
Exercise training may prevent the onset of Alzheimer's disease, says study
Hindustan TimesA recent study shows a memory biomarker, myokine Cathepsin B, increased in older adults following a 26-week structured aerobic exercise training. Exercise training may prevent the onset of Alzheimer's disease, says study The study, published in the journal Frontiers in Endocrinology, showed that the positive association between CTSB and cognition, and the substantial modulation of lipid metabolites implicated in dementia, support the beneficial effects of exercise training on brain function and brain health in asymptomatic individuals at risk for Alzheimer's. To address this issue, Henriette van Praag, PhD, from Florida Atlantic University's Schmidt College of Medicine and Brain Institute and Ozioma Okonkwo, PhD, Wisconsin Alzheimer's Disease Research Center and Department of Medicine at the University of Wisconsin-Madison and their collaborators, tested the hypotheses that three specific biomarkers, which are implicated in learning and memory, would increase in older adults following exercise training and correlate with cognition and metabolomics markers of brain health. "Our findings position CTSB, BDNF, and klotho as exercise biomarkers for evaluating the effect of lifestyle interventions on brain function," said van Praag, corresponding author, an associate professor of biomedical science, FAU's Schmidt College of Medicine, and a member of the FAU Brain Institute and the FAU Institute for Human Health & Disease Intervention. "The positive association between CTSB and cognition, and the substantial modulation of lipid metabolites implicated in dementia, support the beneficial effects of exercise training on brain function and brain health in asymptomatic individuals at risk for Alzheimer's disease," said van Praag.
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