New method to detect novel biomarkers for kidney diseases with nephrotic syndrome: Study

A study has revealed a major advance in the identification and tracking of renal illnesses linked to nephrotic syndrome. Nephrotic syndrome, defined by increased urine protein levels, is associated with kidney disorders, including membranous nephropathy, primary focal segmental glomerulosclerosis, and minimal change disease. Damage to podocytes, the kidney's filtering cells, is the main cause of nephrotic syndrome because it permits protein to seep into the urine. Immunisation led to the phosphorylation of nephrin and notable alterations in cell structure, indicating the involvement of antibodies targeting nephrin in podocyte malfunction and nephrotic syndrome. Dr Nicola M Tomas, co-lead author of the study, commented, "The identification of anti-nephrin autoantibodies as a reliable biomarker, coupled with our hybrid immunoprecipitation technique, enhances our diagnostic capabilities and opens new avenues for closely monitoring disease progression in kidney disorders with nephrotic syndrome."