, the implications of Crispr genome editing are profound and far-reaching, and we are only getting started. For instance, following on the heels of the initial clinical trial results, the first agricultural applications using Crispr have recently entered the market: A US Food and Drug Administration–approved edit to cattle genes re-creates a slick coat that is …

Gene-editing treatment shows promise for sickle cell disease
4 years ago

Gene-editing treatment shows promise for sickle cell disease

Associated Press  

Scientists are seeing promising early results from the first studies testing gene editing for painful, inherited blood disorders that plague millions worldwide, especially Black people. Doctors hope the one-time treatment, which involves permanently altering DNA in blood cells with a tool called CRISPR, may treat and possibly cure sickle cell disease and beta thalassemia. In sickle cell, defective hemoglobin leads …

CRISPR gene editing can cause unwanted changes in human embryos, study finds
4 years, 1 month ago

CRISPR gene editing can cause unwanted changes in human embryos, study finds

Firstpost  

Instead of addressing genetic mutations, the CRISPR-Cas9 technology appeared to wreak genetic havoc in about half the specimens that the researchers examined A powerful gene-editing tool called CRISPR-Cas9, which this month nabbed the Nobel Prize in Chemistry for two female scientists, can cause serious side effects in the cells of human embryos, prompting them to discard large chunks of their …

Gene editing, the good first and then the worries
4 years, 2 months ago

Gene editing, the good first and then the worries

The Hindu  

The Nobel Prize in Chemistry for 2020 which was announced on October 7, Wednesday, has two women scientists as its recipients. Emmanuelle Charpentier, a French microbiologist working at the Max Planck Unit for the Science of Pathogens in Berlin, Germany, and Jennifer A. Doudna, a biochemist from the University of California, Berkeley, U.S. shared the honour “for the development of …

Crispr: What is genome editing? All you need to know about Nobel-winning controversial technology
4 years, 2 months ago

Crispr: What is genome editing? All you need to know about Nobel-winning controversial technology

India Today  

Two women -- Emmanuelle Charpentier and Jennifer Doudna -- were awarded the 2020 Nobel Prize for chemistry by the Nobel Committee on Wednesday. The duo received the Nobel Prize in chemistry award for developing a method of genome editing, or gene editing, likened to "molecular scissors" that offers the promise of one day curing inherited diseases and even cancer. A …

Too Soon to Give Green Signal to Techniques of Genome Editing for Human Embryo, Say Scientists
4 years, 3 months ago

Too Soon to Give Green Signal to Techniques of Genome Editing for Human Embryo, Say Scientists

News 18  

Techniques to genetically-edit human embryos should not be used until they are proved to be reliable and safe, an international commission said Thursday, in the wake of a scandal over gene-modified babies in China two years ago. Experts from the commission of the US National Academy of Medicine, US National Academy of Sciences, and Britain’s Royal Society said heritable genome …

Still too soon to try altering human embryo DNA, panel says
4 years, 3 months ago

Still too soon to try altering human embryo DNA, panel says

Associated Press  

It’s still too soon to try to make genetically edited babies because the science isn’t advanced enough to ensure safety, says an international panel of experts who also mapped a pathway for any countries that want to consider it. If drugs or gene therapy after birth can treat a disease, “then it doesn’t make sense to me to layer the …

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