Uncovering the origins of the virus that sparked a pandemic
CNNCNN — Unlocking the mysteries of the exact origins of SARS-CoV-2, the virus that causes Covid-19 and launched a global pandemic in March 2020, has become one of the most burning questions in the scientific community. “The place where all of the nearest coronaviruses are known to exist in nature is about 1,000 miles from the place where the first human cases arose,” he said, calling it a “big geographic gap.” “Second, in the place where the disease started, we have some of the world’s largest collections of bat samples, and in particular, of bat samples containing these very bat coronaviruses – the nearest known relatives. To confirm the lab-leak theory, Relman said, what’s needed is “evidence that the encounter took place in a laboratory, perhaps during the course of an experiment where, perhaps, the virus was being cultivated and they didn’t realize that they had SARS CoV-2 … evidence that a sample they never did sequence, but put into culture, in fact had SARS CoV-2, for example,” he said, adding that “there are thousands of samples” the lab hasn’t carefully sequenced yet. “It’s not close enough to say it’s the exact virus that gave rise to this one, in a simple evolutionary step,” Relman said. And despite the best efforts, it’s been 44 years since the first cases of Ebola, but as Fauci pointed out, “We haven’t yet nailed that down.” Says Relman: “We need to all accept the possibility that we may never arrive at a definite answer about where the virus and the disease first arose.” But, he said after his letter, “My impression is that there’s a growing willingness to both look at this question in a dispassionate objective way, but also to accept that there truly are multiple possibilities here.”