How the deadliest virus in human history paved the way for new cures
1 year, 4 months ago

How the deadliest virus in human history paved the way for new cures

The Hindu  

This is part II of a two-part story on the virus that caused the Great Influenza epidemic. The applicants wanted to recreate the H1N1 influenza virus – which had killed around 50 million people in an outbreak in 1918 – from its genetic material. He was wrong: the H1 and N1 genes of the 1918 virus made the laboratory strain so virulent that within five days, all the infected mice had died. He found that while all eight pieces of the virus’s genetic material caused severe disease, two in particular stood out: the haemagglutinin and the RNA polymerase genes. He had inserted pieces of the 1918 H1N1 virus inside a regular laboratory strain and found that doing so increased the virulence of the laboratory strain.

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