COVID-19 symptoms may be less severe in women than men, here’s why

Scientists have found a possible explanation for why men may have a greater risk than women for more severe symptoms and worse outcomes from COVID-19 regardless of age. Severity of COVID-19 may be less in women than men The researchers from the Wake Forest Baptist Medical Center in the US pointed to female sex hormone estrogen’s role in lowering the level of angiotensin-converting enzyme2 in the heart, which may modulate the severity of COVID-19 in women. “We know that coronavirus affects the heart and we know that estrogen is protective against cardiovascular disease in women, so the most likely explanation seemed to be hormonal differences between the sexes,” said the lead author of the review, Leanne Groban, a professor at Wake Forest School of Medicine. The review, they said, also pointed to estrogen’s lowering the level of ACE2 in the heart, which may modulate the severity of COVID-19 in women. “We hope that our review regarding the role of estrogenic hormones in ACE2 expression and regulation may explain the gender differences in COVID-19 infection and outcomes, and serve as a guide for current treatment and the development of new therapies,” Groban said.