Lions try to close in on NFC’s top seed when they visit the eliminated 49ers

Detroit at San Francisco Monday, 8:15 p.m. EST, ESPN/ABC BetMGM NFL odds: Lions by 3 1/2. Key injuries Guard Graham Glasgow, inactive with a knee injury at Chicago, is expected to return to the lineup for Detroit.. Lions LB Jalen Reeves-Maybin may play for the first time since he had a neck injury Nov. 3 against Green Bay.. RB Isaac Guerendo is expected back for the 49ers after missing a game with a hamstring injury.. San Francisco will be missing its top two LTs with Trent Williams and Jaylon Moore both sidelined.. Series notes The Lions blew a 17-point lead and lost the NFC title game against the 49ers last season.. San Francisco has won 12 of the past 13 meetings with the only loss coming in 2015.. Detroit hasn’t won a road game in the series since Sept. 25, 1995, at Candlestick Park.. Goff has lost his past five starts against San Francisco with seven TD passes and five INTs in those games. The Lions are the NFL’s only undefeated team on the road and they’ve won a franchise-record seven games as visitors.. Detroit’s win at Chicago extended its run of avoiding consecutive losses that goes back to the first half of the 2022 season.. Goff, who is from the Bay Area and starred at California, is the only player in NFL history to throw for 300 yards or more with a 100-plus passer rating 30 times through nine seasons.. Detroit’s WR Amon-Ra St. Brown has joined Brandon Marshall and Michael Thomas as the three players in league history to have at least 100 catches in three of their first four seasons.. Sam LaPorta has 16 career TD receptions for the Lions, trailing the total of just two tight ends in their first two NFL seasons: Rob Gronkowski, who had 27, and Hall of Famer Mike Ditka, who 17.. San Francisco was eliminated from playoff contention last week and will have its first losing season since going 6-10 in 2020.. They are the only team in the NFL without a win in that scenario since Shanahan was hired in 2017.. After allowing touchdowns on 13 consecutive red zone drives over a four-week span, the 49ers have held the opposition to one TD on six trips the past two games.. San Francisco K Jake Moody has missed seven FGs this season and his 76.7% conversion rate is tied for 26th.. Niners TE George Kittle had eight catches for 106 yards and needs 33 more yards for his fourth 1,000-yard season.. San Francisco LB Fred Warner is one of two players with at least 115 tackles in seven straight seasons.. Niners DE Leonard Floyd needs 1 1/2 sacks to reach double digits for the third time in his career.. San Francisco ranks third best in the league with 6.6 yards allowed per pass attempt.