
Drugs didn’t help her depression. Brain-zapping did
WiredSarah, a 36-year-old woman, has suffered from severe, unrelenting depression since childhood. It’s estimated that up to 30 per cent of people who go through treatment for depression are considered treatment-resistant, which means that they’ve tried at least two different courses of drugs to treat their condition but found little or no improvement in symptoms. Her despair led her to enrol in a trial being run at the University of California, San Francisco, which was testing the use of deep brain stimulation to treat treatment-resistant depression. During this, Sarah filled out surveys on her mood – her levels of depression, anxiety and energy – which meant that a pattern of brain activity could be linked with a specific mood fluctuation. They also found that by monitoring the activity in the region of the brain called the amygdala, which plays a role in emotional processing, they could help predict when Sarah’s symptoms would be at their most severe.
History of this topic

A brain pacemaker helped a woman with crippling depression. It may soon be available to more people
Associated Press
A surgery for depression: What is deep brain stimulation?
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The Quest to Treat Binge-Eating and Addiction—With Brain Zaps
Wired
A pacemaker for brain may treat most severe depression
India TV News
Brain stimulation acts ‘like a switch’ to turn off severe depression for one patient
CNN
Zapping 'mystery region' of the brain relieves depression symptoms study suggests
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