Study on Potential Approach to Stop Growth of Brain Cancer Cells
The Quint"By inhibiting one protein, PRMT5, we were able to affect a cascade of proteins involved in cell division and growth," said researcher Cheryl Arrowsmith from the University of Toronto. For the study, the team tested a group of new experimental small molecules designed to specifically inhibit key cellular enzymes being developed and studied to see if any would stop the growth of glioblastoma brain tumour cells in the laboratory. The brain tumour cells were isolated from patients' tumours and grown in the laboratory in a way that preserved the unique properties of cancer stem cells. They found that specific molecules -- precursors to actual therapeutic drugs --inhibited the same enzyme, PRMT5, stopping the growth of a large portion of these patient-derived cancer stem cells.
History of this topic
A new strategy to attack aggressive brain cancer shrank tumors in two early tests
The Independent
Drug that starves cancer cells could be first breakthrough against brain tumours for 20 years
Daily Mail)
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