Obesity, overweight can lead to diabetes: Study
Hindustan TimesOverweight and obese people have a higher chance of developing diabetes, but the exact mechanism is not well understood. "Between 30 million and 40 million people in the United States have Type 2 diabetes, and another 90 million to 100 million have risk factors that make them likely to develop Type 2 diabetes in the future," said senior investigator Clay F. Semenkovich, MD, director of the Division of Endocrinology, Metabolism & Lipid Research at the School of Medicine. Studying human tissue samples, Semenkovich, the Irene E. and Michael M. Karl Professor; first author Guifang Dong, PhD, a senior scientist; Xiaochao Wei, PhD, an associate professor of medicine; and other Washington University researchers found that the overproduction of insulin involves a process called palmitoylation. Examining tissue samples from people who were thin or overweight, and with and without diabetes, the researchers found that the people with diabetes were deficient in an enzyme that removes palmitate from beta cells. "We think that by increasing APT1 activity, we might reverse this process and potentially prevent people at risk from progressing to diabetes."
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Study finds how obesity triggers diabetes, may help prevent, delay disease
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