Fibre ‘calms immune response to asthma’
A new study has claimed that dietary fibre deters immune system from over-reacting, causing diseases such as asthma. An international team has carried out the study and found that insoluble dietary fibre, or roughage, not only keeps one fit but plays a vital role in the immune system, keeping certain diseases at bay. In their study, researchers, led by Garvan Institute of Medical Research, have demonstrated that GPR43, a molecule expressed by immune cells and previously shown to bind short chain fatty acids, functions as an anti-inflammatory receptor. Now we have a new molecular mechanism that might explain how diet is affecting our immune systems.” Mice that lack the GPR43 gene have increased inflammation, and poor ability to resolve inflammation, because their immune cells can’t bind to short chain fatty acids, the researchers found in their study. If we have low amounts of dietary fibre, then we’re going to have low levels of short chain fatty acids, which we have demonstrated are very important in the immune systems of mice.” The findings have been published in the ‘Nature’ journal.
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