Scientists identify gene behind sectional vulnerability of brain to Alzheimer's
2 years, 4 months ago

Scientists identify gene behind sectional vulnerability of brain to Alzheimer's

Hindustan Times  

Scientists have uncovered why certain parts of the brain are particularly vulnerable to Alzheimer's damage. However, as senior author of the study Brian A. Gordon said there are some rare and atypical forms of Alzheimer's in which people first develop language or vision problems rather than memory problems. To understand why Alzheimer's brain damage occurs where it does, Gordon and colleagues studied 350 people who volunteered for memory and ageing studies through the School of Medicine's Charles F. and Joanne Knight Alzheimer's Disease Research Center. The researchers compared the patterns of protein clumps and tissue damage in the volunteers to the gene expression patterns of APOE and other genes associated with Alzheimer's disease as depicted in the Allen Human Brain Atlas, a detailed map of gene expression in the human brain compiled by the Allen Institute for Brain Sciences. In future works, Gordon and colleagues plan to explore how patterns of gene expression relate to patterns of tau damage in people with atypical Alzheimer's.

Disease Brain Gene Damage Areas Patterns Gordon Researchers Tau Krs Amyloid Tau Tangles  patterns  researchers  gene  disease  scientists  damage  areas  identify  sectional  alzheimers  amyloid  gordon  brain  tau  vulnerability

History of this topic

Should you get tested for an Alzheimer’s gene?
10 months, 3 weeks ago

Should you get tested for an Alzheimer’s gene?

Hindustan Times  

In a new paper in Nature Medicine, an international team of neurologists makes the compelling case that people with two copies of a gene called APOE4 aren’t just at risk of Alzheimer’s — they have a distinct form of the disease and are almost certain to develop its tell-tale brain plaques by age 65. Researchers have known for decades that …

People with two copies of a risk gene have genetic form of Alzheimer's, scientists say
10 months, 3 weeks ago

People with two copies of a risk gene have genetic form of Alzheimer's, scientists say

The Hindu  

People who carry two copies of the APOE4 gene are virtually guaranteed to develop Alzheimer's and face symptoms at an earlier age, researchers reported on Monday in a study that could redefine such carriers as having a new genetic form of the mind-wasting disease. ō"This study adds compelling data to suggest that people with two copies of this gene are …

One in 50 people is ‘highly likely’ to develop Alzheimer’s disease
10 months, 4 weeks ago

One in 50 people is ‘highly likely’ to develop Alzheimer’s disease

The Telegraph  

It could also help identify the best people to include in clinical trials for treatment. “But now we know that virtually all individuals with this duplicated gene develop Alzheimer’s biology.” The APOE gene comes in the variations APOE2, APOE3 and APOE4. “This research really suggests that we should be treating them quite early, at a younger age and at an …

Gene variant that increases Alzheimer's symptoms identified: Study
2 years, 3 months ago

Gene variant that increases Alzheimer's symptoms identified: Study

The Hindu  

Researchers have identified a gene variant which increases the risk of post-traumatic stress disorder and head injury associated with Alzheimer's disease and related dementias, according to a study. The study, led by Dr. Mark Logue, a statistician in the National Center for PTSD at the Veterans Affairs Boston Healthcare System, found an increase in risk due to PTSD and TBI …

Traumatic brain injury, PTSD associated with Alzheimer's: Research
2 years, 3 months ago

Traumatic brain injury, PTSD associated with Alzheimer's: Research

Hindustan Times  

The medical profession has never before investigated the effects of traumatic brain injury, post-traumatic stress disorder and genetic risk factors in a sizable cohort. Traumatic brain injury, PTSD associated with Alzheimer's: Research Researchers found that PTSD, TBI, and the e4 variant of the APOE gene exhibited high links with Alzheimer's disease and related dementias in a study of Veterans conducted …

Scientists identify gene behind sectional vulnerability of brain to Alzheimer’s
2 years, 4 months ago

Scientists identify gene behind sectional vulnerability of brain to Alzheimer’s

The Hindu  

Scientists have uncovered why certain parts of the brain are particularly vulnerable to Alzheimer's damage. However, as senior author of the study Brian A. Gordon said there are some rare and atypical forms of Alzheimer's in which people first develop language or vision problems rather than memory problems. To understand why Alzheimer's brain damage occurs where it does, Gordon and …

Experts Find a Link Between Alzheimer's Disease Risk Factor And Covid-19 Severity
4 years, 1 month ago

Experts Find a Link Between Alzheimer's Disease Risk Factor And Covid-19 Severity

News 18  

The gene that increases the risk of Alzheimer’s disease can increase a person’s susceptibility to and severity of Covid-19, researchers say. The study, published in journal ‘Cell Stem Cell’, suggests that the gene ApoE4 showed a higher susceptibility to SARS-CoV-2 infection. “Our study provides a causal link between the Alzheimer’s disease risk factor ApoE4 and Covid-19 and explains why some …

New clues on why women’s Alzheimer’s risk differs from men’s
5 years, 8 months ago

New clues on why women’s Alzheimer’s risk differs from men’s

Associated Press  

LOS ANGELES — New research gives some biological clues to why women may be more likely than men to develop Alzheimer’s disease and how this most common form of dementia varies by sex. At the Alzheimer’s Association International Conference in Los Angeles on Tuesday, scientists offered evidence that the disease may spread differently in the brains of women than in …

Alzheimer’s: New hope for drug, but it’s still early
6 years, 8 months ago

Alzheimer’s: New hope for drug, but it’s still early

CNN  

Story highlights Eighteen-month results for a new Alzheimer's drug show promise BAN2401 removed plaque and improved cognition better than a placebo Other drug trials have failed, so caution is needed, scientists say CNN — After a series of prominent failures, there’s reason to be hopeful in the search for a drug to slow the progression of Alzheimer’s disease. Results of …

HOW TO DETECT ALZHEIMER'S
6 years, 10 months ago

HOW TO DETECT ALZHEIMER'S

Daily Mail  

There is no known cure for Alzheimer's, but experts suggest physical exercise, social interaction and adding brain boosting omega-3 fats to your diet to prevent or slowdown the onset of symptoms. Common blood pressure pill could slow down Alzheimer's disease 'by boosting circulation to the brain's memory and learning centre by 20%' A study by Radboud University in the Netherlands …

Western diet as well as genetics up the risk of Alzheimer's Disease
7 years, 9 months ago

Western diet as well as genetics up the risk of Alzheimer's Disease

India TV News  

The western diet is laced in bad cholesterol, fats and sugar. This might influence the development of Alzheimer’s disease in people who religiously follow the western diet as well as those who carry a gene associated to the neurodegenerative disease. ApoE4 variant is responsible for increased inflammation, Alzheimer’s disease and cardiovascular disease whereas ApoE3 is not increasing the risk of …

Brain changes wrought by gene linked to Alzheimer’s may begin in childhood, scientists say
8 years, 8 months ago

Brain changes wrought by gene linked to Alzheimer’s may begin in childhood, scientists say

LA Times  

The gene that makes some people more vulnerable to Alzheimer’s disease as adults also affects the brain development and mental abilities of children, a new study shows. The researchers found a variety of differences in mental abilities and brain structure based on the age of the children and their particular version of the APOE gene. NEWSLETTER: Get the day’s top …

Researchers develop genetic test that can predict your risk of Alzheimer’s disease
8 years, 8 months ago

Researchers develop genetic test that can predict your risk of Alzheimer’s disease

LA Times  

New research into the genetic underpinnings of Alzheimer’s disease offers fresh evidence that the devastating brain disorder may gain a foothold years before dementia sets in, and takes a key step toward earlier detection of the disease. In a study that scoured the genes of healthy young people for the presence of variants linked to Alzheimer’s disease, researchers have found …

Gene Linked To Alzheimer's Poses A Special Threat To Women
10 years, 11 months ago

Gene Linked To Alzheimer's Poses A Special Threat To Women

NPR  

Gene Linked To Alzheimer's Poses A Special Threat To Women toggle caption iStockphoto A gene associated with Alzheimer's disease appears especially dangerous to women and may be one reason that more women than men are diagnosed with the disease. Sponsor Message "We believe that there is an increased risk for Alzheimer's in women, and it may be that APOE4 is …

Grappling With The Uncertainty Of Alzheimer's Testing
12 years, 7 months ago

Grappling With The Uncertainty Of Alzheimer's Testing

NPR  

Grappling With The Uncertainty Of Alzheimer's Testing Enlarge this image toggle caption Andrei Tchernov/iStockphoto.com Andrei Tchernov/iStockphoto.com Counselors have long cautioned about the downsides of genetic testing for Alzheimer's disease. But there's another reason some doctors and counselors have discouraged testing: Concern that if people learned that they were at higher risk for developing a serious, incurable neurological disease, it might …

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