Arthritis drug may improve coronavirus patients - but experts warn effects are far from proven
4 years, 8 months ago

Arthritis drug may improve coronavirus patients - but experts warn effects are far from proven

Daily Mail  

An arthritis drug may better the conditions of severely ill coronavirus patients, a new small study suggests. Researchers tested 29 Italian coronavirus patients with anakinra, an arthritis drug, and compared them to 16 control patients In the study, 72% showed improved respiratory health and reduced signs of cytokine storms, which occur when the body attacks not just the virus but its own cells. Pictured: EMS paramedics bring Zully, a COVID-19 patient, home by ambulance from Stamford Hospital in Connecticut, April 25 'Until a vaccine is available, we urgently need to find a way to help people survive the most severe symptoms of COVID-19, and to do that without overwhelming the intensive care capacity of hospital,' said Dr Lorenzo Dagna, head of the immunology, rheumatology, allergy and rare diseases unit at San Raffaele Hospital. 'Our study is the first to suggest that a high dose of the arthritis drug anakinra may be able to block the overreaction of the immune system caused by COVID-19,' Dr Guilo Cavalli, an internal medicine specialist at San Raffaele, said.

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History of this topic

Scientists find arthritis drug may treat long Covid inflammation
5 months, 1 week ago

Scientists find arthritis drug may treat long Covid inflammation

India Today  

Scientists have discovered a new cause of long Covid in the lungs. Their study, published in Science Translational Medicine, indicates that a treatment previously used for rheumatoid arthritis might be effective in halting the chronic inflammation associated with long Covid. The researchers at the University of Virginia School of Medicine analysed single-cell RNA sequencing data from the lower airways of …

Arthritis drug reduces death risk in patients hospitalised with Covid-19: Study
2 years, 10 months ago

Arthritis drug reduces death risk in patients hospitalised with Covid-19: Study

Hindustan Times  

An anti-inflammatory drug normally used to treat rheumatoid arthritis reduces the risk of death when given to hospitalised patients with severe Covid-19, according to a study led by researchers at the University of Oxford. Arthritis drug reduces death risk in patients hospitalised with Covid-19: Study The benefit of baricitinib is in addition to those of dexamethasone and tocilizumab, two other …

New drug could treat patients hospitalised with COVID-19 pneumonia: Lancet study
3 years ago

New drug could treat patients hospitalised with COVID-19 pneumonia: Lancet study

Deccan Chronicle  

London: A newly identified drug may be used to effectively treat some patients hospitalised with COVID-19 pneumonia, according to a study published in The Lancet Respiratory Medicine journal. By day 28, 78 per cent of the patients receiving namilumab were discharged from hospital or ICU, compared to 61 per cent given usual care. In the namilumab group, 11 per cent …

New drug could treat patients hospitalised with COVID-19 pneumonia: Lancet study
3 years ago

New drug could treat patients hospitalised with COVID-19 pneumonia: Lancet study

The Hindu  

A newly identified drug may be used to effectively treat some patients hospitalised with COVID-19 pneumonia, according to a study published in The Lancet Respiratory Medicine journal The team, including researchers from the University of Birmingham and the University of Oxford, U.K., tested namilumab— an antibody already in late-stage trials to treat rheumatoid arthritis —in patients hospitalised with COVID-19 pneumonia. …

Coronavirus buildup in lungs likely driver of Covid deaths: Study
3 years, 4 months ago

Coronavirus buildup in lungs likely driver of Covid deaths: Study

India Today  

Viral buildup in the lungs is the likely driver behind the steep mortality rates seen in the Covid-19 pandemic, according to a study published on Tuesday. Read | New Covid variant, C.1.2, may be more infectious, evade vaccine protection: Study The researchers found no evidence implicating a secondary bacterial infection as the cause of the deaths, although they cautioned that …

Coronavirus Buildup in Lungs Likely Behind Steep Covid-19 Death Rates: Study
3 years, 4 months ago

Coronavirus Buildup in Lungs Likely Behind Steep Covid-19 Death Rates: Study

News 18  

Viral buildup in the lungs is the likely driver behind the steep mortality rates seen in the COVID-19 pandemic, according to a study published on Tuesday. "Our findings suggest that the body's failure to cope with the large numbers of virus infecting the lungs is largely responsible for COVID-19 deaths in the pandemic," said study lead author Imran Sulaiman, an …

WHO Tests 3 Drugs for Treating Coronavirus Infection
3 years, 4 months ago

WHO Tests 3 Drugs for Treating Coronavirus Infection

News 18  

The World Health Organization says it will soon test three drugs used for other diseases to see if they might help patients sickened by the coronavirus. In a statement on Wednesday, the U.N. health agency says the three drugs would be adopted into the next phase of its ongoing global research into identifying potential treatments for COVID-19. The drugs were …

Coronavirus breakthrough in Amsterdam could reduce ICU admissions
3 years, 7 months ago

Coronavirus breakthrough in Amsterdam could reduce ICU admissions

Dutch News  

Scientists in Amsterdam say they have solved one of the most vexing puzzles of Covid-19: why some patients deteriorate rapidly just as the virus seems to be on the wane. The team at the UMC teaching hospital found that while the majority of hospital patients recover, a few produce excessive numbers of antibodies, causing potentially fatal inflammation of the lungs. …

Coronavirus breakthrough in Amsterdam could reduce ICU admissions
3 years, 7 months ago

Coronavirus breakthrough in Amsterdam could reduce ICU admissions

Dutch News  

Scientists in Amsterdam say they have solved one of the most vexing puzzles of Covid-19: why some patients deteriorate rapidly just as the virus seems to be on the wane. The team at the UMC teaching hospital found that while the majority of hospital patients recover, a few produce excessive numbers of antibodies, causing potentially fatal inflammation of the lungs. …

They thought they were being vaccinated. It was a trial.
3 years, 10 months ago

They thought they were being vaccinated. It was a trial.

CNN  

A version of this story appeared in the February 26 edition of CNN’s Coronavirus: Fact vs. Fiction newsletter. “They told us it is the corona vaccine and we should get it so that we don’t fall sick,” said Yashoda Bai Yadav, a housewife from Bhopal who participated in the trial alongside her husband. Covid restrictions forced Russian diplomats to leave …

Arthritis Drug May Improve Covid-19 Survival Among Elderly Patients, Says Study
4 years, 1 month ago

Arthritis Drug May Improve Covid-19 Survival Among Elderly Patients, Says Study

News 18  

A drug used to treat rheumatoid arthritis may reduce the risk of dying for elderly patients with COVID-19, and provide a new weapon in the arsenal against the novel coronavirus, according to a study. “We urgently need to find more effective treatments for COVID-19 while we wait for a vaccine to become widely available, said Professor Justin Stebbing, co-lead author …

Steroid Treatment Should Be Reserved for Sickest Covid-19 Patients, Say Scientists
4 years, 1 month ago

Steroid Treatment Should Be Reserved for Sickest Covid-19 Patients, Say Scientists

News 18  

Most adults with moderate-to-severe COVID-19 have a suppressed immune response against the novel coronavirus rather than life-threatening hyper-inflammation, according to a study which suggests steroids such as dexamethasone should be reserved for the sickest patients. According to the research, published in the journal Science Advances, fewer than 5 per cent of the COVID-19 patients, including some of the sickest individuals, …

Timely treatment with tocilizumab likely to improve clinical outcomes in severe COVID-19 patients, finds study
4 years, 2 months ago

Timely treatment with tocilizumab likely to improve clinical outcomes in severe COVID-19 patients, finds study

Firstpost  

The drug is already approved and is used for the treatment of rheumatoid arthritis, an autoimmune disease that leads to joint inflammation and pain Patients with severe COVID-19 are likely to have short-term mortality rates between 35 percent to 62 percent, according to a study published in the journal JAMA Internal Medicine. A group of researchers at US’ Birmingham and …

Clinical Trial of Ayurvedic Remedy for Covid-19 Shows Groundbreaking Results
4 years, 3 months ago

Clinical Trial of Ayurvedic Remedy for Covid-19 Shows Groundbreaking Results

News 18  

A groundbreaking interim report on a clinical trial being conducted in three hospitals has shown that Covid-19 patients on natural treatment are resolving most symptoms earlier than those on conventional medicines. The interim report on combination treatment of an Ayurvedic remedy called ‘Immunofree’ by Corival Life Sciences, and Nutraceutical called ‘Reginmune’ by Biogetica have shown exceptional results as against the …

New study questions cytokine storm theory of Covid-19 fatality
4 years, 3 months ago

New study questions cytokine storm theory of Covid-19 fatality

India Today  

Cytokine storm has been blamed for a large number of Covid-19 deaths. When some kind of agreement emerged among doctors and researchers over autoimmune responses such as cytokine storm, it was suggested that anti-cytokine treatments -- the ones that suppress the body's immune response -- could be beneficial in the treatment of severe cases of Covid-19. The study found significantly …

Steroids Confirmed To Help Severely Ill Coronavirus Patients
4 years, 4 months ago

Steroids Confirmed To Help Severely Ill Coronavirus Patients

News 18  

New studies confirm that multiple types of steroids improve survival for severely ill COVID-19 patients, cementing the cheap drugs as a standard of care. An analysis of pooled results from seven studies, led by the World Health Organization and published Wednesday by the Journal of the American Medical Association, found that steroids reduced the risk of death in the first …

Seriously ill Covid patients showing major improvement after experimental treatment
4 years, 5 months ago

Seriously ill Covid patients showing major improvement after experimental treatment

NL Times  

Seriously ill Covid-19 patients can greatly benefit from treatment with corticosteroids, possibly in combination with a medicine that slows the functioning of the immune system, according to researchers from the Zuyderland Medical Center in Geleen and Heerlen. In their hospital, this experimental treatment reduced mortality in this patient group by as much as 65 percent, NOS reports. The doctors at …

COVID-19 treatments: Which drugs, therapies are proven to work, and which ones don’t?
4 years, 6 months ago

COVID-19 treatments: Which drugs, therapies are proven to work, and which ones don’t?

Firstpost  

We have made amazing progress in the treatment of COVID-19. Ritonavir increases the level of Lopinavir in the blood so the lopinavir/ritonavir combination was tested in a randomized controlled clinical trial for COVID-19. Steroids – yes for almost all COVID-19 patients When a synthetic steroid hormone, called dexamethasone, was given to patients with COVID-19 the drug decreased 28-day mortality by …

The scientific process that Baba Ramdev’s potential Covid-19 medicine has to follow
4 years, 6 months ago

The scientific process that Baba Ramdev’s potential Covid-19 medicine has to follow

Hindustan Times  

Yoga guru Baba Ramdev created a sensation when he announced on Tuesday that his company Patanjali Ayurved has found a medicine for coronavirus disease Covid-19. Yoga guru Baba Ramdev and Patanjali Ayurved CEO Acharya Balkrishna launch an Ayurvedic medicine kit that they claimed can treat coronavirus patients within seven days, in Haridwar on Tuesday. The ministry of Ayurveda, Yoga & …

Coronavirus: UK Scientists testing common painkiller in fight against Covid-19
4 years, 7 months ago

Coronavirus: UK Scientists testing common painkiller in fight against Covid-19

Live Mint  

Scientists in London are testing whether a common painkiller can help patients with Covid-19 avoid potentially lethal respiratory failure and the need for mechanical ventilators. “As a new illness, there are limited treatment options for patients with Covid-19,” said Richard Beale, a professor of intensive care medicine at the NHS trust. “The clinical trial will assess whether this unique formulation …

Coronavirus | U.K. trial to test efficacy of five drugs
4 years, 7 months ago

Coronavirus | U.K. trial to test efficacy of five drugs

The Hindu  

With a range of approved drugs now being tested on COVID-19 patients, there is no clarity on which one will turn out to be more effective in treatment compared with the standard of hospital care that all patients receive. The recovery trial, coordinated by the Nuffield Department of Population Health at University of Oxford, will randomise patients to receive either …

California doctor says arthritis drug improved coronavirus patients' symptoms within 72 hours
4 years, 8 months ago

California doctor says arthritis drug improved coronavirus patients' symptoms within 72 hours

Daily Mail  

Dr Imran Sharief, a pulmonologist from California, gave tocilizumab, a drug used to treat rheumatoid arthritis, to severely ill COVID-19 patients A California physician says a rheumatoid arthritis drug could be an effective treatment for coronavirus. Dr Imran Sharief, a pulmonologist based in Santa Ana, told Fox News that he treated COVID-19 patients on ventilators with tocilizumab, sold under the …

Cardiovascular protective treatments can aid survival, recovery of COVID-19 patients: Study
4 years, 8 months ago

Cardiovascular protective treatments can aid survival, recovery of COVID-19 patients: Study

India TV News  

COVID-19 patients may be at an increased risk of cardiovascular impairment, and should be given proven protective anti-inflammatory therapies to aid survival and recovery, according to a study. "We are the first to comprehensively discuss the application of cardiovascular anti-inflammatory treatments for patients severely affected by COVID-19," said Professor Shuyang Zhang, lead author of the research, based at Peking Union …

A 1st: US study finds Gilead drug works against coronavirus
4 years, 8 months ago

A 1st: US study finds Gilead drug works against coronavirus

Associated Press  

For the first time, a major study suggests that an experimental drug works against the new coronavirus, and U.S. government officials said Wednesday that they would work to make it available to appropriate patients as quickly as possible. In a study of 1,063 patients sick enough to be hospitalized, Gilead Sciences’s remdesivir shortened the time to recovery by 31% — …

‘A drug can block coronavirus’: Gilead’s remdesivir raises hopes
4 years, 8 months ago

‘A drug can block coronavirus’: Gilead’s remdesivir raises hopes

Al Jazeera  

Top US scientist Anthony Fauci says the drug reduced the time it took for some patients to recover by 31 percent. The study, run by the US National Institutes of Health, tested remdesivir versus usual care in 1,063 hospitalised coronavirus patients around the world. At the White House, Dr Anthony Fauci, the director of the NIH’s National Institute of Allergy …

COVID-19 patients respond to Gilead's experimental drug remdesivir, says report
4 years, 8 months ago

COVID-19 patients respond to Gilead's experimental drug remdesivir, says report

India TV News  

Patients infected with the coronavirus are responding to remdesivir, an experimental drug of Gilead Sciences, news agency Reuters quoted a report as saying. Citing medical news website STAT, a University of Chicago hospital participating in a study of the antiviral medication said it is seeing rapid recoveries in fever and respiratory symptoms, with nearly all patients discharged from the hospital …

These companies are racing to roll out COVID-19 treatments
4 years, 9 months ago

These companies are racing to roll out COVID-19 treatments

CNN  

New York CNN Business — Big Pharma companies and biotechs are racing to come up with an effective treatment for the Covid-19 novel coronavirus. Many other companies are also working on vaccines, including small biotechs Moderna, Novavax and Inovio as well as Big Pharma firm Pfizer, which is partnering with Germany’s BioNTech. But making and testing new vaccines may not …

Coronavirus drugs: Where we are and what we know
4 years, 9 months ago

Coronavirus drugs: Where we are and what we know

LA Times  

A health worker holds packets of chloroquine and hydroxychloroquine, two existing drugs that are being tested as treatments for COVID-19. Still, researchers hypothesized that chloroquine could help patients with the new disease by slowing the virus’ spread. About two dozen clinical trials are already underway in China to test chloroquine’s efficacy against the novel coronavirus. It’s a potentially less toxic …

What we know so far about drug therapy for novel coronavirus
4 years, 9 months ago

What we know so far about drug therapy for novel coronavirus

Firstpost  

Here is a list of drug treatments being experimented with right now, along with their effectiveness. The WHO, in a massive multi-country study dubbed ‘Solidarity’, will also test Kaletra - along with other drug combinations - for effectiveness. Chloroquine - the malaria drug A French study involving 25 COVID-19 patients looked at the effect of chloroquine in reducing viral load. …

No evidence ibuprofen worsens coronavirus: EU drugs watchdog
4 years, 9 months ago

No evidence ibuprofen worsens coronavirus: EU drugs watchdog

Al Jazeera  

European Medicines Agency said patients, doctors should consider anti-inflammatory drugs for COVID-19 treatment options. The European Union‘s healthcare regulator has said there currently is no evidence which links anti-inflammatory medicines such as ibuprofen with the worsening of COVID-19, the disease caused by the novel coronavirus. The European Medicines Agency said, on Wednesday, that it was monitoring the situation, adding that …

Coronavirus update: Decade-old medicine emerges as hope for COVID-19 victims
4 years, 10 months ago

Coronavirus update: Decade-old medicine emerges as hope for COVID-19 victims

Live Mint  

China has approved the use of Swiss drugmaker Roche's anti-inflammation drug Actemra for patients who develop severe complications from the coronavirus as it urgently hunts for new ways to combat the deadly infection that is spreading worldwide. China's National Health Commission said in treatment guidelines published online on Wednesday that Actemra can now be used to treat coronavirus patients with …

Coronavirus outbreak: Cocktail of flu, HIV drugs appears to help fight virus, say Thai doctors
4 years, 11 months ago

Coronavirus outbreak: Cocktail of flu, HIV drugs appears to help fight virus, say Thai doctors

India Today  

Thai doctors have seen success in treating severe cases of the new coronavirus with combination of medications for flu and HIV, with initial results showing vast improvement 48 hours after applying the treatment, they said on Sunday. The doctors from Rajavithi Hospital in Bangkok said a new approach in coronavirus treatment had improved the condition of several patients under their …

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