The Substance review: 'Magnificently tasteless' horror comedy is Demi Moore's 'best big-screen role in decades' Courtesy the Cannes Film Festival Coralie Fargeat's satirical body horror The Substance, which stars Demi Moore and Margaret Qualley, will have audiences "gasping, wincing, and laughing in disbelief". No one who sees Fargeat's film will forget it In desperation, Elisabeth undergoes a mysterious DIY cloning …