South African Covid mutation poses 're-infection risk' which could overpower vaccines, study finds
3 years, 11 months ago

South African Covid mutation poses 're-infection risk' which could overpower vaccines, study finds

Daily Mail  

The South African coronavirus mutation poses a 'significant re-infection risk' and could overpower vaccines, new research has found. Members of the public receive a dose of a Covid-19 vaccine on Wednesday at Salisbury cathedral which has been converted into a temporary vaccination centre Healthcare workers attend to a patient at the Covid-19 Intensive Care Unit of the Hospital Del Mar in Barcelona on Wednesday 'Here we show that the 501Y.V2 lineage, which contains nine spike mutations and rapidly emerged in South Africa during the second half of 2020, is largely resistant to neutralising antibodies elicited by infection with previously circulating lineages,' the authors said. Sir Patrick Vallance, the UK's chief scientific adviser, today said he would expect all vaccines to be less effective in the real world than in trials. Sir Patrick Vallance, the UK's chief scientific adviser, held a television Q&A with members of the public on Sky News this morning And there are signs the English variant of the virus has been spreading in the US for two months already, with it likely to have been in California as early as November 6. 'The full-length Spike protein is 1,273 amino acids long, so while recent variants involve multiple mutations, for instance up to eight amino acid changes in the spike protein of the B.1.1.7 strain, these represent less than a one per cent difference from the spike protein encoded by Moderna's vaccine.

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