
Reduction of fat in liver lowers risk of Non-Alcoholic Fatty Liver Disease: UoH study
The HinduHYDERABAD A study undertaken by research scholars at the School of Life Sciences, University of Hyderabad, showed that reduction of fat accumulation in the liver lowers the chances of one developing Non-Alcoholic Fatty Liver Disease, which is a serious health concern affecting 25% of the world’s population. Mitochondria, the cell’s powerhouse, empowers the liver to regulate lipid metabolism by enabling fatty acid oxidation during starvation and fatty acid synthesis during nutrient-rich conditions. The researchers claimed to have isolated two distinct sub-populations of mitochondria from the liver of a male Wistar rat—cytoplasmic mitochondria and lipid droplet-associated mitochondria—with the latter exhibiting higher fatty acid oxidation. Fatty acid oxidation capacity of ‘lipid droplet-associated mitochondria’, when isolated from a NAFLD rat model, was found to have fallen, thereby opening up new avenues for therapeutic intervention, said an official release.
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